Neuropathology, tremor and electromyogram in rats exposed to manganese phosphate/sulfate mixture

Journal of Applied Toxicology

Volumn 26, Issue 5, 2006, Pages 419-426

  Salehi, Fariba ^a,b   Normandin, Louise ^a   Krewski, Daniel ^b   Kennedy, Greg ^c   Philippe, Suzanne ^a   Zayed, Joseph ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c ÉCOLE POLYTECHNIQUE DE MONTRÉAL   (Canada)

Author keywords

Inhalation exposure; Manganese phosphate sulfate mixture; Neuropathology; Tremor

Indexed keywords

MANGANESE DERIVATIVE; MANGANESE PHOSPHATE; MANGANESE SULFATE; METHYLCYCLOPENTADIENYLMANGANESE TRICARBONYL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CAUDATE NUCLEUS; CELL COUNT; CELL LOSS; COMBUSTION; CONTROLLED STUDY; ELECTRODE; ELECTROMYOGRAM; ENVIRONMENTAL EXPOSURE; EXPOSURE VARIABLE; FRONTAL CORTEX; GASTROCNEMIUS MUSCLE; GLOBUS PALLIDUS; MALE; NERVE CELL; NEUROPATHOLOGY; NEUTRON ACTIVATION ANALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TREMOR;

ADMINISTRATION, INHALATION; AIR POLLUTANTS; ANIMALS; BRAIN; CANADA; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROMYOGRAPHY; MALE; MANGANESE COMPOUNDS; MUSCLE, SKELETAL; NEURONS; ORGANOMETALLIC COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; SULFATES; TREMOR;

EID: 33748800002     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1156     Document Type: Article

References (50)

