Hepatosplenic γδ T-cell lymphoma with ring chromosome 7, an isochromosome 7q equivalent clonal chromosomal aberration

Virchows Archiv

Volumn 449, Issue 4, 2006, Pages 479-483

  Tamaska, Julia ^a   Adam, Emma ^a   Kozma, Andras ^a   Gopcsa, Laszlo ^a   Andrikovics, Hajnalka ^a   Tordai, Attila ^a   Halm, Gabriella ^a   Bereczki, Laszlo ^b   Bagdi, Eniko ^b   Krenacs, Laszlo ^b  

^a NATIONAL MEDICAL CENTER   (Hungary)

^b BAY ZOLTÁN NONPROFIT LTD FOR APPLIED RESEARCH   (Hungary)

Author keywords

Cytogenetics; FISH; Hepatosplenic T cell lymphoma; Ring chromosome 7

Indexed keywords

ANTINEOPLASTIC AGENT; LACTATE DEHYDROGENASE; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; DNA;

ADULT; ARTICLE; CASE REPORT; CELL MATURATION; CHROMOSOME 7; CHROMOSOME 7Q; CHROMOSOME ABERRATION; CHROMOSOME DELETION; CLINICAL FEATURE; CYTOGENETICS; CYTOTOXIC T LYMPHOCYTE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GASTROINTESTINAL HEMORRHAGE; GENE REARRANGEMENT; HEPATOSPLENIC T CELL LYMPHOMA; HEPATOSPLENOMEGALY; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOCHROMOSOME; LACTATE DEHYDROGENASE BLOOD LEVEL; LYMPHOCYTIC INFILTRATION; PRIORITY JOURNAL; RARE DISEASE; RING CHROMOSOME; T CELL LYMPHOMA; THROMBOCYTOPENIA; TRISOMY 8; BONE MARROW; CELL CLONE; CHEMISTRY; FATALITY; GENETICS; IMMUNOPHENOTYPING; LIVER TUMOR; MIDDLE AGED; PATHOLOGY; POLYMERASE CHAIN REACTION; SPECTRAL KARYOTYPING; SPLEEN TUMOR;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE MARROW; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 7; CLONE CELLS; DNA, NEOPLASM; FATAL OUTCOME; FEMALE; GENE REARRANGEMENT, GAMMA-CHAIN T-CELL ANTIGEN RECEPTOR; HUMANS; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION, FLUORESCENCE; LIVER NEOPLASMS; LYMPHOMA, T-CELL; MIDDLE AGED; POLYMERASE CHAIN REACTION; SPECTRAL KARYOTYPING; SPLENIC NEOPLASMS;

EID: 33749020856     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-006-0267-5     Document Type: Article

References (16)

