Significance of low or normal serum gamma glutamyl transferase level in infants with idiopathic neonatal hepatitis

European Journal of Pediatrics

Volumn 165, Issue 11, 2006, Pages 795-801

  Wang, Jian She ^a   Tan, Nancy ^a   Dhawan, Anil ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Conjugated hyperbilirubinaemia; Gamma glutamyl transferase; Idiopathic neonatal hepatitis; Infants; Prognosis

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GAMMA GLUTAMYLTRANSFERASE;

ANAMNESIS; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CLINICAL FEATURE; CONSANGUINITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC APPROACH ROUTE; DIAGNOSTIC VALUE; ECHOGRAPHY; FEMALE; FOLLOW UP; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GIANT CELL HEPATITIS; HEPATITIS; HISTOPATHOLOGY; HUMAN; IDIOPATHIC DISEASE; INFANT; JAUNDICE; LABORATORY TEST; LIVER BIOPSY; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; NEWBORN HEPATITIS; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; REVIEW; RISK FACTOR;

ASPARTATE AMINOTRANSFERASES; BILIRUBIN; CHOLESTASIS; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HEPATITIS; HUMANS; INFANT; INFANT, NEWBORN; MALE; PROGNOSIS; RETROSPECTIVE STUDIES; SERUM ALBUMIN; STATISTICS, NONPARAMETRIC;

EID: 33748972812     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00431-006-0175-3     Document Type: Review

References (26)

1. Ayling RM, Carragher F (2004) Neonatal biochemical reference ranges. In: Rennie JM (ed) Robertson's textbook of neonatology, 4th edn. Elsevier, Oxford, England
2. Balistreri WF, Bezerra JA (2006) Whatever happened to "neonatal hepatitis"? Clin Liver Dis 10(1):27-53
3. Ballatori N, Truong AT (1995) Multiple canalicular transport mechanisms for glutathione S-conjugates. Transport on both ATP- and voltage-dependent carriers. J Biol Chem 270(8):3594-3601
4. Cabrera-Abreu JC, Green A (2002) Gamma-glutamyltransferase: value of its measurement in paediatrics. Ann Clin Biochem 39(Pt 1):22-25
5. Danks DM, Campbell PE, Jack I, Rogers J, Smith AL (1977) Studies of the aetiology of neonatal hepatitis and biliary atresia. Arch Dis Child 52(2):360-367
6. Dick MC, Mowat AP (1985) Hepatitis syndrome in infancy - an epidemiological survey with 10 year follow up. Arch Dis Child 60(6):512-516
7. Figlewicz DA, Delattre O, Guellaen G, Krizus A, Thomas G, Zucman J, Rouleau GA (1993) Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes. Genomics 17(2):299-305
8. Goodman SI, Mace JW, Pollack S (1971) Serum gamma-glutamyl transpeptidase deficiency. Lancet 1(7692):234-235
9. Hammond JW, Potter M, Wilcken B, Truscott R (1995) Siblings with gamma-glutamyltransferase deficiency. J Inherit Metab Dis 18(1):82-83
10. Hermeziu B, Sanlaville D, Girard M, Léonard C, Lyonnet S, Jacquemin E (2006) Heterozygous bile salt export pump deficiency: a possible genetic predisposition to transient neonatal cholestasis. JPGN 42(1):114-116
11. Holloway PAH, Giles AM (2003) Reference intervals for biochemical data. In: Warrell DA, Cox TM, Firth JD, Benz EJ Jr (eds) Oxford textbook of medicine, 4th edn. Oxford University Press, Oxford, England
12. Jacquemin E, Lykavieris P, Chaoui N, Hadchouel M, Bernard O (1998) Transient neonatal cholestasis: origin and outcome. J Pediatr 133(4):563-567
13. Lockitch G, Halstead AC, Albersheim S, MacCallum C, Quigley G (1998) Age- and sex-specific pediatric reference intervals for biochemistry analytes as measured with the Ektachem-700 analyzer. Clin Chem 34(8):1622-1625
14. Maggiore G, Bernard O, Riely CA, Hadchouel M, Lemonnier A, Allagille D (1987) Normal serum gamma-glutamyl-transpeptidase activity identifies groups of infants with idiopathic cholestasis with poor prognosis. J Pediatr 111(2):251-252
15. Mieli-Vergani G, Howard ER, Mowat AP (1991) Liver disease in infancy: a 20 year perspective. Gut 32(Suppl):S123-S128
16. Moniz C, Nicolaides KH, Keys D, Rodeckt CH (1984) Gamma-glutamyl transferase activity in fetal serum, maternal serum, and amniotic fluid during gestation. J Clin Pathol 37(6):700-703
17. Moss D, Henderson R (1999) Clinical enzymology. In: Burtis CA, Ashwood ER (eds) Tietz textbook of clinical chemistry, 3rd edn. Saunders, Philadelphia, Pennsylvania
18. Priolisi A, Didata M, Fazio M, Gioeli RA (1980) Variations of the serum gamma-glutamyl transpeptidase activity in full-term and pre-term babies during their first two weeks of life. Minerva Pediatrica 32:291-296
19. Rojas E, Valverde M, Kala SV, Kala G, Lieberman MW (2000) Accumulation of DNA damage in the organs of mice deficient in gamma-glutamyltranspeptidase. Mutat Res 14(447):305-316
20. Soldin SJ, Savwoir TV, Guo Y (1997) Pediatric reference ranges for γ-glutamyltransferase (GGT) and urea nitrogen during the first year of life on the Vitros 500 analyzer. Clin Chem Suppl 43:S199
21. Soldin HJ, Hicks JM, Bailey J, Cook JF, Beatey J (1997) Pediatric reference ranges for γ-glutamyltransferase (GGT) on the Hitachi 747 analyzer. Clin Chem Suppl 43:S198
22. Stormon MO, Dorney SF, Kamath KR, O'Loughlin EV, Gaskin KJ (2001)The changing pattern of diagnosis of infantile cholestasis. J Paediatr Child Health 37(1):47-50
23. Taniguchi N, Ikeda Y (1998) Gamma-glutamyl transpeptidase: catalytic mechanism and gene expression. Adv Enzymol Relat Areas Mol Biol 72:239-278
24. Whitfield JB (2001) Gamma glutamyl transferase. Crit Rev Clin Lab Sci 38(4):263-355
25. Will Y, Fischer KA, Horton RA, Kaetzel RS, Brown MK, Hedstrom O, Lieberman MW, Reed DJ (2000) Gamma-glutamyl-transpeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial function, and cellular function. Hepatology 32(4 Pt 1):740-749
26. Wright EC, Stern J, Ersser R, Patrick AD (1980) Glutathionuria: gamma-glutamyl transpeptidase deficiency. J Inherit Metab Dis 2(1):3-7