Nitrate administration increases blood flow in dysfunctional but viable myocardium, leading to improved assessment of myocardial viability: A PET study

Journal of Nuclear Medicine

Volumn 47, Issue 8, 2006, Pages 1307-1311

  Slart, Riemer H J A ^a   Agool, Ali ^a   Van Veldhuisen, Dirk J ^a   Dierckx, Rudi A ^a   Bax, Jeroen J ^b  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Left ventricular dysfunction; Nitroglycerin; Positron emission tomography; Viability

Indexed keywords

AMMONIA N 13; FLUORODEOXYGLUCOSE F 18; NITRATE; TETROFOSMIN TC 99M; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT; TECHNETIUM; VASODILATOR AGENT;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; CHRONIC DISEASE; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DRUG EFFICACY; GOLD STANDARD; HEART FUNCTION; HEART LEFT VENTRICLE FAILURE; HUMAN; MALE; OUTCOME ASSESSMENT; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STATISTICAL ANALYSIS; TREATMENT RESPONSE; AGED; BLOOD FLOW VELOCITY; CHEMISTRY; CLINICAL TRIAL; FEMALE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; METHODOLOGY; MIDDLE AGED; PATHOLOGY; PERFUSION;

AGED; BLOOD FLOW VELOCITY; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; MALE; MIDDLE AGED; MYOCARDIUM; NITRATES; PERFUSION; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TECHNETIUM; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; VASODILATOR AGENTS; VENTRICULAR DYSFUNCTION, LEFT;

EID: 33749044393     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Rahimtoola SH. The hibernating myocardium. Am Heart J. 1989;117:211-221.
2. Travin MI, Bergmann SR. Assessment of myocardial viability. Semin Nucl Med. 2005;35:2-16.
3. Slart RH, Bax JJ, De Boer J, et al. Comparison of (99m)Tc-sestamibi/(18) FDG DISA SPECT with PET for the detection of viability in patients with coronary artery disease and left ventricular dysfunction. Eur J Nucl Med Mol Imaging. 2005;32:972-979.
4. Flotats A, Carrio I, Estorch M, et al. Nitrate administration to enhance the detection of myocardial viability by technetium-99m tetrofosmin single-photon emission tomography. Eur J Nucl Med. 1997;24:767-773.
5. Brown BG, Bolson E, Petersen RB, Pierce CD, Dodge HT. The mechanisms of nitroglycerin action: stenosis vasodilatation as a major component of the drug response. Circulation. 1981;64:1089-1097.
6. Cohn PF, Maddox D, Holman BL, et al. Effect of sublingually administered nitroglycerin on regional myocardial blood-flow in patients with coronary-artery disease. Am J Cardiol. 1977;39:672-678.
7. Ficaro EP, Kritzman JN, Corbett JR. Development and clinical validation of normal Tc-99m sestamibi database: comparison of 3D-MSPECT to Cequal [abstract]. J Nucl Med. 1999;40(suppl):125P.
8. Knuuti MJ, Yki-Jarvinen H, Voipio-Pulkki LM, et al. Enhancement of myocardial [fluorine-18]fluorodeoxyglucose uptake by a nicotinic acid derivative. J Nucl Med. 1994;35:989-998.
9. 18F-FDG SPECT using acipimox for the assessment of myocardial viability. J Nucl Med. 2003;44:877-883.
10. 18F]fluorodeoxyglucose in patients with chronic coronary artery disease: a functional and morphological approach to the detection of residual myocardial viability. Circulation. 1995;91:1006-1015.
11. Hutchins GD, Schwaiger M, Rosenspire KC, et al. Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging. J Am Coll Cardiol. 1990;15:1032-1042.
12. Mehmel HC, Katus H, Bassemir KR, et al. Comparison between the effect of post-extrasystolic potentiation and the effect of nitrates on left-ventricular function for the differentiation between reversible and irreversible left-ventricular asynergy. Basic Res Cardiol. 1980;75:390-399.
13. Helfant RH, Pine R, Meister SG, et al. Nitroglycerin to unmask reversible asynergy: correlation with post coronary-bypass ventriculography. Circulation. 1974;50:108-113.
14. Bodenheimer MM, Banka VS, Hermann GA, et al. Reversible asynergy: histopathologic and electrographic correlations in patients with coronary-artery disease. Circulation. 1976;53:792-796.
15. Sciagra R, Bisi G, Santoro GM, et al. Influence of the assessment of defect severity and intravenous nitrate administration during tracer injection on the detection of viable hibernating myocardium with data-based quantitative technetium 99m-labeled sestamibi single-photon emission computed tomography. J Nucl Cardiol. 1996;3:221-230.
16. Sciagra R, Bisi G, Santoro GM, et al. Comparison of baseline-nitrate technetium-99m sestamibi with rest-redistribution thallium-201 tomography in detecting viable hibernating myocardium and predicting postrevascularization recovery. J Am Coll Cardiol. 1997;30:384-391.
17. Sciagra R, Pellegri M, Pupi A, et al. Prognostic implications of Tc-99m sestamibi viability imaging and subsequent therapeutic strategy in patients with chronic coronary artery disease and left ventricular dysfunction. J Am Coll Cardiol. 2000;36:739-745.
18. Sciagra R, Leoncini M, Marcucci G, Dabizzi RP, Pupi A. Technetium-99m sestamibi imaging to predict left ventricular ejection fraction outcome after revascularisation in patients with chronic coronary artery disease and left ventricular dysfunction: comparison between baseline and nitrate-enhanced imaging. Eur J Nucl Med. 2001;28:680-687.
19. Bisi G, Sciagra R, Santoro GM, Fazzini PF. Rest technetium-99m sestamibi tomography in combination with short-term administration of nitrates: feasibility and reliability for prediction of postrevascularization outcome of asynergic territories. J Am Coll Cardiol. 1994;24:1282-1289.
20. Bax JJ, Poldermans D, Elhendy A, Boersma E, Rahimtoola SH. Sensitivity, specificity, and predictive accuracies of various noninvasive techniques for detecting hibernating myocardium. Curr Probl Cardiol. 2001;26:141-186.
21. Fallen EL, Nahmias C, Scheffel A, et al. Redistribution of myocardial blood-flow with topical nitroglycerin in patients with coronary-artery disease. Circulation. 1995;91:1381-1388.
22. Tadamura E, Mamede M, Kubo S, et al. The effect of nitroglycerin on myocardial blood flow in various segments characterized by rest-redistribution thallium SPECT. J Nucl Med. 2003;44:745-751.