Epigenetic alterations of BRG1 leads to cancer development through its nuclear-cytoplasmic shuttling abnormalities

Medical Hypotheses

Volumn 67, Issue 6, 2006, Pages 1313-1316

  Gunduz, Esra ^a   Gunduz, Mehmet ^a   Nagatsuka, Hitoshi ^a   Beder, Levent ^a   Demircan, Kadir ^a   Tamamura, Ryo ^a   Hatipoglu, Omer Faruk ^a   Mahmut, Naila ^a   Katase, Naoki ^a   Naomoto, Yoshio ^a   Nagai, Noriyuki ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ENZYME BRG1; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARCINOGENESIS; CELL CYCLE REGULATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; ENZYME ACTIVITY; EPIGENETICS; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE SEQUENCE; HUMAN; MOUTH CANCER; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; NUCLEOSOME; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ACTIVE TRANSPORT, CELL NUCLEUS; ALTERNATIVE SPLICING; CELL NUCLEUS; CYTOPLASM; DNA HELICASES; EPIGENESIS, GENETIC; HUMANS; MODELS, GENETIC; NEOPLASMS; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS;

EID: 33748953340     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.05.032     Document Type: Article

References (21)

1. Narlikar G.J., Fan H.Y., and Kingston R.E. Cooperation between complexes that regulate chromatin structure and transcription. Cell 108 (2002) 475-487
2. Langst G., and Becker P.B. Nucleosome mobilization and positioning by ISWI-containing chromatin-remodeling factors. J Cell Sci 114 (2001) 2561-2568
3. Kingston R.E., and Narlikar G.J. ATP-dependent remodeling and acetylation as regulators of chromatin fluidity. Gene Dev 13 (1999) 2339-2352
4. Burns L.G., and Peterson C.L. The yeast SWI-SNF complex facilitates binding of a transcriptional activator to nucleosomal sites in vivo. Mol Cell Biol 17 (1997) 4811-4819
5. Wu C. Chromatin remodeling and the control of gene expression. J Biol Chem 272 (1997) 28171-28174
6. Muchardt C., and Yaniv M. The mammalian SWI/SNF complex and the control of cell growth. Semin Cell Dev Biol 10 2 (1999) 189-195
7. Holstege F.C., Jennings E.G., Wyrick J.J., Lee T.I., Hengartner C.J., Green M.R., et al. Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95 5 (1998) 717-728
8. Tyler J.K., and Kadonaga J.T. The "dark side" of chromatin remodeling: repressive effects on transcription. Cell 99 5 (1999) 443-446
9. Phelan M.L., Sif S., Narlikar G.J., and Kingston R.E. Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. Mol Cell 3 (1999) 247-253
10. Wang W., Cote J., Xue Y., et al. EMBO J 15 (1996) 5370-5382
11. Bultman S., Gebuhr T., Yee D., La Mantia C., Nicholson J., Gilliam A., et al. A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Mol Cell 6 6 (2000) 1287-1295
12. Reyes J.C., Barra J., Muchardt C., Camus A., Babinet C., and Yaniv M. Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha). EMBO J 17 23 (1998) 6979-6991
13. Muchardt C., and Yaniv M. When the SWI/SNF complex remodels...the cell cycle. Oncogene 20 24 (2001) 3067-3075
14. Barker N., Hurlstone A., Musisi H., Miles A., Bienz M., and Clevers H. The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. EMBO J 20 17 (2001) 4935-4943
15. Wong A.K., Shanahan F., Chen Y., Lian L., Ha P., Hendricks K., et al. BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines. Cancer Res 60 21 (2000) 6171-6177
16. Reisman D.N., Sciarrotta J., Wang W., Funkhouser W.K., and Weissman B.E. Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis. Cancer Res 63 3 (2003) 560-566
17. Gunduz E., Gunduz M., Ouchida M., Nagatsuka H., Beder L., Tsujigiwa H., et al. Genetic and epigenetic alterations of BRG1 promote oral cancer development. Int J Oncol 26 1 (2005) 201-210
18. Hood J.K., and Silver P.A. Diverse nuclear transport pathways regulate cell proliferation and oncogenesis. Biochim Biophys Acta 1471 1 (2000) M31-M41
19. Nouman G.S., Anderson J.J., Crosier S., Shrimankar J., Lunec J., and Angus B. Downregulation of nuclear expression of the p33 (ING1b) inhibitor of growth protein in invasive carcinoma of the breast. J Clin Pathol 56 7 (2003) 507-511
20. Chkheidze A.N., and Liebhaber S.A. A novel set of nuclear localization signals determine distributions of the aCP RNA-binding proteins. Mol Cell Biol 23 (2003) 8405-8415
21. Nakielny S., and Dreyfuss G. The hnRNP C protein contain a nuclear retention sequence that can override nuclear export signals. J Cell Biol 134 (1996) 1365-1373