Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes

Acta Tropica

Volumn 99, Issue 1, 2006, Pages 75-82

  Hugosson, Elisabeth ^a,e   Montgomery, Scott M ^b,c   Premji, Zul ^d   Troye Blomberg, Marita ^e   Björkman, Anders ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

^d MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^e STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Antipyretics; Chloroquine; Cytokines; Paracetamol; Plasmodium falciparum malaria; Sulfadoxine pyrimethamine

Indexed keywords

CHLOROQUINE; CYTOKINE; FANSIDAR; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; PARACETAMOL; TUMOR NECROSIS FACTOR ALPHA;

ANTIBIOTICS; DISEASE TREATMENT; MALARIA; MEDICAL GEOGRAPHY; MOSQUITO; PROTEIN;

ANTIPYRETIC ACTIVITY; ARTICLE; BODY TEMPERATURE; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; PARASITEMIA; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; PROTEIN BLOOD LEVEL;

PLASMODIUM FALCIPARUM;

EID: 33748903630     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2006.07.005     Document Type: Article

References (36)

1. Anstey N.M., Weinberg J.B., Hassanali M.Y., Mwaikambo E.D., Manyenga D., Misukonis M.A., Arnelle D.R., Hollis D., McDonald M.I., and Granger D.L. Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J. Exp. Med. 184 (1996) 557-567
2. Brown A.E., Teja-Isavadharm P., and Webster H.K. Macrophage activation in vivax malaria: fever is associated with increased levels of neopterin and interferon-gamma. Parasite Immunol. 13 (1991) 673-679
3. Chaisavaneeyakorn S., Othoro C., Shi Y.P., Otieno J., Chaiyaroj S.C., Lal A.A., and Udhayakumar V. Relationship between plasma interleukin-12 (IL-12) and IL-18 levels and severe malarial anemia in an area of holoendemicity in western Kenya. Clin. Diagn. Lab. Immunol. 10 (2003) 362-366
4. Coban C., Ishii K.J., Kawai T., Hemmi H., Sato S., Uematsu S., Yamamoto M., Takeuchi O., Itagaki S., Kumar N., Horii T., and Akira S. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J. Exp. Med. 201 (2005) 19-25
5. Dinarello C.A. Cytokines as endogenous pyrogens. J. Infect. Dis. 179 (1999) S294-S304
6. Dinarello C.A. Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed. J. Endotoxin Res. 10 (2004) 201-222
7. Ertel W., Morrison M.H., Ayala A., and Chaudry I.H. Chloroquine attenuates hemorrhagic shock-induced suppression of Kupffer cell antigen presentation and major histocompatibility complex class II antigen expression through blockade of tumor necrosis factor and prostaglandin release. Blood 78 (1991) 1781-1788
8. Graham G.G., and Scott K.F. Mechanism of action of paracetamol. Am. J. Ther. 12 (2005) 46-55
9. Grau G.E., Taylor T.E., Molyneux M.E., Wirima J.J., Vassalli P., Hommel M., and Lambert P.H. Tumor necrosis factor and disease severity in children with falciparum malaria. N. Engl. J. Med. 320 (1989) 1586-1591
10. Hong Z., Jiang Z., Liangxi W., Guofu D., Ping L., Yongling L., Wendong P., and Minghai W. Chloroquine protects mice from challenge with CpG ODN and LPS by decreasing proinflammatory cytokine release. Int. Immunopharmacol. 4 (2004) 223-234
11. Hugosson E., Björkman A., and Troye-Blomberg M. Chloroquine enhances the number of IL-10 producing cells and the expression of B7-2 and ICAM-1 in in vitro-cultured PBMC. Scand. J. Immunol. 55 (2002) 399-408
12. Hugosson E., Montgomery S.M., Premji Z., Troye-Blomberg M., and Björkman A. Higher plasma levels of IL-10 are associated with less effective clearance of P. falciparum parasites during treatment. Parasite Immunol. 26 (2004) 111-117
13. Hugosson E., Tarimo D., Troye-Blomberg M., Montgomery S.M., Premji Z., and Björkman A. Antipyretic, parasitologic, and immunologic effects of combining sulfadoxine/pyrimethamine with chloroquine or paracetamol for treating uncomplicated Plasmodium falciparum malaria. Am. J. Trop. Med. Hyg. 69 (2003) 366-371
14. Jakobsen P.H., McKay V., N'Jie R., Olaleye B.O., D'Alessandro U., Bendtzen K., Schousboe I., and Greenwood B.M. Soluble products of inflammatory reactions are not induced in children with asymptomatic Plasmodium falciparum infections. Clin. Exp. Immunol. 105 (1996) 69-73
15. Jeong J.Y., and Jue D.M. Chloroquine inhibits processing of tumor necrosis factor in lipopolysaccharide-stimulated RAW 264.7 macrophages. J. Immunol. 158 (1997) 4901-4907
16. Karres I., Kremer J.P., Dietl I., Steckholzer U., Jochum M., and Ertel W. Chloroquine inhibits proinflammatory cytokine release into human whole blood. Am. J. Physiol. 274 (1998) R1058-R1064
