Synthesis of 6-[4-(allyl/phenyl)-5-thioxo-1,2,4-triazol-3-yl]pyrimidine-2, 4-diones and their reaction with electrophiles

Chemistry of Heterocyclic Compounds

Volumn 42, Issue 6, 2006, Pages 792-797

  Mekuskiene, G ^a   Vainilavicius, P ^a  

^a VILNIUS UNIVERSITY   (Lithuania)

Author keywords

6 4 (allyl phenyl) 5 thioxo 1,2,4, triazol 3 yl pyrimidine 2,4 diones; 6 bromomethyl 3 (2,4 dioxo 1,2,3,4 tetrahydropyrimidin 6 yl) 5, 6 dihydrothiazolo 2,3 c 1,2,4 triazole; Acetylation; Aminomethylation; Bromination; Methylation

Indexed keywords

EID: 33749023854     PISSN: 00093122     EISSN: 15738353     Source Type: Journal    
DOI: 10.1007/s10593-006-0163-6     Document Type: Article

References (17)

1. D. J. Brown and W. B. Cowden, Austral. J. Chem., 36, 1469 (1983).
2. D. Pancechowska-Ksepko, H. Foks, E. Landowska, M. Janowiec, and Z. Zwolska-Kwiek, Acta Pol. Pharm., 43, 116 (1986).
3. D. Pancechowska-Ksepko, H. Foks, M. Janowiec, and Z. Zwolska-Kwiek, Acta Pol. Pharm., 50, 259 (1993).
4. T. R. Belliotti, D. T. Konnor, and C. R. Costlan, WO Patent 9213884; Chem. Abstr., 118, 6990 (1993).
5. J. M. Kane, B. M. Baron, M. W. Dudley, S. M. Sorensen, M. A. Staeger, and F. P. Miller, J. Med. Chem., 33, 2772 (1990).
6. J. M. Kane and F. P. Miller, US Patent 4912095; Chem. Abstr., 113, 211 (1990).
7. W. Eckhardt, E. Beriger, and H. Zondler, Eur. Patent 371925; Chem. Abstr., 113, 191385 (1990).
8. W. Eckhardt and E. Beriger, Eur. Patent 389426; Chem. Abstr., 114, 102006 (1991).
9. G. Mekuskiene, P. Gaidelis, and P. Vainilavicius, Pharmazie, 53, 94 (1998).
10. G. Mekuskiene, S. Tumkevicius, and P. Vainilavicius, J. Chem. Research (S), 213 (2002).
11. R. Yu. Savickiene, P. I. Vainilavicius, and L. L. Yasinskas, Zh. Vses. Khim. Obshch., 19, 462 (1974).
12. M. Dobosh, A. Pachuta, and J. Rekas. Acta Pol Pharm., 50 (2-3), 228 (1993).
13. P. Renukadevi and J. S. Biradar, Indian J. Heterocycl. Chem., 9, 107 (1999);
14. Chem. Abstr., 132, 293710 (2000).
15. C. L. Angell, J. Chem. Soc., 504 (1961).
16. E. Wittenburg, Chem. Ber., 99, 2380 (1966).
17. J. W. Emsley, J. Feeney, and L. H. Sutcliffe, High Resolution Nuclear Magnetic Resonance Spectroscopy [Russian translation], Vol. 2, Mir, Moscow (1969).