Concise total synthesis of the marine natural product ageladine A

Organic Letters

Volumn 8, Issue 18, 2006, Pages 4083-4084

  Shengule, Sudhir R ^a   Karuso, Peter ^a  

^a MACQUARIE UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AGELADINE A; PYRROLE DERIVATIVE;

AGELAS; ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

AGELAS; ANIMALS; MOLECULAR STRUCTURE; PYRROLES;

EID: 33748944826     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol061584y     Document Type: Article

References (7)

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3. Heyl, D.; Harris, S. A.; Folkers, K. J. Am. Chem. Soc. 1948, 70, 3429.
4. Aminohistamine (2) is commercially available or can be prepared by several published routes. In this case, the preparation of 2 from Bocguanidine and β-alanine was effected in six steps: (a) Jones, R. G.; Kornfeld, E. C.; McLaughlin, K. C. J. Am. Chem. Soc. 1950, 72, 4526.
5. (b) Little, T. L.; Webber, S. E. J. Org. Chem. 1994, 59, 7299.
6. 4,5-Dibromo-2-formylpyrrole is commercially available, but the preparation of 4 can be effected in near quantitative yield from 2-formylpyrrole in two steps: Handy, S. T.; Sabatini, J. J.; Zhang, Y.; Vulfova, I. Tetrahedron Lett. 2004, 45, 5057.
7. Srinivasan, N.; Ganesan, A. Chem. Commun. 2003, 916.