Does Pseudomonas aeruginosa colonization influence morbidity and mortality in the intensive care unit patient? Experience from an outbreak caused by contaminated oral swabs

Acta Anaesthesiologica Scandinavica

Volumn 50, Issue 9, 2006, Pages 1095-1102

  Berdal, J E ^a   Smith Erichsen, N ^a   Bjornholt J V ^a   Blomfeldt, A ^a   Bukholm, G ^a  

^a AKERSHUS UNIVERSITY HOSPITAL   (Norway)

Author keywords

Colonization; Intensive care unit; Mortality; Outbreak; Pseudomonas aeruginosa

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; CLINDAMYCIN; ERYTHROMYCIN; MEROPENEM; PENICILLIN DERIVATIVE; PIPERACILLIN PLUS TAZOBACTAM; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; ARTIFICIAL VENTILATION; BACTERIAL COLONIZATION; BACTERIAL INFECTION; BACTERIUM CONTAMINATION; BACTERIUM ISOLATE; CLINICAL ARTICLE; COMORBIDITY; CRITICALLY ILL PATIENT; DISEASE SEVERITY; DISPOSABLE EQUIPMENT; FEMALE; HOSPITAL INFECTION; HUMAN; HUMIDITY; INTENSIVE CARE UNIT; LENGTH OF STAY; MALE; MORTALITY; MOUTH CAVITY; MULTIDRUG RESISTANCE; MULTIPLE ORGAN FAILURE; NORWAY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; VENTILATED PATIENT;

AGED; ANTI-BACTERIAL AGENTS; APACHE; BRONCHOALVEOLAR LAVAGE FLUID; CROSS INFECTION; DISEASE OUTBREAKS; EQUIPMENT CONTAMINATION; FEMALE; GENOTYPE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; NORWAY; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 33748922596     PISSN: 00015172     EISSN: 13996576     Source Type: Journal    
DOI: 10.1111/j.1399-6576.2006.01044.x     Document Type: Article

References (18)

1. Bonten MJM, Bergmans DCJJ, Speijer H, Stobberingh EE. Characteristics of polyclonal endemicity of Pseudomonas aeruginosa colonization rates in intensive care units. Am J Respir Crit Care Med 1999; 160: 1212-9.
2. Moolenar RL, Cruther JM, San Joaquin VH, Sewell LV, Hutwagner LC, Carson LA et al. A prolonged outbreak of Pseudomonas aeruginosa in a neonatal intensive care unit: did staff fingernails play a role in disease transmission? Infect Control Hosp Epidemiol 2000; 21: 80-5.
3. Bukholm G, Tannæs T, Kjelsberg ABB, Smith-Erichsen N. An outbreak of multi-resistant Pseudomonas aeruginosa associated with increased risk of patient death in an intensive care unit. Infect Control Hosp Epidemiol 2000; 23: 441-6.
4. Berthelot P, Grattard F, Mahul P, Pain P, Jospe R, Venet C et al. Prospective study of nosocomial colonization and infection due to Pseudomonas aeruginosa in mechanically ventilated patients. Intensive Care Med 2001; 27: 503-12.
5. Rello J, Rué M, Jubert P, Muses G, Sonora R, Valles J et al. Survival in patients with nosocomial pneumonia: impact of the severity of illness and the etiologic agent. Crit Care Med 1997; 25: 1862-7.
6. Dent-O-Sept Saken. Report 2003: 13. Oslo: The Norwegian Institute of Public Health, 2003.
7. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 1993; 270: 2957-63.
8. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996; 22: 707-10.
9. Knaus WA, Wagner DP, Draper EA, Zimmerman JE, Bergner M, Bastos PG et al. The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest 1991; 100: 1619-36.
10. McCabe WR, Jackson GG. Gram-Negative bacteremia I. Etiology and ecology. Arch Intern Med 1962; 110: 847-52.
11. Boumendil A, Maury E, Reinhard I, Luquel L, Offenstadt G, Guidet B. Prognosis of patients aged 80 years and over admitted in medical intensive care unit. Intensive CareMed 2004; 30: 647-54.
12. Ferreira FL, Peres Bota D, Bross A, Mélot C, Vincent JL. Serial Evaluation of the SOFA Score to Predict Outcome in Critically Ill Patients. JAMA 2001; 286: 1754-8.
13. Doig CJ, Zygun DA, Fick GH, Laupland KB, Boiteau PJE, Shahpori R et al. Study of clinical course of organ dysfunction in intensive care. Crit Care Med 2004; 32: 384-90.
14. Fagon JY, Chastre J, Domart Y, Trouillet JL, Gibert C. Mortality due to ventilator-associated pneumonia or colonization with Pseudomonas or Acinetobacter species: assessment by quantitative culture and samples obtained by a protected specimen brush. Clin Infect Dis 1996; 3: 538-42.
15. Nseir S, Di Pompeo C, Pronnier P, Beague S, Onimus T, Saulnier F et al. Nosocomial tracheobronchitis in mechanically ventilated patients: incidence, aetiology, and outcome. Eur Respir J 2002; 20: 1483-9.
16. Talon D, Blandine M, Rouget C, Bailly P, Thouverez M, Viel JF. Risks and routes for Ventilator-Associated Pneumonia with Pseudomonas aeruginosa. Am J Respir Crit Care Med 1998; 157: 978-84.
17. Rello J, Ausina V, Ricart M, Puzo C, Quintana E, Net A et al. Risk factors for infection by pseudomonas aeruginosa in patients with ventilator-associated pneumonia. Intensive Care Med 1994; 20: 198-203.
18. Trouillet JL, Chastre J, Vuagnat A, Joly-Guillou ML, Combaux D, Dombret MC et al. Ventilator-associated pneumonia caused by potentially drug-resistant bacteria. Am J Respir Crit Care Med 1998; 157: 531-9.