Assessing the stiffness of spinal fusion in animal models

HSS Journal

Volumn 2, Issue 1, 2006, Pages 12-18

  Cottrell, Jocelyn M ^a,b   Van Der Meulen, Marjolein C H ^a,b   Lane, Joseph M ^b   Myers, Elizabeth R ^b  

^a Cornell University   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

Animal model; Biomechanics; Lumbar spinal fusion; Spine

Indexed keywords

EID: 33748873910     PISSN: 15563316     EISSN: 15563324     Source Type: Journal    
DOI: 10.1007/s11420-005-5123-7     Document Type: Article

References (38)

1. Lipson SJ (2004) Spinal-fusion surgery - advances and concerns. N Engl J Med 350:643-644
2. Katz JN (1995) Lumbar spinal fusion. Surgical rates, costs, and complications. Spine 20:78S-83S
3. Lee C, Dorcil J, Radomisli TE (2004) Nonunion of the spine: a review. Clin Orthop Relat Res 419:71-75
4. Fischgrund JS, Mackay M, Herkowitz HN (1997) 1997 Volvo Award winner in clinical studies. Degenerative lumbar spondy-lolisthesis with spinal stenosis: a prospective, randomized study comparing decompressive laminectomy and arthrodesis with and without spinal instrumentation. Spine 22:2807-2812
5. Steinmann JC, Herkowitz HN (1992) Pseudarthrosis of the spine. Clin Orthop Relat Res 284:80-90
6. DePalma AF, Rothman RH (1968) The nature of pseudarthrosis. Clin Orthop Relat Res 59:113-118
7. Kornblum MB, Fischgrund JS, Herkowitz HN et al (2004) Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective long-term study comparing fusion and pseudarthrosis. Spine 29:726-733; discussion 33-34
8. Sengupta DK, Herkowitz HN (2005) Degenerative spondylolisthesis: review of current trends and controversies. Spine 30:871-S81
9. Hidaka C, Goshi K, Rawlins B et al (2003) Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7-expressing bone marrow cells and allograft bone. Spine 28:2049-2057
10. Muschler GF, Negami S, Hyodo A et al (1996) Evaluation of collagen ceramic composite graft materials in a spinal fusion model. Clin Orthop Relat Res 328:250-260
11. Kotani Y, Cunningham BW, Cappuccino A et al (1998) The effects of spinal fixation and destabilization on the biomechanical and histologic properties of spinal ligaments. An in vivo study. Spine 23:672-682; discussion 82-83
12. Steffen T, Marchesi D, Aebi M (2000) Posterolateral and anterior interbody spinal fusion models in the sheep. Clin Orthop Relat Res 371:28-37
13. Grauer JN, Bomback DA, Lugo R et al (2004) Posterolateral lumbar fusions in athymic rats: characterization of a model. Spine J 4:281-286
14. Boden SD, Schimandle JH, Hutton WC (1995) An experimental lumbar intertransverse process spinal fusion model. Radiographic, histologic, and biomechanical healing characteristics. Spine 20:412-420
15. Sama AA, Khan SN, Myers ER et al (2004) High-dose alendronate uncouples osteoclast and osteoblast function: a study in a rat spine pseudarthrosis model. Clin Orthop Relat Res 425:135-142
16. Grauer JN, Vaccaro AR, Kato M et al (2004) Development of a New Zealand white rabbit model of spinal pseudarthrosis repair and evaluation of the potential role of OP-1 to overcome pseudarthrosis. Spine 29:1405-1412
17. Kim HS, Viggeswarapu M, Boden SD et al (2003) Overcoming the immune response to permit ex vivo gene therapy for spine fusion with human type 5 adenoviral delivery of the LIM mineralization protein-1 cDNA. Spine 28:219-226
18. Suzuki H, Takahashi K, Yamagata M et al (2001) Spatial and temporal collagen gene expression in lumbar intertransverse fusion in the rabbit, J Bone Joint Surg Br 83:760-766
19. Liao SS, Guan K, Cui FZ et al (2003) Lumbar spinal fusion with a mineralized collagen matrix and rhBMP-2 in a rabbit model. Spine 28:1954-1960
20. Yee AJ, Bae HW, Friess D et al (2004) Accuracy and interobserver agreement for determinations of rabbit posterolateral spinal fusion, Spine 29:1308-1313
21. Muschler OF, Huber B, Ullman T et al (1993) Evaluation of bone-grafting materials in a new canine segmental spinal fusion model. J Orthop Res 11:514-524
22. Szivek JA, Robetto RF, Slack JM et al (2002) An implantable strain measurement system designed to detect spine fusion: preliminary results from a biomechanical in vivo study. Spine 27:487-497
23. Beer F, Johnston E (1992) Mechanics of Materials, McGraw-Hill, New York, Chapter 7
24. Tabacknick B, Fidell L (1989) Using Multivariate Statistics. Harper and Row, New York, 63-65
25. Grauer JN, Erulkar JS, Patel TC et al (2000) Biomechanical evaluation of the New Zealand white rabbit lumbar spine: a physiologic characterization. Bur Spine J 9:250-255
26. Blumenthal SL, Gill K (1993) Can lumbar spine radiographs accurately determine fusion in postoperative patients? Correlation of routine radiographs with a second surgical look at lumbar fusions. Spine 18:1186-1189
27. Brodsky AE, Kovalsky ES, Khalil MA (1991) Correlation of radiologic assessment of lumbar spine fusions with surgical exploration. Spine 16:S261-S265
28. Minamide A, Kawakami M, Hashizume H et al (2001) Evaluation of carriers of bone morphogenetic protein for spinal fusion. Spine 26:933-939
29. Boden SD, Martin GJ Jr, Morone M et al (1999) The use of coralline hydroxyapatite with bone marrow, autogenous bone graft, or osteoinductive bone protein extract for posterolateral lumbar spine fusion. Spine 24:320-327
30. Erulkar JS, Grauer JN, Patel TC et al (2001) Flexibility analysis of posterolateral fusions in a New Zealand white rabbit model. Spine 26:1125-1130
31. Spiro RC, Thompson AY, Poser JW (2001) Spinal fusion with recombinant human growth and differentiation factor-5 combined with a mineralized collagen matrix. Anat Rec 263:388-395
32. Glazer PA, Heilmann MR, Lotz JC et al (1997) Use of electromagnetic fields in a spinal fusion. A rabbit model. Spine 22:2351-2356
33. Tay BK, Le AX, Heilman M et al (1998) Use of a collagen-hydroxyapatite matrix in spinal fusion. A rabbit model. Spine 23:2276-2281
34. Muschler GF, Nitto H, Matsukura Y et al (2003) Spine fusion using cell matrix composites enriched in bone marrow-derived cells. Clin Orthop Relat Res 407:102-118
35. ASTM (1997) Standard test methods for flexural properties of unreinforced and reinforced plastics and electrical insulating materials, 790-797
36. Carter DR, Spengler DM (1978) Mechanical properties and composition of cortical bone. Clin Orthop Relat Res 135:192217
37. Lewis G (1997) Properties of acrylic bone cement: state of the art review. J Biomed Mater Res 38:155-182
38. Cammisa FP Jr, Lowery G, Garfin SR et al (2004) Two-year fusion rate equivalency between Grafton DBM gel and autograft in posterolateral spine fusion: a prospective controlled trial employing a side-by-side comparison in the same patient. Spine 29:660-666