Drug Solubilization with Organic Solvents, Surfactants and Lipids

The Practice of Medicinal Chemistry: Second Edition

Volumn , Issue , 2003, Pages 631-648

  Stahl, P Heinrich ^a  

^a Cosmas Consult ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DISPERSIONS; DRUG DOSAGE; PHOSPHOLIPIDS; PROBLEM SOLVING; SOLUBILITY; SOLUTIONS; SURFACE ACTIVE AGENTS;

AMPHIPHILIC SURFACTANTS; COMPLETE DISSOLUTION; DRUG SOLUBILIZATION; FORMULATION DEVELOPMENT; HETEROGENEOUS DISPERSION; OPTIMIZING PROGRAMS; SPECIALIZED SYSTEMS; TECHNOLOGICAL SYSTEM;

DRUG DELIVERY;

EID: 33749030876     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012744481-9/50041-6     Document Type: Chapter

References (36)

1. Amidon G.L., Lennernäs H., Shah V.P., Crison J.R. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 1995, 12:413-420.
2. U.S.Department of Health and Human Services, F.D.A., Center for Drug Evaluation and Research (CDER) Guidance for Industry. Waiver of In Vivo Bioavailability and Bioequivalence Studies for Immediate-Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System 2000, August 31, Office of Training and Communications, Division of Communications Management, Drug Information Branch, Châtenay-Malabry.
3. Nema S., Washkuhn R., Brendel R. Excipients and their use in injectable products. PDA J. Pharm. Sci. Technol. 1997, 51:161-171.
4. Yalkowsky S.H., Roseman T.J. Solubilization of drugs by co-solvents. Techniques of Solubilization of Drugs 1981, 91-134. Marcel Dekker, HFD-210, 5600 Fishers Lane, Rockville, MD. S.H. Yalkowsky (Ed.).
5. Yalkowsky S.H., Flynn G., Amidon G.L. Solubility of nonelectrolytes in polar solvents. J. Pharm. Sci. 1972, 61:983-984.
6. Yalkowsky S.H., Valvani S.C., Amidon G.L. Solubility of nonelectrolytes in polar solvents IV: Nonpolar drugs in mixed solvents. J. Pharm. Sci. 1976, 65:1488-1494.
7. Valvani S.C., Yalkowsky S.H., Roseman T.J. Solubility and partitioning IV: Aqueous solubility and octanol-water partition coefficients of liquid nonelectrolytes. J. Pharm. Sci. 1981, 70:502-507.
8. Gould P.L., Goodman M., Hanson P.A. Investigation of the solubility relationships of polar, semi-polar and non-polar drugs in mixed co-solvent systems. Int. J. Pharm. 1984, 19:149-159.
9. Kramer S.F., Flynn G.L. Solubility of organic hydrochlorides. J. Pharm. Sci. 1972, 61:1896-1904.
10. Yalkowsky S.H., Valvani S.C. Precipitation of solubilized drugs due to injection or dilution. Drug Intell. Clin. Pharm. 1977, 11:417-419.
11. Aboutaleb A.E., Abdelzaher A. A study on the solubilization of chloramphenicol. Pharmazie 1981, 36:102-106.
12. Griffin W.C. J. Soc. Cosmet. Chem. 1949, 1:311.
13. Monteil A., Navarrot P., Kienlen J., DuCailar J. 2 cases of anaphylactic-type reaction to alphadione (Alfatesine, Althesin, CT 13.41). Ann. Anesthesiol. Fr. 1976, 17:71-76.
14. Volcheck G.W., Van Dellen R.G. Anaphylaxis to intravenous cyclosporine and tolerance to oral cyclosporine: case report and review. Ann. Allergy Asthma Immunol. 1998, 80:159-163.
15. Ebo D., Piel G.C., Conraads V., Stevens W.J. IgE-mediated anaphylaxis after first intravenous infusion of cyclosporin. Ann. Allergy Asthma Immunol. 2001, 87:243-245.
16. Jain N., Yang G., Yalkowsky S.H. Solubilization of NSC-639829 by combined effects of pH with cosolvents, surfactants, and complexants. Int. J. Pharm. 2001, 225:41-47.