17. Karunaweera N.D., Grau G.E., Gamage P., Carter R., and Mendis K.N. Dynamics of fever and serum levels of tumor necrosis factor are closely associated during clinical paroxysms in Plasmodium vivax malaria. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 3200-3203
18. Kwiatkowski D., Molyneux M.E., Stephens S., Curtis N., Klein N., Pointaire P., Smit M., Allan R., Brewster D.R., Grau G.E., et al. Anti-TNF therapy inhibits fever in cerebral malaria. Q. J. Med. 86 (1993) 91-98
19. Landewe R.B., Miltenburg A.M., Breedveld F.C., Daha M.R., and Dijkmans B.A. Cyclosporine and chloroquine synergistically inhibit the interferon-gamma production by CD4 positive and CD8 positive synovial T cell clones derived from a patient with rheumatoid arthritis. J. Rheumatol. 19 (1992) 1353-1357
20. Lee J., Chuang T.H., Redecke V., She L., Pitha P.M., Carson D.A., Raz E., and Cottam H.B. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 6646-6651 (Epub 2003 May 6648)
21. Leon L.R. Invited review: cytokine regulation of fever: studies using gene knockout mice. J. Appl. Physiol. 92 (2002) 2648-2655
22. Leon L.R., Kozak W., Rudolph K., and Kluger M.J. An antipyretic role for interleukin-10 in LPS fever in mice. Am. J. Physiol. 276 (1999) R81-R89
23. Migot-Nabias F., Luty A.J., Ringwald P., Vaillant M., Dubois B., Renaut A., Mayombo R.J., Minh T.N., Fievet N., Mbessi J.R., Millet P., and Deloron P. Immune responses against Plasmodium falciparum asexual blood-stage antigens and disease susceptibility in Gabonese and Cameroonian children. Am. J. Trop. Med. Hyg. 61 (1999) 488-494
24. Moore K.W., de Waal Malefyt R., Coffman R.L., and O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19 (2001) 683-765
25. Mordmuller B.G., Metzger W.G., Juillard P., Brinkman B.M., Verweij C.L., Grau G.E., and Kremsner P.G. Tumor necrosis factor in Plasmodium falciparum malaria: high plasma level is associated with fever, but high production capacity is associated with rapid fever clearance. Eur. Cytokine Netw. 8 (1997) 29-35
26. Mshana R.N., Boulandi J., Mshana N.M., Mayombo J., and Mendome G. Cytokines in the pathogenesis of malaria: levels of IL-I beta, IL-4, IL-6, TNF-alpha and IFN-gamma in plasma of healthy individuals and malaria patients in a holoendemic area. J. Clin. Lab. Immunol. 34 (1991) 131-139
27. Othoro C., Lal A.A., Nahlen B., Koech D., Orago A.S., and Udhayakumar V. A low interleukin-10 tumor necrosis factor-alpha ratio is associated with malaria anemia in children residing in a holoendemic malaria region in western Kenya. J. Infect. Dis. 179 (1999) 279-282
28. Park J., Kwon D., Choi C., Oh J.W., and Benveniste E.N. Chloroquine induces activation of nuclear factor-kappaB and subsequent expression of pro-inflammatory cytokines by human astroglial cells. J. Neurochem. 84 (2003) 1266-1274
29. Perneger T.V. What's wrong with Bonferroni adjustments. BMJ 316 (1998) 1236-1238
30. Picot S., Peyron F., Donadille A., Vuillez J.P., Barbe G., and Ambroise-Thomas P. Chloroquine-induced inhibition of the production of TNF, but not of IL-6, is affected by disruption of iron metabolism. Immunology 80 (1993) 127-133
31. Rhee M.S., Akanmori B.D., Waterfall M., and Riley E.M. Changes in cytokine production associated with acquired immunity to Plasmodium falciparum malaria. Clin. Exp. Immunol. 126 (2001) 503-510
32. Schofield L., and Hackett F. Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites. J. Exp. Med. 177 (1993) 145-153
33. Seoh J.Y., Khan M., Park S.H., Park H.K., Shin M.H., Ha E.H., Lee B.E., Yoo K., Han H.S., Oh S., Wi J.H., Hong C.K., Oh C.H., Kim Y.A., and Park J.W. Serum cytokine profiles in patients with Plasmodium vivax malaria: a comparison between those who presented with and without hyperpyrexia. Am. J. Trop. Med. Hyg. 68 (2003) 102-106
34. van den Borne B.E., Dijkmans B.A., de Rooij H.H., le Cessie S., and Verweij C.L. Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells. J. Rheumatol. 24 (1997) 55-60
35. Zetterstrom M., Sundgren-Andersson A.K., Ostlund P., and Bartfai T. Delineation of the proinflammatory cytokine cascade in fever induction. Ann. N. Y. Acad. Sci. 856 (1998) 48-52
36. Zou W., Amcheslavsky A., and Bar-Shavit Z. CpG oligodeoxynucleotides modulate the osteoclastogenic activity of osteoblasts via Toll-like receptor 9. J. Biol. Chem. 278 (2003) 16732-16740 (Epub 12003 February 16728)