13C breath tests: Transition from research to clinical practice

Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring

Volumn , Issue , 2005, Pages 457-478

  Modak, A S ^a  

^a CAMBRIDGE ISOTOPE LABORATORIES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33749025894     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1142/9789812701954_0033     Document Type: Chapter

References (114)

1. Lacroix M, Mosora F, Pontus M, Lefebvre P, Luyckz A, Lopez-Habib G. Glucose naturally labeled with carbon-13: use for metabolic studies in man. Science 1973; 181: 445-446.
2. 13C-urea breath test. Lancet 1987; 329: 1174-1177.
3. Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993; 6: 1368-1370.
4. Phillips M, Boehmer JP, Cataneo RN, Cheema T, Eisen HJ, Fallon JT, Fisher PE, Gass A, Greenberg J, Kobashigawa J, Mancini D, Rayburn B, Zucker MJ. Heart allograft rejection: detection with breath alkanes in low levels (the HARDBALL study). J Heart Lung Transplant 2004; 23: 701-708.
5. Nau H, Rating D, Koch S, Hauser I, Helge H, Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother’s milk and clinical status in neonates of epileptic mothers. J Pharmacol Exp Ther 1981; 219: 768-777.
6. 13C-urea breath test. Lancet 1995; 345: 961-962.
7. 13C -urea breath test. Nippon Shokakibyo Gakkai Zasshi 2001; 98: 853.
8. 12C for carbon dioxide in human breath. Anal Chem 2002; 74: 2003-2007.
9. 13C-xylose breath test for the diagnosis of small bowel bacterial overgrowth in children. J Pediatr Gastroenterol Nutr 1997; 25: 153-158.
10. 13C-sorbitol breath test in diagnosis of small bowel bacterial overgrowth. Gastroenterology 1998; 114: A417.
11. 13C-labeled glycocholate breath test to diagnosis of bacterial overgrowth and ileal dysfunction. J Lab Clin Med 1977; 90: 431-439.
12. Ghoos Y, Geypens B. Gastric emptying test-kit and method of testing gastric emptying of solid meal. PCN 2001-10-04 2001072342/WO-A1.
13. 13C-labelled test meal. PCN 2004-05-06 2004037298/WO-A1.
14. 13C-octanoic acid breath test: a preliminary study. J Gastroenterol 2003; 38: 298-299.
15. 13C-octanoic acid breath test in measuring human solid gastric emptying. J Gastroenterol Hepatol 2003; 18: 41-46.
16. 13C-octanoic acid breath test for assessment of solid-phase gastric emptying in dogs. Am J Vet Res 2001; 62: 1939-1944.
17. 13C-acetate breath test accurately reflects gastric emp-tying of liquids in both liquid and semisolid test meals. Gastroenterology 1995; 108: 1048-1055.
18. 13C-acetate breath test. Gerontology 2002; 48: 381-386.
19. 13C-acetate breath test and Tc-99m gastric emptying scintigraphy in children with impaired gastrointestinal motility. Journal of Nuclear Medicine 2004; 44: 348P-349P.
20. 13C-acetate breath test: a validation study. Dig Liver Dis 2004; 36: 260-264.
21. 13C-octanoic acid breath test. Am J Gastroenterol 2000; 95: 2751-2761.
22. Folwaczny C, Wawarta R, Otto B, Friedrich S, Landgraf R, Riepl RL. Gastric emptying of solid and liquid meals in healthy controls compared with long-term type-1 diabetes mellitus under optimal glucose control. Exp Clin Endocrinol Diabetes 2003; 111: 223-229.
23. 13C-octanoic acid breath test versus scintigraphy in diabetics. Z Gastroenterol 2003; 41: 383-390.
24. 13C-octanoic acid breath test in patients with functional dyspepsia: comparison with ultrasonography. Scand J Gastroenterol 2002; 37: 662-666.
25. Van Vlem B, Schoonjans R, Vanholder R, Vandamme W, De Vos M, Lameire N. Dyspepsia and gastric emptying in chronic renal failure patients. Clin Nephrol 2001; 56: 302-307.
26. Symonds EL, Omari TI, Webster JM, Davidson GP, Butle RN. Relation between pancreatic lipase activity and gastric emptying rate in children with cystic fibrosis. J Pediatr 2003; 143: 772-775.
27. 13C-phenylalanine breath test. Chem Pharm Bull (Tokyo) 1998; 46: 1330-1332.
28. 13C]-phenylalanine breath test for the assessment of liver function. Isotopes Environ Health Stud 1999; 35: 147-156.
29. 13C-phenylalanine breath test. Eur J Clin Invest 2001; 31: 356-361.
