The negative regulator of splicing element of Rous sarcoma virus promotes polyadenylation

Journal of Virology

Volumn 80, Issue 19, 2006, Pages 9634-9640

  Wilusz, Jeremy E ^a,b   Beemon, Karen L ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; REGULATOR PROTEIN; SMALL NUCLEAR RIBONUCLEOPROTEIN; VIRUS PROTEIN;

ARTICLE; ENVELOPE GENE; GENE INSERTION; GROUP SPECIFIC ANTIGEN GENE; HUMAN; HUMAN CELL; LONG TERMINAL REPEAT; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN PROCESSING; REGULATOR GENE; ROUS SARCOMA ONCOVIRUS; VIRUS GENE;

AVIAN SARCOMA VIRUSES; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; POLYADENYLATION; PROTEIN BINDING; RIBONUCLEOPROTEINS, SMALL NUCLEAR; RNA SPLICING; TERMINAL REPEAT SEQUENCES;

ROUS SARCOMA VIRUS;

EID: 33748934440     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00845-06     Document Type: Article

References (45)

1. Arhin, G., M. Boots, P. Bagga, C. Milcarek, and J. Wilusz. 2002. Downstream sequence elements with different affinities for the hnRNP H/H′ protein influence the processing efficiency of mammalian polyadenylation signals. Nucleic Acids Res. 30:1842-1850.
2. Arrigo, S., and K. Beemon. 1988. Regulation of Rous sarcoma virus RNA splicing and stability. Mol. Cell. Biol. 8:4858-4867.
3. Bagga, P., G. Arhin, and J. Wilusz. 1998. DSEF-1 is a member of the hnRNP H family of RNA-binding proteins and stimulates pre-mRNA cleavage and polyadenylation in vitro. Nucleic Acids Res. 26:5343-5350.
4. Bruzik, J. P., and J. A. Steitz. 1990. Spliced leader RNA sequences can substitute for the essential 5′ end of U1 RNA during splicing in a mammalian in vitro system. Cell. 62:889-999.
5. Cabello-Villegas, J., K. Giles, A. M. Soto, P. Yu, A. Mougin, K. L. Beemon, and Y. X. Wang. 2004. Solution structure of the pseudo-5′ splice site of a retroviral splicing suppressor. RNA 10:1388-1398.
6. Carlberg, K., and K. Beemon. 1988. Proposed gag-encoded transcriptional activator is not necessary for Rous sarcoma virus replication or transformation. J. Virol. 62:4003-4008.
7. Chen, F., and J. Wilusz. 1998. Auxiliary downstream elements are required for efficient polyadenylation of mammalian pre-mRNAs. Nucleic Acids Res. 26:2891-2898.
8. Coffin, J., S. Hughes, and H. Varmus. 1997. Retroviruses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
9. Cook, C., and M. McNally. 1999. Interaction between the negative regulator of splicing element and a 3′ splice site: requirement for U1 small nuclear ribonucleoprotein and the 3′ splice site branch point/pyrimidine tract. J. Virol. 73:2394-2400.
10. Edwards-Gilbert, G., K. Veraldi, and C. Milcarek. 1997. Alternative poly(A) site selection in complex transcription units: means to an end? Nucleic Acids Res. 25:2547-2561.
11. Fogel, B, L. McNally, and M. McNally. 2002. Efficient polyadenylation of Rous sarcoma virus RNA requires the negative regulator of splicing element. Nucleic Acids Res. 30:810-817.
12. Fogel, B., and M. McNally. 2000. A cellular protein, hnRNP H, binds to the negative regulator of splicing element for Rous sarcoma virus. J. Biol. Chem. 275:32371-32378.
13. Giles, K. E, and K. L. Beemon. 2005. Retroviral splicing suppressor sequesters a 3′ splice site in a 50S aberrant splicing complex. Mol. Cell. Biol. 25:4397-4405.
14. Gontarek, R. 1994. A Rous sarcoma virus intronic element negatively regulates splicing by binding snRNPs. Ph.D. thesis. Johns Hopkins University, Baltimore, Md.
15. Gontarek, R. R., M. T. McNally, and K. Beemon. 1993. Mutation of an RSV intronic element abolishes both U11/U12 binding and negative regulation of splicing. Genes Dev. 7:1926-1936.
16. Graveley, B. 2000. Sorting out the complexity of SR protein functions. RNA. 6:1197-1211.
17. Gunderson, S., M. Polucarpou-Schwarz, and I. Mattaj. 1998. U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70k and poly(A) polymerase. Mol. Cell 1:255-264.
18. Guntaka, R. V. 1993. Transcription termination and polyadenylation in retroviruses. Microbiol. Rev. 57:511-521.
19. Herman, S. A., and J. M. Coffin. 1986. Differential transcription from the long terminal repeats of avian leukosis virus DNA. J. Virol. 60:497-505.
20. Hibbert, C., R. Gontarek, and K. Beemon. 1999. The role of overlapping U1 and U11 5′ splice site sequences in a negative regulator of splicing. RNA 5:333-343.
