Lipase AKG mediated resolutions of α,α-disubstituted 1,2-diols in organic solvents; remarkably high regio- and enantio-selectivity

Journal of the Chemical Society - Perkin Transactions 1

Volumn , Issue 16, 1996, Pages 2051-2060

  Hof, Robert P ^a   Kellogg, Richard M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33748897718     PISSN: 0300922X     EISSN: None     Source Type: Journal    
DOI: 10.1039/P19960002051     Document Type: Article

References (42)

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21. (b) the same absolute regioselectivity has been observed before in the PPL catalysed acylation of α-methylphenylglycol. The enantioselectivity of this reaction was, however, low. A. J. M. Janssen, A. J. H. Klunder and B. Zwanenburg, Tetrahedron, 1991, 47, 7409.
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28. We are most grateful to Mr Yoshihiko Hirose of Amano for details of lipase AKG. This lipase is a granular non-immobilized form of lipase AK and is intended for detergent use. Amano reports that the crystallographic structure of lipase AK has not yet been determined but the amino acid sequence is known. Professor R. D. Schmid of the University of Stuttgart has, however, kindly provided us with some information concerning the isolation of a lipase from Pseudomonas sp. by Amano (Y. Kojima, M. Yokoe and T. Mase, Biosci. Biotech. Biochem., 1994, 58, 1564). This specific lipase (AK102) may be related to AK.
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42. Prepared analogously to 4-bromomandelic acid according to ref. 18.