30. 13C-breath tests in hepatology (cytosolic liver function). Eur Rev Med Pharmacol Sci 2004; 8: 47-49.
31. Wagner D, Baker M, Burke P, Forse R, Palombo J, Bistrian B. Liver function breath test using aromatic amino acids. PCN 1994-12-22 1994028941/WO-Al.
32. Bastien MC, Leblond F, Pichette V, Villeneuve JP. Differential alteration of cytochrome P450 isoenzymes in two experimental models of cirrhosis. Can J Physiol Pharmacol 2000; 78: 912-919.
33. 13C -aminopyrine oral load. Comparison with MEGX test in functional differentiation between chronic hepatitis and liver cirrhosis. Hepatogastroen-terology 2000; 47: 234-238.
34. Schmidt LE, Olsen AK, Stentoft K, Rasmussen A, Kirkegaard P, Dalhoff K. Early postoperative erythromycin breath test correlates with hepatic cytochrome P4503A activity in liver transplant recipients. Clin Pharmacol Ther 2001; 70: 446-454.
35. Dowling TC, Briglia AE, Fink JC, Hanes DS, Light PD, Stackiewicz L, Karyekar CS, Eddington ND, Weir MR, Henrich WL. Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease. Clin Pharmacol Ther 2003; 73: 427-434.
36. Salvat C, Mouly S, Rizzo-Padoin N, Knellwolf AL, Simoneau G, Duet M, Nataf V, Bailliart O, Bergmann JF. The [UC-N-methyl]-erythromycin breath test dosimetry complies with the French regulations for radiation safety. Fundam Clin Pharmacol 2003; 17: 349-353.
37. 14C]-erythromycin breath and urine test. Am J Physiol Gastrointest Liver Physiol 2003; 285: G470-482.
38. 13C-caffeine breath test as a noninvasive, quantitative test of liver function. Hepatology 2003; 38: 1227-1236.
39. Webster E, Mclntyre J, Choonara I, Preston T. The Caffeine Breath Test and CYP1A2 Activity in Children. Paediatric and Perinatal Drug Therapy 2002; 5: 28-33.
40. 13C-methacetin breath test for quantitative noninvasive liver function analysis with an isotope-specific nondispersive infrared spectrometer in liver cirrhosis. Dtsch Med Wochenschr 1998; 123: 1467-1471.
41. 13C-methacetin breath test. Aliment Pharmacol Ther 2003; 17: 271-277.
42. 13C-methionine breath test. Scand J Gastroenterol 2000; 35: 650-653.
43. 13 C-methionine breath test in patients with macrovesicular steatosis and patients with cirrhosis. Med Sci Monit 2003; 9: CR6-11.
44. Mion F, Rousseau M, Brazier JL, Minaire Y. Human hepatic macrovesicular steatosis: a noninvasive study of mitochondrial ketoisocaproic acid decarboxylation. Metabolism 1995; 44: 699-700.
45. Gabe S, Williams R, Silk D. The ketoisocaproic acid breath test is a dynamic in vivo test of mitochondrial energy production. Gastroenterology 1997; 112: A1268.
46. 13C-ketoisocaproic breath test for liver mithocondrial function. Journal of Hematology 2001; 34: 198.
47. 13C breath test for measurement of liver function. Gut 1998; 43 Suppl 3: S25-27.
48. 13C] breath test of galactose and fructose for quantitative liver function. J Surg Res 2001; 96: 90-95.
49. 13C]-methionine breath test. J Surg Res 2001; 95: 195-199.
50. 13C]-phenylalanine breath test. Surgery 2002; 132: 849-856.
51. Di Campli C, Angelini G, Armuzzi A, Nardo B, Zocco MA, Candelli M, Santoliquido A, Cavallari A, Bernardi M, Gasbarrini A. Quantitative evaluation of liver function by the methionine and aminopyrine breath tests in the early stages of liver transplantation. Eur J Gastroenterol Hepatol 2003; 15: 727-732.
52. 13C-methacetin breath test for monitoring hepatic function in cirrhotic patients before and after liver transplantation. Aliment Pharmacol Ther 2003; 18: 785-790.
53. 13C-methacetin breath test for monitoring hepatic function in cirrhotic patients before and after liver transplantation. Aliment Pharmacol Ther 2004; 19: 243.
54. 13C-phenylalanine breath test. Gastroenterology 2000; 118: AGA A559.
55. Freeman R, Dixon M, Horth B, Palladino M, Melanson A, Cooper J, Rohrer R, Modak A. Hepatic oxidation of orally delivered amino acids remains impaired for weeks after living liver donation. Am J Transplantation 2004; 4 (Suppl 8): P1051.
