Merkel cells in the oral mucosa

International Journal of Surgical Pathology

Volumn 14, Issue 3, 2006, Pages 206-211

  Righi, Alberto ^a   Betts, Christine M ^a   Marchetti, Claudio ^a   Marucci, Gianluca ^a   Montebugnoli, Lucio ^a   Prati, Carlo ^a   Eusebi, Leonardo H U ^a   Muzzi, Luciana ^a   Ragazzini, Teresa ^a   Foschini, Maria P ^a,b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b BELLARIA HOSPITAL   (Italy)

Author keywords

Merkel cell; Oral mucosa; Proliferation; Reparative process

Indexed keywords

CHROMOGRANIN A; CYTOKERATIN 20; CYTOKERATIN ANTIBODY; EPITHELIAL MEMBRANE ANTIGEN; KI 67 ANTIGEN; PROTEIN S 100;

ADOLESCENT; ADULT; AGED; ARTICLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CHEEK MUCOSA; CHRONIC INFLAMMATION; ELECTRON MICROSCOPY; ENDOCRINE CELL; EPITHELIUM DYSPLASIA; GINGIVA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LICHEN; MAJOR CLINICAL STUDY; MERKEL CELL; MOUTH CAVITY; MOUTH MUCOSA; NEUROFILAMENT; ORAL BIOPSY; PALATE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SQUAMOUS EPITHELIUM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BIOPSY; CELL COUNT; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; HUMANS; IMMUNOHISTOCHEMISTRY; KERATIN-20; KERATINS; MERKEL CELLS; MIDDLE AGED; MOUTH MUCOSA;

EID: 33749010920     PISSN: 10668969     EISSN: None     Source Type: Journal    
DOI: 10.1177/1066896906290053     Document Type: Article

References (25)

1. Merkel F. Tastzellen und Tastkorperchen bei den Haustieren und beim Menschen. Arch Microsc Anat. 1875;11:636-652.
2. Frigerio B, Capella C, Eusebi V, Tenti P, Azzopardi JG. Merkel cell carcinoma of the skin: the structure and origin of normal Merkel cells. Histopathology. 1983;7(2):229-249.
3. Winkelmann RK, Breathnach AS. The Merkel cell. J Invest Dermatol. 1973;60:2-15.
4. Moll I, Kuhn C, Moll R. Cytokeratin 20 is a general marker of cutaneous Merkel cells while certain neuronal proteins are absent. J Invest Dermatol. 1995;104:910-915.
5. Collina G, Eusebi V, Capella C, Rosai J. Merkel cell differentiation in trichoblastoma. Virchows Arch. 1998;433(4):291-296.
6. Foschini MP, Eusebi V. Divergent differentiation in endocrine and nonendocrine tumors of the skin. Semin Diagn Pathol. 2000;17(2):162-168.
7. Moll I, Roessler M, Brandner JM, Eispert AC, Houdek P, Moll R. Human Merkel cells - aspects of cell biology, distribution and functions. Eur J Cell Biol.2005;84:259-271.
8. Nahass GT, Penneys NS. Merkel cells and prurigo nodularis. J Am Acad Dermatol. 1994;31:86-88.
9. Barrett AW, Cort EM, Patel P, Berkovitz BKB. An immunohistochemical study of cytokeratin 20 in human and mammalian oral epithelium. Arch Oral Biol. 2000;45(10):879-887.
10. Kingsmill VJ, Berkovitz BKB, Barrett AW. An immunohistochemical analysis of human Merkel cell density in gingival epithelium from dentate and edentulous subjects. Arch Oral Biol. 2005;50:883-887.
11. Tachibana T, Kamegai T, Takahashi N, Nawa T. Evidence of polymorphism of Merkel cells in the adult human oral mucosa. Arch Hist Cytol. 1998;61:115-124.
12. Marucci G, Betts CM, Michal M, Foschini MP. Peripheral ameloblastoma with Merkel cells. Virchows Arch. 2005;446(2):204-205.
13. Brown DC, Gatter KC. Monoclonal antibody Ki67. Its use in histopathology. Histopathology. 1990;17:489-507.
14. Gerdes J, Li L, Schlueter C, Duchrow M, et al. Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67. Am J Pathol. 1991;138:867-873.
15. Merot Y, Carraux P, Saurat JH. Merkel cell mitoses in vibrissae: an ultrastructural study. J Anat. 987;153:241-244.
16. Vaigot P, Pisani A, Darmon YM, Ortonne JP. The majority of epidermal Merkel cells are non proliferative: a quantitative immunofluorescence analysis. Acta Derm Venereol (Stockh). 1987;67:515-541.
17. Moll I, Zieger W, Schmets M. Proliferative Merkel cells were not detected in human skin. Arch Dermatol Res. 1996;288:184-187.
18. Chen SY, Gerson S, Meyer J. The fusion of Merkel cells granules with a synapse-like structure. J Invest Dermatol. 1973;61:290-292.
19. Halata Z, Grim M, Bauman KI. Friedrich Sigmund Merkel and his "Merkel cell," morphology, development and physiology: review and new results. Anat Rec A Discov Mol Cell Evol Biol. 2003;271(1):225-239.
20. Nunzi MG, Pisarek A, Mugnaini E. Merkel cells, corpuscular nerve endings and free nerve endings in the mouse palatine mucosa express three subtypes of vesicular glutamate transporters. J Neurocyt. 2004;33:359-376.
21. Tachibana T, Yamamoto H, Takahashi N, et al. Polymorphism of Merkel cells in the rodent palatine mucosa: immunohistochemical and ultrastructural studies. Arch Histol Cytol. 1997;60:379-389.
22. Tachibana T, Nawa T. Recent progress in studies on Merkel cell biology. Anat Sci Int. 2002;77:26-33.
23. Haegerstrand A, Jonzon B, Dalsgaard CJ, Nilsson J. Vasoactive intestinal polypeptide stimulates cell proliferation and adenylate cyclase activity of cultured human keratinocytes. Proc Natl Acad Sci USA. 1989;86:5993-5996.
24. Nilsson J, Euler AN, Dalsgaard CJ. Stimulation of connective tissue cell growth by substance P and substance K. Nature. 1985;315:61-63.
25. Moll I, Bladt U, Jung EG. Presence of Merkel cells in sun-exposed and not sun-exposed skin: a quantitative study. Arch Dermatol Res. 1990;282:213-216.