1. Alonsozana ELC, Stamberg J, Kumar D, Jaffe ES, Medeiros LJ, Frantz C, Schiffer CA, O'Conell BA, Kerman S, Stass SA, Abruzzo LV (1997) Isochromosome 7q: the primary cytogenetic abnormality in hepatosplenic γδ T cell lymphoma. Leukemia 11:1367-1372
2. Belhadj K, Reyes F, Farcet J-P, Tilly H, Bastard C, Angonin R, Deconinck E, Charlotte F, Leblond V, Labouyrie E, Lederlin P, Emile J-F, Delmas-Marsalet B, Arnulf B, Zafrani E-S, Gaulard P (2003) Hepatosplenic γδ T-cell lymphoma is a rare clinicopathological entity with poor outcome: report on a series of 21 patients. Blood 102:4261-4269
3. Cooke CB, Krenacs L, Stetler-Stevenson M, Greiner TC, Raffeld M, Kingma DW, Abruzzo L, Frantz C, Kaviani M, Jaffe ES (1996) Hepatosplenic T-cell lymphoma: a distinct clinicopathologic entity of cytotoxic γδ T-cell origin. Blood 88:4265-4274
4. Farcet JP, Gaulard P, Marolleau JP, Le Couedic J-P, Henni T, Gourdin M-F, Divine M, Haioun C, Yafrani S, Goossens M, Hercend T, Rezes F (1990). Hepatosplenic T-cell lymphoma: sinusal/sinusoidal localization of malignant cells expressing the T-cell receptor γδ. Blood 75:2213-2219
5. Jonveaux P, Daniel MT, Martel V, Maarek O, Berger R (1996) Isochromosome 7q and trisomy 8 are consistent primary nonrandom chromosomal abnormalities associated with hepatosplenic T γδ lymphoma. Leukemia 10:1453-1455
6. Krenacs L, Smyth MJ, Bagdi E, Krenacs T, Kopper L, Rudiger T, Zettl A, Muller-Hermelink HK, Jaffe EJ, Raffeld M (2003) The serine protease granzyme M is preferentially expressed in NK-cell, γδ T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity. Blood 101:3590-3593
7. Lepretre S, Buchonnet G, Stamatoullas A, Lenain P, Duval C, d'Anjou J, Callat M-P, Tilly H, Bastard C (2000) Chromosome abnormalities in peripheral T-cell lymphoma. Cancer Genet Cytogenet 117:71-79
8. McCarthy KP, Sloane JP, Kabarowski JHS, Matutes E, Wiedemann LM (1992) A simplified method of detection of clonal rearrangements of the T-cell receptor-γ chain gene. Diagn Mol Pathol 1:173-179
9. Oscier DG, Gardiner A, Mould S (1996) Structural abnormalities of chromosome 7q in chronic lymphoproliferative disorders. Cancer Genet Cytogenet 92:24-27
10. Przybylski GK, Wu H, Macon WR, Finan J, Leonard DGB, Felgar RE, DiGiuseppe JA, Nowell PC, Swerdlow SH, Kadin ME, Wasik MA, Salhany KE (2000) Hepatosplenic and subcutaneous panniculitis-like γ/δ T cell lymphomas are derived from different Vd subsets of γ/δ T lymphocytes. J Mol Diagnostics 2:11-19
11. Van Dongen JJM, Langerak AW, Brüggemann M, Evans PAS, Hummel M, Lavender FL, Delabesse E, Davi F, Schuuring E, Garcia-Sanz R, van Krieken JH, Droese J, Gonzalez D, Bastard C, White HE, Spaargaren M, Gonzalez M, Parreira A, Smith JL, Morgan GJ, Kneba M, Macintyre EA (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombination in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 17:2257-2317
12. Viaggi S, Abbondandolo A, Carbone M, Ottaggio L, Sessarego M, Zupo S, Zunino A (2004) Uncommon cytogenetic findings in a case of splenic marginal zone lymphoma with aggressive clinical course. Cancer Genet Cytogenet 148:133-136
13. Wang C-C, Tien H-F, Lin M-T, Su I-J, Wang C-H, Chuang S-M, Shen M-C, Liu C-H (1995) Consistent presence of isochromosome 7q in hepatosplenic T γδ lymphoma: a new cytogenetic-clinicopathologic entity. Genes Chromosomes Cancer 12:161-164
14. Weidmann E (2000) Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the dissease as a distinct lymphoma entity in 1990. Leukemia 14:991-997
15. Werner-Favre C, Beris P, Piguet D, Engel E (1986) Ring chromosomes and hematologic disorders. Cancer Genet Cytogenet 23:265-267
16. Wlodarska I, Martin-Garcia N, Achten R, De Wolf-Peeters C, Pauwels P, Tulliez M, de Mascarel A, Briere J, Patey M, Hagelmeijer A, Gaulard P (2002) Fluorescence in situ hybridization study of chromosome 7 aberrations in hepatosplenic T-cell lymphoma: isochromosome 7q as a common abnormality accumulating in forms with features of cytologic progression. Genes Chromosomes Cancer 33:243-251