Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues

Journal of Medicinal Chemistry

Volumn 49, Issue 19, 2006, Pages 5845-5848

  Mohler, Michael L ^a   Kang, Gyong Suk ^a   Hong, Seoung Soo ^a   Patil, Renukadevi ^a   Kirichenko, Oleg V ^a   Li, Wei ^a   Rakov, Igor M ^a   Geisert, Eldon E ^b   Miller, Duane D ^a,c  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^c Nashville Clinical Education Center and Statewide   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BIPHENYL 4 YLMETHYL 1,2,3,4 TETRAHYDROISOQUINOLINE 6,7 DIOL; CARMUSTINE; FLUOROURACIL; MELPHALAN; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASTROCYTE; CANCER INHIBITION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; GLIOMA; HUMAN; HUMAN CELL; NERVE CELL CULTURE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; ASTROCYTES; BIPHENYL COMPOUNDS; CELL LINE, TUMOR; CELLS, CULTURED; DRUG SCREENING ASSAYS, ANTITUMOR; GLIOMA; HUMANS; ISOQUINOLINES; MOLECULAR CONFORMATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 33748881591     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060020x     Document Type: Article

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