Age-dependent loss of naïve T cells in TCR transgenic bone marrow chimeras

Immunobiology

Volumn 211, Issue 9, 2006, Pages 701-709

  Coleman, Clenton ^a   Howell, Koko ^a   Hobbs, Monte V ^a   Riggs, James E ^a  

^a RIDER UNIVERSITY   (United States)

Author keywords

Bone marrow; Chimera; Senescence; T cell; Transgenic

Indexed keywords

ANTIGEN; T LYMPHOCYTE RECEPTOR; VACCINE;

AGING; ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; BONE MARROW; CD4+ T LYMPHOCYTE; CHIMERA; CONTROLLED STUDY; DRUG RESPONSE; IMMUNITY; IN VIVO STUDY; LYMPH NODE; LYMPHOCYTE COUNT; LYMPHOCYTE DEPLETION; MEMORY T LYMPHOCYTE; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE; SPLEEN; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

EID: 33749068028     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2006.03.004     Document Type: Article

References (32)

1. Bosma M., and Carroll A. The SCID mouse mutant: definition, characterization, and potential uses. Ann. Rev. Immunol. 9 (1991) 323-350
2. Budd R., Cerottini J., Horvath C., Bron C., Pedrazzini T., Rowe R., and MacDonald H. Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation. J. Immunol. 138 (1987) 3120-3129
3. Dialynas D., Quan Z., Wall K., Pierres A., Quintans J., Loken M., Pierres M., and Fitch F. Characterization of the murine T cell surface molecule, designated L3T4, identified by the monoclonal antibody GK-1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J. Immunol. 131 (1983) 2445-2451
4. Dutton R., Bradley L., and Swain S. T cell memory. Ann. Rev. Immunol. 16 (1998) 201-223
5. Ernst D., Weigle W., McQuitty D., Rothermel A., and Hobbs M. Stimulation of murine T cell subsets with anti-CD3 antibody. Age-related defects in the expression of early activation molecules. J. Immunol. 142 (1989) 1413-1421
6. Ernst D., Hobbs M.V., Torbett B., Glasebrook A., Rehse M., Bottomly K., Hayakawa K., Hardy R., and Weigle W. Differences in the expression profiles of CD45RB, Pgp-1 and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice. J. Immunol. 145 (1990) 1295-1302
7. Finch C., and Kirkwood T. Chance, Development, and Aging (2000), Oxford University Press, NY p. 210
8. Gillis S., Kozak M., Durante M., and Weksler M. Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans. J. Clin. Invest. 67 (1981) 937-943
9. Hale T., Richardson B., Sweet L., McElligott D., Riggs J., Chu E., Glynn J., LaFrenz D., Ernst D., Rochford R., and Hobbs M. Age-related changes in mature CD4+ T cells: cell cycle analysis. Cell. Immunol. 220 (2003) 51-62
10. Haskins K., Kubo R., White J., Pigeon M., Kappler J., and Marrack J. The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody. J. Exp. Med. 157 (1983) 1149-1169
11. Haynes L., Linton P.-J., and Swain S. Age-related changes in CD4 T cells of T cell receptor transgenic mice. Mech. Age. Dev. 93 (1997) 95-105
12. Haynes L., Eaton S., Burns E., Randall T., and Swain S. CD4 T cell memory derived from young naïve cells functions well into old age, but memory generated from aged naïve cells functions poorly. Proc. Natl. Acad. Sci. USA 100 (2003) 15053-15058
13. Hirokawa K. The thymus and aging. In: Makinodan T., and Yunis E. (Eds). Immunology and Aging (1977), T. Plenum Medical Book Company, New York 51-72
14. Hobbs M., and Ernst D. The role of cytokines in aging. In: Aggarwal B., and Pui R. (Eds). Human Cytokines: Their Role in Disease and Therapy (1995), Blackwell Scientific Publications Inc., Cambridge, MA 353
15. Kearney E., Pape K., Loh D., and Jenkins M. Visualization of peptide-specific T cell immunity in vivo. Immunity 1 (1994) 327-339
16. Kimmig S., Przybylski G., Schmidt C., Laurisch K., Mowes B., Radbruch A., and Thiel A. Two subsets of naïve T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J. Exp. Med. 195 (2002) 789-794
17. Kohler S., Wagner U., Pierer M., Kimmig S., Oppmann B., Mowes B., Julke K., Romagnani C., and Thiel A. Post-thymic in vivo proliferation of naïve CD4+ T cells constrains the T cell repertoire in healthy human adults. Eur. J. Immunol. 35 (2005) 1987-1994
18. Lerner A., Yamada T., and Miller R. Pgp-1hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A. Eur. J. Immunol. 19 (1989) 977-982
19. Li S., Cai Z., Shi W., Brunmark A., Jackson M., and Linton P. Early antigen-specific response by naïve CD8 T cells is not altered with aging. J. Immunol. 168 (2002) 6120-6127
20. Linton P.-J., Haynes L., Klinman N., and Swain S. Antigen-independent changes in naïve CD4 T cells with aging. J. Exp. Med. 184 (1996) 1891-1900
21. Linton P.-J., Li S., Zhang Y., Bautista B., Huynh Q., and Trinh T. Intrinsic versus environmental influences on T-cell responses in aging. Immunol. Rev. 205 (2005) 207-219
22. Mackall C., Punt J., Morgan P., Farr A., and Gress R. Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution. Eur. J. Immunol. 28 (1998) 1886-1893
23. Makinodan T., and Kay M. Age influence on the immune system. Adv. Immunol. 29 (1980) 287-330
24. Messaoudi I., Warner J., Nikolich-Zugich D., Fischer M., and Nikolich-Zugich J. Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo. J. Immunol. 176 (2006) 301-308
25. Mittler J., and Lee W.T. Antigen-specific CD4 T cell clonal expansion and differentiation in the aged lymphoid microenvironment. I. The primary T cell response is unaffected. Mech. Age. Dev. 125 (2004) 47-57
26. Murali-Krishna K., and Ahmed R. Cutting edge: naïve T cells masquerading as memory cells. J. Immunol. 165 (2000) 1733-1737
27. Murphy K., Heimberger A., and Loh D. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250 (1990) 1720-1723
28. Nagelkerken L., Hertogh-Huijbregts A., Dobber R., and Drager A. Age-related changes in lymphokine production related to a decreased number of CD45RBhi CD4+ T cells. Eur. J. Immunol. 21 (1991) 273-278
29. Naylor K., Li G., Vallejo A., Lee W.-W., Koetz K., Bryl E., Witkowski J., Fulbright J., Weyand C., and Goronzy J. The influence of age on T cell generation and TCR diversity. J. Immunol. 174 (2005) 7446-7452
30. Pape K., Kearney E., Khoruts A., Mondino A., Merica R., Chen Z., Ingulli E., White J., Johnson J., and Jenkins M. Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cells for the study of T-cell activation in vivo. Immunol. Rev. 156 (1997) 67-78
31. Riggs J., Hobbs M., and Mosier D. CD4+CD8- thymocytes from neonatal mice induce IgM production in SCID mice. J. Immunol. 148 (1992) 1389-1395
32. Timm J., and Thoman M. Maturation of CD4+ lymphocytes in the aged microenvironment results in a memory-enriched population. J. Immunol. 162 (1999) 711-717