Morphine gel 0.3% does not relieve pain during topical photodynamic therapy: A randomized, double-blind, placebo-controlled study

Acta Dermato-Venereologica

Volumn 86, Issue 5, 2006, Pages 409-411

  Skiveren, Jette ^a   Haedersdal, Merete ^a   Philipsen, Peter Alshede ^a   Wiegell, Stine Regin ^a   Wulf, Hans Christian ^a  

^a BISPEBJERG HOSPITAL   (Denmark)

Author keywords

Actinic keratosis; Basal cell carcinoma; Morphine; Pain; Topical photodynamic therapy

Indexed keywords

MORPHINE; PLACEBO; PROTOPORPHYRIN;

ACTINIC KERATOSIS; ADULT; AGED; ANALGESIA; ARTICLE; BASAL CELL CARCINOMA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CURETTAGE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; EDEMA; FLUORESCENCE ANALYSIS; HUMAN; PAIN; PAIN ASSESSMENT; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SKIN REDNESS; SPECTROPHOTOMETRY; TREATMENT FAILURE; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; AMINOLEVULINIC ACID; CARCINOMA, BASAL CELL; DOUBLE-BLIND METHOD; GELS; HUMANS; KERATOSIS; MIDDLE AGED; MORPHINE; PAIN; PHOTOCHEMOTHERAPY; PHOTOSENSITIVITY DISORDERS; RECEPTORS, OPIOID; SKIN NEOPLASMS;

EID: 33748996758     PISSN: 00015555     EISSN: None     Source Type: Journal    
DOI: 10.2340/00015555-0128     Document Type: Article

References (21)

1. Babilas P, Karrer S, Sidoroff A, Landthaler M, Szeimies RM. Photodynamic therapy in dermatology - an update. Photodermatol Photoimmunol Photomed 2005; 21: 142-149.
2. Morton CA, Brown SB, Collins S, Ibbotson S, Jenkinson H, Kurwa H, et al. Guidelines for topical photodynamic therapy: report of a workshop of the British Photodermatology Group. Br J Dermatol 2002; 146: 552-567.
3. Clark C, Bryden A, Dawe R, Moseley H, Ferguson J, Ibbotson SH. Topical 5-aminolaevulinic acid photodynamic therapy for cutaneous lesions: outcome and comparison of light sources. Photodermatol Photoimmunol Photomed 2003; 19: 134-141.
4. Rhodes LE, de Rie M, Enström Y, Groves R, Morken T, Goulden V, et al. Photodynamic therapy using topical methyl aminolevulinate vs surgery for nodular basal cell carcinoma: results of a multicenter randomized prospective trial. Arch Dermatol 2004; 140: 17-23.
5. Tourna D, Yaar M, Whitehead S, Konnikov N, Gilchrest BA. A trial of short incubation, broad-area photodynamic therapy for facial actinic keratoses and diffuse photodamage. Arch Dermatol 2004; 140: 33-40.
6. Orenstein A, Kostenich G, Tsur H, Kogan L, Malik Z. Temperature monitoring during photodynamic therapy of skin tumors with topical 5-aminolevulinic acid application. Cancer Lett 1995; 93: 227-232.
7. Wiegell SR, Stender IM, Na R, Wulf HC. Pain associated with photodynamic therapy using 5-aminolevulinic acid or 5-aminolevulinic acid methylester on tape-stripped normal skin. Arch Dermatol 2003; 139: 1173-1177.
8. Holmes MV, Dawe RS, Ferguson J, Ibbotson SH. A randomized, double-blind, placebo-controlled study of the efficacy of tetracaine gel (Ametop) for pain relief during topical photodynamic therapy. Br J Dermatol 2004; 150: 337-340.
9. Zeppetella G. Topical opioids for painful skin ulcers: do they work? Eur J Palliative Care 2004; 11: 93-96.
10. Vernassiere C, Cornet C, Trechot P, Alla F, Truchetet F, Cuny JF, et al. Study to determine the efficacy of topical morphine on painful chronic skin ulcers. J Wound Care 2005; 14: 289-293.
11. Rittner HL, Stein C. Involvement of cytokines, chemokines and adhesion molecules in opioid analgesia. Eur J Pain 2005; 9: 109-112.
12. Flock P. Pilot study to determine the effectiveness of diamorphine gel to control pressure ulcer pain. J Pain Symptom Manage 2003; 25: 547-554.
13. Zeppetella G, Paul J, Ribeiro MD. Analgesic efficacy of morphine applied topically to painful ulcers. J Pain Symptom Manage 2003; 25: 555-558.
14. Watterson G, Howard R, Goldman A. Peripheral opioids in inflammatory pain. Arch Dis Child 2004; 89: 679-681.
15. Zeppetella G, Joel SP, Ribeiro MD. Stability of morphine sulphate and diamorphine hydrochloride in intrasite gel. Palliat Med 2005; 19: 131-136.
16. Murphy DF, McDonald A, Power C, Unwin A, MacSullivan R. Measurement of pain: a comprarison of the visual analogue with a nonvisual analogue scale. Clin J Pain 1988; 3:197-199.
17. Breivik EK, Bjornsson GA, Skovlund E. A comparison of pain rating scales by sampling from clinical trial data. Clin J Pain 2000; 16: 22-28.
18. Williamson A, Hoggart B. Pain: a review of three commonly used pain rating scales. J Clin Nurs 2005;14: 798-804.
19. Pagliaro J, Elliott T, Bulsara M, King C, Vinciullo C. Cold air analgesia in photodynamic therapy of basal cell carcinomas and Bowen's disease: an effective addition to treatment: a pilot study. Dermatol Surg 2004; 30: 63-66.
20. Sindrup SH, Jensen TS. Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action. Pain 1999; 83: 389-400.
21. Yeomans DC, Cooper BY, Vierck CJ Jr. Effects of systemic morphine on responses of primates to first or second pain sensations. Pain 1996; 66: 253-263.