Alteration of IgA1 glycosylation by down-regulation of core 1 β1,3-galactosyltransferase and its molecular chaperone Cosmc by Th2 cytokine

Nephrology

Volumn 11, Issue SUPPL. 3, 2006, Pages

  Yamada, Koshi ^a   Kobayashi, Noriyoshi ^a   Ikeda, Tomomi ^b   Tsuge, Toshinao ^a   Suzuki, Yusuke ^a   Horikoshi, Satoshi ^a   Tomino, Yasuhiko ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; CHAPERONE PROTEIN COSMC; CORE 1 BETA1, 3 GALACTOSYLTRANSFERASE; CYTOKINE; GALACTOSYLTRANSFERASE; IMMUNOGLOBULIN A1; UNCLASSIFIED DRUG;

B LYMPHOCYTE; CELLULAR IMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN GLYCOSYLATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH2 CELL;

EID: 33748995926     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/j.1440-1797.2006.00683.x     Document Type: Conference Paper

References (4)

1. Mestecky J, Tomana M, Crowley-Nowick PA, Moldoveanu Z, Julian BA, Jackson S. Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy. Contrib. Nephrol. 1993; 104: 172-182.
2. Chintalacharuvu SR, Emancipator SN. The glycosylation of IgA produced by murine B cells is altered by Th2 cytokines. J. Immunol. 1997; 159: 2327-2333.
3. Ju T, Brewer K, D'Souza A, Cummings RD, Canfield WM. Cloning and expression of human core 1 β1,3-galactosyltransferase. J. Biol. Chem. 2002; 277: 178-186.
4. Ju T, Cummings RD. A unique molecular chaperone Cosmc required for activity of the mammalian core1 β3-galactosyltransferase. Proc. Natl. Acad. Sci. USA 2002; 99: 16 613-16 618.