56. 13C-aminopyrine breath tests for the assessment of hepatic disease severity. Journal of Hematology 1999; 30: 263.
57. 13C-methacetin breath tests for the evaluation of functional liver capacity and disease severity in chronic liver diseases. Journal of Hepatology 1999; 30: 274.
58. 13C-breath test for quantitative assessment of liver function in humans. Hepatogastroenterology 1995; 42: 931-938.
59. 13C-methacetin breath test for quantitative liver function testing. Z Gastroenterol 1997; 35: 609-614.
60. 13C]-phenylalanine breath test reflects histological changes in the liver. J Surg Res 2003; 114: 120-125.
61. 13C]-galactose breath test: correlation with liver fibrosis in chronic hepatitis C. Eur J Clin Invest 1999; 29: 624-629.
62. 13C-methacetin breath test to evaluate functional capacity of hepatocyte in chronic liver disease. Dig Liver Dis 2000; 32: 226-232.
63. Tugtekin I, Wachter U, Barth E, Weidenbach H, Wagner DA, Adler G, Georgieff M, Radermacher P, Vogt JA. Phenylalanine kinetics in healthy volunteers and liver cirrhotics: implications for the phenylalanine breath test. Am J Physiol Endocrinol Metab 2002; 283: E1223-1231.
64. 13C]-phenylalanine breath test. J Gastroenterol 2003; 38: 1086-1090.
65. Schmidt LE, Rasmussen A, Kirkegaard P, Dalhoff K. Relationship between postoperative erythromycin breath test and early morbidity in liver transplant recipients. Transplantation 2003; 76: 358-363.
66. Okano Y, Hase Y, Kawajiri M, Nishi Y, Inui K, Sakai N, Tanaka Y, Takatori K, Kajiwara M, Yamano T. In vivo studies of phenylalanine hydroxylase by phenylalanine breath test: diagnosis of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency. Pediatr Res 2004; 56: 714-719.
67. Thompson GN, Bresson JL, Pacy PJ, Bonnefont JP, Walter JH, Leonard JV, Saudubray JM, Halliday D. Protein and leucine metabolism in maple syrup urine disease. Am J Physiol 1990; 258: E654-660.
68. 13C-propionate in vivo in patients with disorders of propionate metabolism. Pediatr Res 1991; 30: 15-22.
69. 2 breath test curve. Biochem Soc Trans 1998; 26: S184.
70. 13C]-ureide. Rapid Commun Mass Spectrom 1999; 13: 1252-1256.
71. 13C]-ureide requires further validation. J Pediatr Gastroenterol Nutr 2002; 34: 570-571; author reply 571.
72. 13C]-ureides. Eur J Clin Nutr 2003; 57: 1017-1024.
73. Coremans G, Geypens B, Vos R, Tack J, Margaritis V, Ghoos Y, Janssens J. Influence of continuous isobaric rectal distension on gastric emptying and small bowel transit in young healthy women. Neurogastroenterol Motil 2004; 16: 107-111.
74. 13C-labeled trioctanoin breath test for exocrine pancreatic function test in patients after pancreatoduodenectomy. Am J Gastroenterol 1993; 88: 64-69.
75. 13C-Hiolein breath test. Gut 1996; 39: 668-674.
76. 13C-Hiolein breath test: evidence for normalized fat assimilation with high dose pancreatin therapy. Z Gastroenterol 1997; 35: 123-129.
77. 13Carbon mixed triglyceride breath test and pancreatic enzyme supplementation in cystic fibrosis. Arch Dis Child 1997; 76: 349-351.
78. 13C-Triolein breath test to assess the effect of pancreatic enzyme on intraluminal lipolysis during continues enteral feeds in cystic fibrosis. Journal of Pediatric Gastroenterology and Nutrition 1999; 28: 594.
79. 13C-breath tests in pancreatic exocrine insufficiency: A comparative study. Gastroenterology 2000; 118: AGA A424.
80. 13C-mixed triglyceride breath test: A noninvasive method to assess lipase activity in children. Journal of Pediatric Gastroenterology and Nutrition 2001; 32: 579-585.
81. 13C-mixed triglyceride breath test as an indirect pancreatic function test. Scand J Gastroenterol 1998; 33 (3): 327-334.
82. 13C-Hiolein breath test in assessing pancreatic exocrine insufficiency. Hepatobiliary Pancreat Dis Int 2003; 2: 449-452.
83. 13C-labeled lipids: trioctanoin, triolein, and palmitic acid breath tests. Gastroenterology 1982; 82: 911-917.
84. McClean P, Harding M, Coward WA, Green MR, Weaver LT. Measurement of fat digestion in early life using a stable isotope breath test. Arch Dis Child 1993; 69: 366-370.
