Anti-tumor activities of the antlered form of Ganoderma lucidum in allogeneic and syngeneic tumor-bearing mice

Bioscience, Biotechnology and Biochemistry

Volumn 70, Issue 9, 2006, Pages 2028-2034

  Nonaka, Yuji ^a   Shibata, Hiroshi ^a   Nakai, Masaaki ^a   Kurihara, Hiroshi ^a,c   Ishibashi, Hiroko ^b   Kiso, Yoshinobu ^a   Tanaka, Takaharu ^a   Yamaguchi, Hideyo ^b   Abe, Shigeru ^b  

^a SUNTORY LTD   (Japan)

^b TEIKYO UNIVERSITY   (Japan)

^c JINAN UNIVERSITY   (China)

Author keywords

Anti tumor activity; Antlered form of Ganoderma lucidum; Cytokine production; Immunodepression; Syngeneic tumor

Indexed keywords

ANTI TUMOR ACTIVITIES; ANTLERED FORM OF GANODERMA LUCIDUM; CYTOKINE PRODUCTION; DRY POWDER PREPARATION; IMMUNODEPRESSION; SYNGENEIC TUMORS;

BIODIVERSITY; DISEASE CONTROL; GROWTH KINETICS; IMMUNOLOGY; NUTRITION;

TUMORS;

ALLOANTIGEN; ANTINEOPLASTIC AGENT; GAMMA INTERFERON; HERBACEOUS AGENT; INTERLEUKIN 4; MM ANTIGEN, MOUSE; TUMOR ANTIGEN;

ANIMAL; ARTICLE; BIOSYNTHESIS; C3H MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHEMISTRY; EXPERIMENTAL NEOPLASM; FLOW CYTOMETRY; GANODERMA LUCIDUM; IMMUNOLOGY; MALE; METHODOLOGY; MOUSE; PHYTOTHERAPY; SARCOMA 180; SURVIVAL;

ANIMALS; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DRUGS, CHINESE HERBAL; FLOW CYTOMETRY; INTERFERON TYPE II; INTERFERON-GAMMA; INTERLEUKIN-4; ISOANTIGENS; MALE; MICE; MICE, INBRED C3H; NEOPLASMS, EXPERIMENTAL; PHYTOTHERAPY; REISHI; SARCOMA 180; SURVIVAL ANALYSIS;

GANODERMA LUCIDUM;

EID: 33748993135     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.50509     Document Type: Article

References (32)

