Comparing median lethal concentration values using confidence interval overlap or ratio tests

Environmental Toxicology and Chemistry

Volumn 25, Issue 5, 2006, Pages 1441-1444

  Wheeler, Matthew W ^a   Park, Robert M ^a   Bailer, A John ^a,b  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b MIAMI UNIVERSITY   (United States)

Author keywords

Fieller's method; Median lethal concentration; Power; Significance testing; Type I error rates

Indexed keywords

MONTE CARLO METHODS; PROBABILITY; STATISTICAL TESTS; TOXICITY;

FIELLER'S METHOD; MEDIAN LETHAL CONCENTRATION; SIGNIFICANCE TESTING; TOXICOLOGY;

TOXIC MATERIALS;

FLUORANTHENE; FLUORENE DERIVATIVE;

MONTE CARLO ANALYSIS; SIMULATION; TOXICITY TEST; TOXICOLOGY;

ALGA; ARTICLE; COMPARATIVE STUDY; CONFIDENCE INTERVAL; LARVA; LC 50; MATHEMATICAL MODEL; MEDICAL RESEARCH; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; STATISTICAL ANALYSIS; ANIMAL; CYPRINIFORMES; DRUG EFFECT; LD 50; TOXICOLOGY;

ANIMALS; CONFIDENCE INTERVALS; CYPRINIDAE; FLUORENES; LARVA; LETHAL DOSE 50; TOXICOLOGY;

EID: 33749073225     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/05-320R.1     Document Type: Article

References (10)

1. Schenker N, Gentleman JF. 2001. On judging the significance of differences by examining by examining the overlap between confidence intervals. The American Statistician 55:182-186.
2. U.S. Environmental Protection Agency. 1999. Toxicity reduction evaluation guidance for municipal wastewater treatment plants. EPA 833B-99/002. Final Report. Office of Wastewater Management, Washington, DC.
3. Oris JT, Bailer AJ. 1997. Equivalence of concentration-response distributions in aquatic toxicology: Testing and implications for potency estimation. Environ Toxicol Chem 16:2204-2209.
4. Collett D. 2003. Modeling Binary Data, 2nd ed. CRC, Boca Raton, FL, USA.
5. Buonaccorsi J. 2002. Fieller's theorem. In El-Saarawi A, Piegorsch W, eds, Encyclopedia of Environmetrics, Vol 2. John Wiley, New York, NY, USA, pp 773-774.
6. Cox C. 2002. Delta method. In El-Saarawi A, Piegorsch W, eds, Encyclopedia of Environmetrics, Vol 1. John Wiley, New York, NY, USA, pp 488-489.
7. Payton ME, Greenstone MH, Schenker N. 2003. Overlapping confidence intervals or standard error intervals: What do they mean in terms of statistical significance? J Insect Sci 3:1-6.
8. Robertson JL, Preisler HK. 1992. Pesticide Bioassays with Arthropods. CRC, Boca Raton, FL, USA.
9. Thompson SK. 1992. Sampling. John Wiley, New York, NY, USA.
10. Venables WN, Smith DM. 2002. An Introduction to R. Network Theory, Bristol, UK.