21. Hirose, Y., and J. Manley. 1998. RNA polymerase II is an essential mRNA polyadenylation factor. Nature 395:93-96.
22. Huang, Y., and J. Steitz. 2005. SRprises along a messenger's journey. Mol. Cell 17:613-615.
23. Jiang, W., M. R. Kanter, I. Dunkel, R. G. Ramsay, K. L. Beemon, and W. S. Hayward. 1997. Minimal truncation of the c-myb gene product in rapid-onset B-cell lymphoma. J. Virol. 71:6526-6533.
24. Katz, R. A., and A. M. Skalka. 1990. Control of retroviral RNA splicing through maintenance of suboptimal processing signals. Mol. Cell. Biol. 10: 696-704.
25. Lutz, C., K. Murthy, N. Schek, J. O'Conner, J. Manley, and J. Alwine. 1996. Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro. Genes Dev. 10:325-337.
26. MacDonald, C., and J. Redondo. 2002. Reexamining the polyadenylation signal: were we wrong about AAUAAA? Mol. Cell. Endocrinol. 190:1-8.
27. Mayeda, A., and A. Krainer. 1999. Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing. Methods Mol. Biol. 118:309-314.
28. McCracken, S., N. Fong, K. Yankulov, S. Ballantyne, G. Pan, J. Greenblatt, S. Patterson, M. Wickens, and D. Bentley. 1997. The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. Nature 385:357-361.
29. McCracken, S., D. Longman, I. Johnstone, J. Caceres, and B. Blencowe. 2003. An evolutionarily conserved role for SRm160 in 3′-end processing that functions independently of exon junction complex formation. J. Biol. Chem. 278:44153-44160.
30. McNally, L., and M. McNally. 1996. SR protein factors interact with the Rous sarcoma virus negative regulator of splicing element. J. Virol. 70:1163-1172.
31. McNally, L., and M. McNally. 1998. An RNA splicing enhancer-like sequence is a component of a splicing inhibitor element from Rous sarcoma virus. Mol. Cell. Biol. 18:3103-3111.
32. McNally, L., and M. McNally. 1999. U1 small nuclear ribonucleoprotein and splicing inhibition by the Rous sarcoma virus negative regulator of splicing element. J. Virol. 73:2385-2393.
33. McNally, M., and K. Beemon. 1992. Intronic sequences and 3′ splice sites control Rous sarcoma virus splicing. J. Virol. 66:6-11.
34. Miller, J., and C. M. Stoltzfus. 1992. Two distant upstream regions containing a cis-acting signals regulating splicing facilitate 3′-end processing of avian sarcoma virus RNA. J. Virol. 66:4242-4251.
35. Nesic, D., and L. Maquat. 1994. Upstream introns influence the efficiency of final intron removal and RNA 3′-end formation. Genes Dev. 8:363-375.
36. Niwa, M., S. Rose, and S. Berget. 1990. In vitro polyadenylation is stimulated by the presence of an upstream intron. Genes Dev. 4:1552-1559.
37. Ogert, R. A., L. H. Lee, and K. L. Beemon. 1996. Avian retroviral RNA element promotes unspliced RNA accumulation in the cytoplasm and gag gene expression. J. Virol. 70:3834-3843.
38. O'Sullivan, C., T. Polony, R. Paca, and K. Beemon. 2002. Rous sarcoma virus negative regulator of splicing selectively suppresses src mRNA splicing and promotes polyadenylation. Virology 302:405-412.
39. Paca, R. E., C. S. Hibbert, C. T. O'Sullivan, and K. L. Beemon. 2001. Retroviral splicing suppressor requires three nonconsensus uridines in a 5′ splice site-like sequence. J. Virol. 75:7763-7768.
40. Polony, T., S. Bowers, P. Neiman, and K. Beemon. 2003. Silent point mutation in an avian retrovirus RNA processing element promotes c-myb-associated short-latency lymphomas. J. Virol. 77:9378-9387.
41. Qiu, J., and D. Pintel. 2004. Alternative polyadenylation of adeno-associated virus type 5 RNA within an internal intron is governed by the distance between the promoter and the intron and is inhibited by U1 small nuclear RNP binding to the intervening donor. J. Biol. Chem. 279:14889-14898.
42. Sambrook, J., and D. Russell. 2001. Molecular cloning: a laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
43. Smith, M. R., R. E. Smith, I. Dunkel, V. Hou, K. L. Beemon, and W. S. Hayward. 1997. Genetic determinant of rapid-onset B-cell lymphoma by avian leukosis virus. J. Virol. 71:6534-6540.
44. Vagner, S., C. Vagner, and I. Mattaj. 2000. The carboxy terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3′-end processing and splicing. Genes Dev. 14:403-413.
45. Wilusz, J., and T. Shenk. 1988. A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif. Cell 52:221-228.