Antibiotic Therapy and 48-Hour Mortality for Patients with Pneumonia

American Journal of Medicine

Volumn 119, Issue 10, 2006, Pages 859-864

  Mortensen, Eric M ^a   Restrepo, Marcos I ^a   Anzueto, Antonio ^a   Pugh, Jacqueline A ^a  

^a SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

Antibacterial agents; Community acquired infections; Pneumonia

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPICILLIN; AZITHROMYCIN; BETA LACTAM ANTIBIOTIC; CEFEPIME; CEFOTAXIME; CEFTRIAXONE; CILASTATIN PLUS IMIPENEM; CLARITHROMYCIN; CLINDAMYCIN; DOXYCYCLINE; ERYTHROMYCIN; GATIFLOXACIN; LEVOFLOXACIN; MACROLIDE; MEROPENEM; MOXIFLOXACIN; PIPERACILLIN PLUS TAZOBACTAM; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SULTAMICILLIN; VANCOMYCIN;

ADULT; ANTIBIOTIC THERAPY; ARTICLE; CLINICAL ASSESSMENT; COHORT ANALYSIS; COMMUNITY ACQUIRED PNEUMONIA; CONFIDENCE INTERVAL; CONTROLLED STUDY; COVARIANCE; DRUG USE; FEMALE; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MEDICAL INFORMATION; MEDICAL RESEARCH; MORTALITY; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PRACTICE GUIDELINE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; TEACHING HOSPITAL; TERTIARY HEALTH CARE; UNITED STATES;

ADULT; AGED; ANTI-BACTERIAL AGENTS; COHORT STUDIES; COMMUNITY-ACQUIRED INFECTIONS; FEMALE; GUIDELINE ADHERENCE; HUMANS; MALE; MIDDLE AGED; PATIENT ADMISSION; PNEUMONIA; RETROSPECTIVE STUDIES; RISK ADJUSTMENT; TIME FACTORS;

EID: 33748803938     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjmed.2006.04.017     Document Type: Article

References (27)

1. Austrian R., and Gold J. Pneumococcal bacteremia with special reference to bacteremic pneumococcal pneumonia. Ann Intern Med 60 (1964) 759-776
2. Freid V.M., Prager K., MacKay A.P., and Xia H. Health, United States, 2003 with Chartbook on Trends in the Health of Americans (2003), National Center for Health Statistics, Hyattsville, MD
3. Gilbert K., and Fine M.J. Assessing prognosis and predicting patient outcomes in community-acquired pneumonia. Semin Respir Infect 9 3 (1994) 140-152
4. Society B.T. Guidelines for the management of community-acquired pneumonia in adults admitted to the hospital. Br J Hosp Med 49 5 (1993) 346-350
5. Gialdroni Grassi G., and Bianchi L. Guidelines for the management of community-acquired pneumonia in adults. Italian Society of Pneumology. Italian Society of Respiratory Medicine. Italian Society of Chemotherapy. Monaldi Arch Chest Dis 50 1 (1995) 21-27
6. Niederman M., Bass J.B., Campbell G.D., et al. Guidelines for the initial management of adult with community-acquired pneumonia: diagnosis, assessment of severity, and initial antimicrobial therapy. Am Rev Respir Dis 148 (1993) 1418-1426
7. Niederman M.S., Mandell L.A., Anzueto A., et al. Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Respir Crit Care Med 163 7 (2001) 1730-1754
8. Bartlett J.G., Dowell S.F., Mandell L.A., File Jr. T.M., Musher D.M., and Fine M.J. Practice guidelines for the management of community-acquired pneumonia in adults. Infectious Diseases Society of America. Clin Infect Dis 31 2 (2000) 347-382
9. British Thoracic Society guidelines for the management of community acquired pneumonia in adults. Thorax 56 Suppl 4 (2001) IV1-IV64
10. Mandell L.A., Marrie T.J., Grossman R.F., et al. Summary of Canadian guidelines for the initial management of community-acquired pneumonia: an evidence-based update by the Canadian Infectious Disease Society and the Canadian Thoracic Society. Can Respir J 7 5 (2000) 371-382
11. Gleason P.P., Meehan T.P., Fine J.M., Galusha D.H., and Fine M.J. Associations between initial antimicrobial therapy and medical outcomes for hospitalized elderly patients with pneumonia. Arch Intern Med 159 21 (1999) 2562-2572
12. Houck P.M., MacLehose R.F., Niederman M.S., and Lowery J.K. Empiric antibiotic therapy and mortality among Medicare pneumonia inpatients in 10 Western States: 1993, 1995, and 1997. Chest 119 (2001) 1420-1426
13. Battleman D.S., Callahan M., and Thaler H.T. Rapid antibiotic delivery and appropriate antibiotic selection reduce length of hospital stay of patients with community-acquired pneumonia. Arch Intern Med 162 (2002) 682-688
14. Waterer G.W., Somes G.W., and Wunderink R.G. Monotherapy may be suboptimal for severe bacteremic pneumococcal pneumonia. Arch Intern Med 161 15 (2001) 1837-1842
15. Mortensen E.M., Restrepo M., Anzueto A., and Pugh J. Effects of guideline-concordant antimicrobial therapy on mortality among patients with community-acquired pneumonia. Am J Med 117 10 (2004) 726-731
16. Wunderink R.G., and Waterer G.W. Community-acquired pneumonia: pathophysiology and host factors with focus on possible new approaches to management of lower respiratory tract infections. Infect Dis Clin North Am 18 4 (2004) 743-759 vii
17. Marrie T. Community-acquired Pneumonia (2001), Kluwer Academic, New York, NY
18. Meehan T.P., Fine M.J., Krumholz H.M., et al. Quality of care, process, and outcomes in elderly patients with pneumonia. JAMA 278 23 (1997) 2080-2084
19. Mandell L.A., Bartlett J.G., Dowell S.F., File Jr. T.M., Musher D.M., and Whitney C. Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin Infect Dis 37 11 (2003) 1405-1433
20. Fine M.J., Auble T.E., Yealy D.M., et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med 336 4 (1997) 243-250
21. Stone R.A., Obrosky D.S., Singer D.E., Kapoor W.N., Fine M.J., and Pneumonia Patient Outcomes Research Team (PORT) Investigators. Propensity score adjustment for pretreatment differences between hospitalized and ambulatory patients with community-acquired pneumonia. Med Care 33 4 Suppl (1995) AS56-AS66
22. Klungel O.H., Martens E.P., Psaty B.M., et al. Methods to assess intended effects of drug treatment in observational studies are reviewed. J Clin Epidemiol 57 12 (2004) 1223-1231
23. Rosenbaum P.R., and Rubin D.B. The central role of the propensity score in observational studies for causal effects. Biometrika 70 (1983) 41-55
24. Hosmer D.W., and Lemeshow S. Applied Logistic Regression (1989), John Wiley and sons, New York (Wiley series in probability and mathematical statistics).
25. Brown R.B., Iannini P., Gross P., and Kunkel M. Impact of initial antibiotic choice on clinical outcomes in community-acquired pneumonia: analysis of a hospital claims-made database. Chest 123 (2003) 1503-1511
26. Malone D.C., and Shaban H.M. Adherence to ATS guidelines for hospitalized patients with community-acquired pneumonia. Ann Pharmacother 35 (2001) 1180-1185
27. Shefet D., Robenshtok E., and Leibovici L. Empirical atypical coverage for inpatients with community-acquired pneumonia. Arch Intern Med 165 (2005) 1992-2000