Effect of thalidomide on the expression of TNF-α m-RNA and synthesis of TNF-α in cells from leprosy patients with reversal reaction

Immunopharmacology and Immunotoxicology

Volumn 28, Issue 3, 2006, Pages 431-441

  Tadesse, Azeb ^a,b,c,e   Abebe, Markos ^a   Bizuneh, Elizabeth ^d   Mulugeta, Wondwossen ^d   Aseffa, Abraham ^a   Shannon, E J ^c  

^a ARMAUER HANSEN RESEARCH INSTITUTE   (Ethiopia)

^b LOUISIANA STATE UNIVERSITY   (United States)

^c LOUISIANA STATE UNIVERSITY   (United States)

^d All Africa Leprosy Tuberculosis and Rehabilitation Training Centre Addis Ababa   (Ethiopia)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPROMIN; MESSENGER RNA; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CYTOKINE PRODUCTION; CYTOSOL; DRUG EFFICACY; DRUG TREATMENT FAILURE; ERYTHEMA NODOSUM; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LEPROSY; MALE; MONONUCLEAR CELL; MYCOBACTERIUM LEPRAE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVERSAL REACTION; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; ANTIGENS, BACTERIAL; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; ERYTHEMA NODOSUM; FEMALE; HUMANS; LEPROMIN; LEPROSY; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MYCOBACTERIUM LEPRAE; PHYTOHEMAGGLUTININS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THALIDOMIDE; TUMOR NECROSIS FACTOR-ALPHA;

MYCOBACTERIUM LEPRAE;

EID: 33748998476     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.1080/08923970600928023     Document Type: Article

References (20)

1. Hastings, R.C. Leprosy; Churchill Livingston, 1985.
2. Laal, S.; Bhutani, L.K.; Nath, I. Natural emergence of antigen-reactive T cells in lepromatous leprosy patients during erythema nodosum leprosum. Infect. Immun. 1985, 50, 887-892.
3. Bjune, G.; Barnetson, R.S.; Ridley, D.S.; Kronvall, G. Lymphocyte transformation test in leprosy; correlation of the response with inflammation of lesions. Clin. Exp. Immunol. 1976, 25, 85-94.
4. Sarno, E.N.; Grau, G.E.; Vieira, L.M.M.; Nery, J.A. Serum levels of tumor necrosis factor-alpha and interleukin-1 β during leprosy reactional states. Clin. Exp. Immunol. 1991, 84, 103-108.
5. Khanolkar-Young, S.; Rayment, N.; Brickell, P.M.; Katz, D.R.; Vinayakumar, S. Tumour necrosis factor-alpha (TNF-α) synthesis is associated with the skin and peripheral nerve pathology of leprosy reversal reactions. Clin. Exp. Immunol. 1995, 99, 196-202.
6. Moubasher, A.E.A.; Kamel, N.A.; Zedan, H.; Abdel Raheem, A.E. Cytokines in leprosy, I. Serum cytokine profile in leprosy. Int. J. Dermatol. 1998, 37, 733-740.
7. Naafs, B. Treatment of leprosy: science of politics? Trop. Med. Int. Health 2006, 11, 268-278.
8. 3H]-thymidine when incubated with M. leprae antigens. Lepr. Rev. 2003, 74, 206-214.
9. Erikson, T. Pharmacokinetics of the enantiomers of thalidomide, PhD Thesis, Department of Clinical Pharmacology, Lund University, Malmö University Hospital, Sweden, 1997.
10. Johnsson, B.J.; McMurray, D.N. Cytokine gene expression by cultures of human lymphocytes with autologous Mycobacterium tuberculosis-infected monocytes. Infect. Immun. 1994, 62, 1444-1450.
11. Wang, A.M.; Doyle, M.V.; Mark, D.F. Quantitation of mRNA by the polymerase chain reaction. Proc. Natl. Acad. Sci. USA 1989, 86, 9717-9721.
12. 3]-thymidine-dependence on a primary stimulant. Int. Immunopharmacol. 2002, 2, 1143-1153.
13. Haslett, P.; Corral, L.; Albert, M.; Kaplan, G. Thalidomide costimulates primary human T lympocytes, preferentially inducing proliferation, cytokine production, and cytotoxin responses in the CD8+ subset. J. Exp. Med. 1998, 187(11), 18850-18892.
14. Marriott, J.B.; Clarke, I.A.; Dredge, K.; Muller, G.; Stirling, D.; Dalgleish, A.G. Thalidomide and its analogues have distinct and opposing effects on TNF-α during stimulation of both CD4+ and CD8+ T cells. Clin. Exp. Immunol. 2002, 130, 75-84.
15. Shannon, E.J.; Sandoval, F. Thalidomide increases the synthesis of IL-2 in cultures of human mononuclear cells stimulated with Concanavalin-A, staphylococcal enterotoxin A, and purified protein derivative. Immunopharmacology 1995, 31, 109-116.
16. Moreira, A.; Sampaio, E.P.; Zmuidzinas, A.; Frindt, P.; Smith, K.A.; Kaplan, G. Thalidomide exerts its inhibitory action on tumor necrosis factor α by enhancing mRNA degradation. J. Exp. Med. 1993, 177, 1675-1680.
17. Sampaio, E.P.; Kaplan, G.; Miranda, A.; Nery, J.A.; Miguel, C.P.; Viana, S.M.; Sarno, E.N. The influence of thalidomide on the clinical and immunologic manifestation of erythema nodosum leprosum. J. Infect. Dis. 1993, 168, 408-414.
18. Shannon, E.J.; Sandoval, F. Thalidomide can be either agonistic or antagonictic to LPS evoked synthesis of TNF-alpha by mononuclear cells. Immunopharmacol. Immunotoxicol. 1996, 18(1), 59-72.
19. Villahermosa, L.G.; Fajardo, T.; Abalos, R.M.; Balagon, M.V.; Tan, E.V.; Cellona, R.V.; Palmer, J.P.; Wittes, J.; Thomas, S.D.; Kook, K.A.; Walsh, G.P.; Walsh, D.S. A randomized, double-blind, double-dummy, controlled dose comparison of thalidomide for treatment of erythema nodosum leprosum. Am. J. Trop. Med. Hyg., 2005, 72(5), 518-526.
20. Haslett, P.A.; Roche, P.; Butlin, C.R.; Macdonald, M.; Shrestha, N.; Manandhar, R.; Lemaster, J.; Hawksworth, R.; Shah, M.; Lubinsky, A.S.; Albert, M.; Worley, J.; Kaplan, G. Effective treatment of erythema nodosum leprosum with thalidomide is associated with immune stimulation. J. Infect. Dis. 2005, 192(12), 2045-2053.