Teratogenicity of antiepileptic drugs

British Medical Journal

Volumn 333, Issue 7569, 2006, Pages 615-616

  Breen, David P ^a   Davenport, Richard J ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; LAMOTRIGINE; VALPROIC ACID;

CONGENITAL MALFORMATION; DRUG SAFETY; EDITORIAL; EPILEPSY; GESTATION PERIOD; HUMAN; PATIENT COMPLIANCE; PREGNANCY; PRIORITY JOURNAL; RISK FACTOR; SEIZURE; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ANTICONVULSANTS; EPILEPSY; FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS;

EID: 33749011702     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.38961.437639.BE     Document Type: Editorial

References (6)

1. Commission on Genetics, Pregnancy and the Child, International League against Epilepsy. Guidelines for the care of women of childbearing age with epilepsy. Epilepsia 1993;34:588-9.
2. Adab N, Tudur SC, Vinten J, Williamson P, Winterbottom J. Common antiepileptic drugs in pregnancy in women with epilepsy. Cochrane Database Syst Rev 2004;(3):CD004848.
3. Morrow JI, Russell A, Gutherie E, Parsons L, Robertson I, Waddell R, et al. Malformation risks of anti-epileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006;77:193-8.
4. Vajda FJ, O'Brien TJ, Hitchcock A, Graham J, Cook M, Lauder C, et al. Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy. J Clin Neurosci 2004;11:854-8.
5. Wyszynski DF, Nambisan M, Surve T, Alsdorf RM, Smith CR, Holmes LB. Increased rate of major malformations in offspring exposed to valproate during pregnancy. Neurology 2005;64:961-5.
6. Holmes LB, Wyszynski DF, Lieberman E. The AED (Antiepileptic Drug) Pregnancy Registry: a 6-year experience. Arch Neurol 2004;61:673-8.