85. Bamba T, Chikamochi N, Fuse K, Fujiyama Y, Nakajo S, Hosoda S, Watanabe H, Morikawa J. The clinical usefulness of carbon-13 triolein breath test for the evaluation of malabsorption syndrome. Radioisotopes 1993; 42: 409-412.
86. De Boeck K, Delbeke I, Eggermont E, Veereman-Wauters G, Ghoos Y. Lipid digestion in cystic fibrosis: comparison of conventional and high-lipase enzyme therapy using the mixed-triglyceride breath test. J Pediatr Gastroenterol Nutr 1998; 26: 408-411.
87. 13C-labelled trioctanoin breath test. J Trop Pediatr 1999; 45: 87-94.
88. Janghorbani M, Schuette S, Cohen M. Method for measuring fat digestion and absorption formulation to aid in measuring fat absorption. PAT 1999-12-28 06006754.
89. 13C-triolein breath test for fat malabsorption in adult patients with cystic fibrosis. J Gastroenterol Hepatol 2004; 19: 448-453.
90. 13C-leucine and energy expenditure in preterm infants. Pediatr Res 1990; 28: 147-152.
91. 13CC>2-breath tests in nutritional diagnosis: present applications and future possibilities. In: Dietze GJ, Grunert A, Kleinberger G, Wolfram G, eds. Clinical Nutrition and Metabolic Research, Basel: Karger, 1985: 192-207.
92. Garlick P, McNurlan A, Essen P, Wernerman J. Measurement of tissue protein synthesis rates in vivo: a critical analysis of contrasting methods. Am J Physiol 1994; 266: E287-297.
93. Lu Z, Zhang R, Diasio RB. Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy. Cancer Res 1993; 53: 5433-5438.
94. Lu Z, Zhang R, Carpenter JT, Diasio RB. Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer: implication for 5-fluorouracil-based chemotherapy. Clin Cancer Res 1998; 4: 325-329.
95. Etienne MC, Lagrange JL, Dassonville O, Fleming R, Thyss A, Renee N, Schneider M, Demard F, Milano G. Population study of dihydropyrimidine dehydrogenase in cancer patients. J Clin Oncol 1994; 12: 2248-2253.
96. 13C-uracil breath test. Clin Cancer Res 2004; 10: 2652-2658.
97. Ezzeldin H, Diasio R. Dihydropyrimidine dehydrogenase deficiency, a phar-macogenetic syndrome associated with potentially life-threatening toxicity following 5-fluorouracil administration. Clin Colorectal Cancer 2004; 4: 181-189.
98. 13C]-dihydrouracil (DHU) plasma levels. Journal of Clinical Oncology 2004; 22 (14S): 2130.
99. 13C-bicarbonate breath test as a measure of gastric emptying. Am J Gastroenterol 1991; 86: 821-823.
100. 2 in parenterally fed infants. Eur J Clin Nutr 1990; 44: 3-9.
101. 2 breath test. Med Sci Sports Exerc 2001; 33: 834-838.
102. 13C]-bicarbonate tracer technique to measure neonatal energy expenditure. Pediatr Res 2000; 47: 787-791.
103. 2 breath test. Med SciSports Exerc 1997; 29: 1263-1268.
104. 2. Eur Respiratory J 2004; 24 (Suppl 48): P2081.
105. Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. Jama 1998; 279: 1200-1205.
106. Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W. Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review. Jama 2001; 286: 2270-2279.
107. 13C breath test in gastroenterological practice. Scand J Gastroenterol Suppl 1998; 225: 13-18.
108. de Meer K, Roef MJ, Kulik W, Jakobs C. In vivo research with stable isotopes in biochemistry, nutrition and clinical medicine: an overview. Isotopes Environ Health Stud 1999; 35: 19-37.
109. 13C breath tests: visions and realities. J Nutr 2001; 131: 1637S-1642S.
110. Bodamer OA, Halliday D. Uses of stable isotopes in clinical diagnosis and research in the paediatric population. Arch Dis Child 2001; 84: 444-448.
111. 13C breath tests in infections and beyond. Food Nutr Bull 2002; 23: 21-29.
112. 13C-breath tests. Food Nutr Bull 2002; 23: 53-56.
113. 2 breath tests for investigating gastrointestinal functions. Food Nutr Bull 2002; 23: 166-168.
114. Wyse CA, Preston T, Yam PS, Sutton DG, Christley RM, Hotchkiss JW, Mills CA, Glidle A, Cumming DR, Cooper JM, Love S. Current and future uses of breath analysis as a diagnostic tool. Vei Rec 2004; 154: 353-360.