17. Thoma K., Albert K. Amphiphilic drugs. 2. Relation between colloidal properties and pharmaceutic-technological, pharmacokinetic and pharmacodynamic behavior. Pharmazie 1983, 38:807-817.
18. Hussain M.A., Wu L.S., Koval C., Hurwitz A.R. Parenteral formulation of the kappa agonist analgesic, DuP 747, via micellar solubilization. Pharm. Res. 1992, 9:750-752.
19. Tarr B.D., Sambandan T.G., Yalkowsky S.H. A new parenteral emulsion for the administration of taxol. Pharm. Res. 1987, 4:162-165.
20. Charman W.N. Lipid vehicle and formulation effects on intestinal lymphatic drug transport. Lymphatic Transport of Drugs 1992, 113-179. CRC Press, New York. W.N. Charman, V.L. Stella (Eds.).
21. Charman W.N. Lipids, lipophilic drugs, and oral drug delivery - Some emerging concepts (Mini-Review). J. Pharm. Sci. 2000, 89:967-978.
22. Charman W.N. Lipids, lymph and lipidic formulations. Bull. Tech. Gattefossé 1997, 90:27-33.
23. Ziegenmeyer J., Führer C. Mikroemulsionen als topische Arzneiform. Acta Pharm. Tech. 1980, 26:273-275.
24. Drewe J., Meier R., Vonderscher J.D., et al. Enhancement of the oral absorption of cyclosporin in man. Br. J. Clin. Pharm. 1992, 34:60-64.
25. Gershanik T., Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur. J. Pharm. Biopharm. 2000, 50:179-188.
26. Isele U., Van Hoogevest P., Hilfiker R., et al. Large-scale production of liposomes containing monomeric zinc phthalocyanine by controlled dilution of organic solvents. J. Pharm. Sci. 1994, 83:1608-1616.
27. Isele U., Schieweck K., Kessler R., et al. Pharmacokinetics and body distribution of liposomal zinc phthalocyanine in tumorbearing mice: influence of aggregation state, particle size, and composition. J. Pharm. Sci. 1995, 84:166-173.
28. Papahadjopoulos D., Vail W.J., Jacobson K., Poste G. Cochleate lipid cylinders: formation by fusion of unilamellar lipid vesicles. Biochim. Biophys. Acta 1975, 394:483-491.
29. Zarif L., Graybill J., Perlin D., Mannino R. Cochleates: New lipid-based drug delivery system. J. Liposome Res. 2000, 10:523-538.
30. Zarif L. Elongated supramolecular assemblies in drug delivery. Review. J. Control Rel. 2002, 80:7-23.
31. Santangelo R., Paderu P., Delmas G., et al. Efficacy of oral cochleate-amphotericin B in a mouse model of systemic candidiasis. Antimicrob. Agents Chemother. 2000, 44:2356-2360.
32. Leigh M., van Hoogevest P., Tiemessen H. Optimising the oral bioavailability of the poorly water-soluble drug cyclosporin A using membrane lipid technology. Drug Del. Syst. Sci. 2001, 1:73-77.
33. Illig K., Mueller R.L., Ostrander K.D., Swanson J.R. Use of Microfluidizer® processing for preparation of pharmaceutical suspensions. Pharm. Technol. 1996, 78.
34. Gassmann P., List M., Schweitzer A., Sucker H. Hydrosols - alternatives for the parenteral application of poorly water soluble drugs. Eur. J. Pharm. Biopharm. 1994, 40:64-72.
35. Goldberg A.H., Gibaldi M., Kanig J.L. Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures III. Experimental evaluation of griseofulvin-succinic acid solid solution. J. Pharm. Sci. 1966, 55:487-492.
36. Alvarez-Nunez F.A., Pinsuwan S., Lerkpulsawad S., Yalkowsky S.H. Effect of the most common co-solvents upon the extent of solubilization of some drugs: log-linear model. AAPS Annual Meeting, San Francisco, CA, USA 1998, Volume 1. 4, Poster 2433.