1. Shiao, M. S., Lee, K. R., Lin, L. J., and Wang, C. T., Natural products and biological activities of the Chinese medical fungus, Ganoderma lucidum. In "Food Phytochemicals for Cancer Prevention. II: Teas, Spices, and Herbs," American Chemical Society, eds. Ho, C. T., Osawa, T., Huang, M. T., and Rosen, R. T., Oxford University Press, Washington, DC, pp. 342-354 (1994).
2. Lee, S. Y., and Rhee, H. M., Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem. Pharm. Bull., 38, 1359-1364 (1990).
3. Kimura, Y., Okuda, H., and Arichi, S., Effects of the extracts of Ganoderma lucidum on blood glucose level in rats. Planta Med., 54, 290-294 (1988).
4. Hikino, H., Ishiyama, M., Suzuki, Y., and Konno, C., Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies. Planta Med., 55, 423-428 (1989).
5. Kabir, Y., Kimura, S., and Tamura, T., Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J. Nutr. Sci. Vitaminol., 34, 433-438 (1988).
6. Park, E. J., Ko, G., Kim, J., and Sohn, D. H., Antifibrotic effects of a polysaccharide extracted from Ganoderma lucidum, glycyrrhizin, and pentoxifylline in rats with cirrhosis induced by biliary obstruction. Biol. Pharm. Bull., 20, 417-420 (1997).
7. Kim, D. H., Shim, S. B., Kim, N. J., and Jang, I. S., β-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum. Biol. Pharm. Bull., 22, 162-164 (1999).
8. Tasaka, K., Akagi, M., Miyoshi, K., Mio, M., and Makino, T., Anti-allergic constituents in the culture medium of Ganoderma lucidum. I. Inhibitory effect of oleic acid on histamine release. Agents Actions, 23, 153-156 (1988).
9. Tasaka, K., Mio, M., Izushi, K., Akagi, M., and Makino, T., Anti-allergic constituents in the culture medium of Ganoderma lucidum. II. The inhibitory effect of cyclooctasulfur on histamine release. Agents Actions, 23, 157-160 (1988).
10. Sone, Y., Okuda, R., Wada, N., Kishida, E., and Misaki, A., Structures and antitumor activity of the polysaccharides isolated from fruiting body and growing culture of mycelium of Ganoderma lucidum. Agric. Biol. Chem., 49, 2641-2653 (1985).
11. Maruyama, H., Yamazaki, K., Murofushi, S., Konda, C., and Ikekawa, T., Antitumor activity of Sarcodon aspratus (Berk.) S. Ito and Ganoderma lucidum (Fr.) Karst. J. Pharmacobiodyn., 12, 118-123 (1989).
12. Zhang, L., Zhang, M., Zhou, Q., Chen, J., and Zeng, F., Solution properties of antitumor sulfated derivative of α-(1 → 3)-D-glucan from Ganoderma lucidum. Biosci. Biotechnol. Biochem., 64, 2172-2178 (2000).
13. Bao, X., Liu, C., Fang, J., and Li, X., Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst. Carbohydr. Res., 332, 67-74 (2001).
14. Bao, X., Duan, J., Fang, X., and Fang, J., Chemical modifications of the (1 → 3)-α-D-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity. Carbohydr. Res., 336, 127-140 (2001).
15. Bao, X., Fang, J., and Li, X., Structural characterization and immunomodulating activity of a complex glucan from spores of Ganoderma lucidum. Biosci. Biotechnol. Biochem., 65, 2384-2391 (2001).
16. Bao, X. F., Zhen, Y., Ruan, L., and Fang, J. N., Purification, characterization, and modification of T lymphocyte-stimulating polysaccharide from spores of Ganoderma lucidum. Chem. Pharm. Bull., 50, 623-629 (2002).
17. Min, B. S., Nakamura, N., Miyashiro, H., Bae, K. W., and Hattori, M., Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chem. Pharm. Bull., 46, 1607-1612 (1998).
18. Min, B. S., Gao, J. J., Nakamura, N., and Hattori, M., Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells. Chem. Pharm. Bull., 48, 1026-1033 (2000).
19. Gao, J. J., Min, B. S., Ahn, E. N., Nakamura, N., Lee, H. K., and Hattori, M., New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells. Chem. Pharm. Bull., 50, 837-840 (2002).
20. Ikekawa, T., Beneficial effects of edible and medicinal mushrooms on health care. Int. J. Med. Mushroom, 3, 291-298 (2001).
21. Kohguchi, M., Kunikata, T., Watanabe, H., Kudo, N., Shibuya, T., Ishihara, T., Iwaki, K., Ikeda, M., Fukuda, S., and Kurimoto, M., Immuno-potentiating effects of the antler-shaped fruiting body of Ganoderma lucidum (rokkaku-reishi). Biosci. Biotechnol. Biochem., 68, 881-887 (2004).
22. Ohnishi, M., Kimura, S., Yamazaki, M., Oshima, H., Mizuno, D. I., Abe, S., and Yamaguchi, H., Anti-tumor activity of low-toxicity lipopolysaccharide of Bordetella pertussis. Br. J. Cancer, 69, 1038-1042 (1994).
23. Wang, S. Y., Hsu, M. L., Hsu, H. C., Tzeng, C. H., Lee, S. S., Shiao, M. S., and Ho, C. K., The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int. J. Cancer, 70, 699-705 (1997).
24. Bao, X. F., Wang, X. S., Dong, Q., Fang, J. N., and Li, X. Y., Structural features of immunologically active polysaccharides from Ganoderma lucidum. Phytochemistry, 59, 175-181 (2002).
25. Masuko, Y., Nakajima, H., Tsubouchi, J., Yamazaki, M., Mizuno, D., and Abe, S., Changes of antitumor immunity of hosts with murine mammary tumors regressed by lentinan: potentiation of antitumor delayed hypersensitivity reaction. Gann, 73, 790-797 (1982).
26. Abe, S., Yoshioka, O., Masuko, Y., Tsubouchi, J., Kohno, M., Nakajima, H., Yamazaki, M., and Mizono, D., Combination antitumor therapy with lentinan and bacterial lipopolysaccharide against murine tumors. Gann, 73, 91-96 (1982).
27. Miyaji, C., Ogawa, Y., Imajo, Y., Imanaka, K., and Kimura, S., Combination therapy of radiation and immunomodulators in the treatment of MM 46 tumor transplanted in C3H/He mice. Oncology, 40, 115-119 (1983).
28. Kato, H., Yamamura, Y., Inoue, M., Tanigawa, M., Kimura, S., Sugino, S., and Kondo, M., In vitro augmentation of cytotoxicity by N-CWS in peritoneal polymorphonuclear leukocytes (PMNs) induced by PSK, OK-432 or N-CWS. Biotherapy, 4, 69-73 (1992).
29. Kato, H., Inoue, M., Yamamura, Y., Kawahito, Y., Mukai, S., Sugino, S., and Kondo, M., Effect of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on cytotoxicity of PSK-induced peritoneal polymorphonuclear leukocytes (PMNs). Biotherapy, 5, 177-186 (1992).
30. Sharma, S., Zhu, L., Yang, S. C., Zhang, L., Lin, J., Hillinger, S., Gardner, B., Reckamp, K., Strieter, R. M., Huang, M., Batra, R. K., and Dubinett, S. M., Cyclooxygenase 2 inhibition promotes IFN-γ-dependent enhancement of antitumor responses. J. Immunol., 175, 813-819 (2005).
31. Cryz, S. J., Jr., Furer, E., and Germanier, R., Simple model for the study of Pseudomonas aeruginosa infections in leukopenic mice. Infect. Immun., 39, 1067-1071 (1983).
32. Gamba-Vitalo, C., DiGiovanna, M. P., and Sartorelli, A. C., Effects of recombinant murine granulocyte-macrophage colony-stimulating factor in cyclophosphamide-treated mice. Blood Cells, 17, 193-205 (1991).