1. Aschner M, Aschner JL. 1991. Manganese neurotoxicity: cellular effects and blood-brain barrier transport. Neurosci. Biobehav. Rev. 15: 333-340.
2. Beaupré LA, Salehi F, Plamondon P, L'Espérance G, Zayed J. 2004. Physical and chemical characterization of Mn phosphate/sulfate mixture used in an inhalation toxicology study. Inhal. Toxicol. 16: 231-244.
3. Bonilla E. 1984. Chronic manganese intake induces changes in the motor activity of rats. Exp. Neurol. 84: 696-700.
4. Bonilla E, Diez-Ewald M. 1974. Effect of L-dopa on brain concentration of dopamine and homovanillic acid in rat after chronic manganese chloride administration. J. Neurochem. 22: 297-299.
5. Bolté S, Normandin L, Kennedy G, Zayed J. 2004. Human exposure to respirable manganese in outdoor and indoor air in urban and rural areas. J. Toxicol. Environ. Health 67: 459-467.
6. Calne DB, Chu NS, Huang CC, Lu CS, Olanow W. 1994. Manganism and idiopathic Parkinsonism: similarities and differences. Neurology 44: 1583-1586.
7. Chandra SV, Srivastava SP. 1970. Experimental production of early brain lesions in rats by parenteral administration of manganese chloride. Acta Pharmacol. Toxicol. 28: 177-183.
8. Crump KS, Rousseau P. 1999. Results from eleven years of neurological health surveillance at manganese oxide and salt producing plant. NeuroToxicology 20: 273-286.
9. Dorman DC, Struve MF, James RA, Marshall MW, Parkinson CU, Wong BA. 2001. Influence of particle solubility on the delivery of inhaled manganese to the rat brain: manganese sulfate and manganese tetroxide pharmacokinetics following repeated (14 days) exposure. Toxicol. Appl. Pharmacol. 170: 79-87.
10. Frame MD, Milanick MA. 1991. Mn and Cd transport by the Na-Ca exchanger of ferret red blood cells. Am. J. Physiol. 261: 467-475.
11. Frumkin H, Solomon G. 1997. Manganese in the U.S. gasoline supply. Am. J. Ind. Med. 31: 107-115.
12. Gardiner P, Michel R, Browman C, Noble E. 1986. Increased EMG of rat plantaris during locomotion following surgical removal of its synergists. Brain Res. 380: 114-121.
13. Gorell JM, Johnson CC, Rybicki BA, Peterson EL, Kortsha GX, Brown GG, Richardson RJ. 1999. Occupational exposure to manganese, copper, lead, iron, mercury, and zinc and the risk of Parkinson's disease. NeuroToxicology 20: 239-247.
14. Gwiazda RH, Lee D, Sheridan J, Smith DR. 2002. Low cumulative manganese exposure affects striatal GABA but not dopamine. NeuroToxicology 23: 69-76.
15. Hamai D, Bondy SC. 2004. Oxidative basis of manganese neurotoxicity. Ann. N Y Acad. Sci. 1012: 129-141.
16. Huang CC, Chu NS, Lu CS, Chen RS, Calne DB. 1998. Long-term progression in chronic manganism: ten years of follow-up. Neurology 50: 698-700.
17. Huang CC, Lu CS, Chu NS. 1993. Progression after chronic manganese exposure. Neurology 43: 1479-1483.
18. Hughes AJ, Daniel SE, Kilford L, Lees AJ. 1992. Accuracy of clinical diagnosis of idiopathic parkinson's disease: a clinico-pathologic study of 100 cases. J. Neurosurg. Psychiatry 55: 181-184.
19. Jog MS, Lang AE. 1995. Chronic acquired hepatocerebral degeneration: case reports and new insights. Mov. Disord. 10: 714-722.
20. Kennedy G. 1990. Trace element determination in polymers by neutron activation. In Metallization of Polymers, Sacher E, Pireaux J-J, Kowalczyk SP (eds). American Chemical Society: Montreal, Québec, 128-134.
21. Loranger S, Zayed J. 1997. Environmental contamination and human exposure to airborne total and respirable manganese in Montreal. J. Air Waste Manage. Assoc. 47: 983-989.
22. Lucchini R, Apostoli P, Perrone C, Placidi D, Albini E, Migliorati P, Mergler D, Sassine MP, Palmi S, Alessio L. 1999. Long-term exposure to 'low levels' of manganese oxides and neurofunctional changes in ferroalloy workers. NeuroToxicology 20: 287-297.
23. Malecki EA, Devenyi AG, Barron TF, Mosher TJ, Eslinger P, Flaherty-Craig CV, Rossaro L. 1999. Iron and manganese homeostasis in chronic liver disease: relationship to pallidal T1-weighted magnetic resonance signal hyperintensity. NeuroToxicology 20: 647-652.
24. May PM, Linder PW, Williams DR. 1997. Computer simulation of metal-ion equilibrium in biofluids: models for low-molecular weight complex distribution of calcium (II), magnesium (II), manganese (II), iron (II), copper (II), zinc (II), and lead (II) in human plasma. J. Chem. Soc. Dalton Trans. 588-595.
25. Mena I, Marin O, Fuenzalida S, Cotzias GC. 1967. Chronic manganese poisoning. Clinical picture and manganese turnover. Neurology 17: 128-136.
26. Mergler D, Huel G, Bowler R, Iregren A, Belanger S, Baldwin M, Smargiassi A, Martin L. 1994. Nervous system dysfunction among workers with long-term exposure to manganese. Environ. Res. 65: 151-180.
27. Montes S, Alcaraz-Zubeldia M, Muriel P, Rios C. 2001. Striatal manganese accumulation induces changes in dopamine metabolism in the cirrhotic rat. Brain Res. 891: 123-129.
28. Nachtman JP, Tubben RE, Commissaris RL. 1986. Behavioral effects of chronic manganese administration in rats: locomotor activity studies. Neurobehav. Toxicol. Teratol. 8: 711-715.
29. Nagatomo S, Umehara F, Hanada K, Nobuhara Y, Takenaga S, Arimura K, Osame M. 1999. Manganese intoxication during total parenteral nutrition: report of two cases and review of the literature. Neurol. Sci. 162: 102-105.
30. Narita K, Kawasaki F, Kita H. 1990. Mn and Mg influxes through Ca channels of motor nerve terminal are prevented by verapamil in frogs. Brain Res. 510: 289-295.
31. Newland MC, Weiss B. 1992. Persistent effects of manganese on effortful responding and their relationship to manganese accumulation in the primate globus pallidus. Toxicol. Appl. Pharmacol. 113: 87-97.
32. Normandin L, Carrier G, Gardiner PF, Kennedy G, Hazell AS, Mergler D, Butterworth RF, Philippe S, Zayed J. 2002. Assessment of bioaccumulation, neuropathology, and neurobehavior following subchronic (90 days) inhalation in Sprague-Dawley rats exposed to manganese phosphate. Toxicol. Appl. Pharmacol. 183: 135-145.
33. Olanow CW. 2004. Manganese-induced Parkinsonism and Parkinson's disease. Ann. N Y Acad. Sci. 1012: 209-223.
34. Olanow CW, Good PF, Shinotoh H. 1996. Manganese intoxication in the rhesus monkey: a clinical, pathologic, and biochemical study. Neurology 46: 492-498.
35. Pal P, Samii A, Calne DB. 1999. Manganese neurotoxicity: a review of clinical features, imaging and pathology. NeuroToxicology 20: 227-238.
36. Paximos G, Watson C. 1982. The rat brain in stereotaxic coordinates. Academic Press: San Diego.
37. Rodier J. 1955. Manganese poisoning in Moroccan miners. Br. J. Ind. Med. 12: 21-35.
38. Sadek AH, Rauch R, Schulz PE. 2003. Parkinsonism due to manganism in a welder. Intern. J. Toxicol. 22: 393-401.
39. Salehi F, Krewski D, Mergler D, Normandin L, Kennedy G, Philippe S, Zayed J. 2003. Bioaccumulation and locomotor effects of manganese phosphate/sulfate mixture in Sprague-Dawley rats following subchronic (90 days) inhalation exposure. Toxicol. Appl. Pharmacol. 191: 264-271.
40. Scheuhammer AM, Cherian MG. 1985. Effects of heavy metal cations, sulfhydryl reagents and other chemical agents on striatal D2 dopamine receptors. Biochem. Pharmacol. 34: 3405-3413.
41. Spadoni F, Stefani A, Morello M, Lavaroni F, Giacomini P, Sancesari G. 2000. Selective vulnerability of pallidal neurons in the early phases of manganese intoxication. Exp. Brain. Res. 135: 544-551.
42. Takeda A. 2003. Manganese action in brain function. Brain Res. Rev. 41: 9-87.
43. Tjälve H, Henriksson J, Tallkvist J, Larsson BS, Lindquist NG. 1996. Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats. Pharmacol. Toxicol. 79: 347-356.
44. Ulrich CE, Rinehart W, Brandt M. 1979a. Evaluation of the chronic inhalation toxicity of a manganese oxide aerosol. III - Pulmonary function, electromyograms, limb tremor, and tissue manganese data. Am. Ind. Hyg. Assoc. 40: 349-353.
45. Ulrich CE, Rinehart W, Busey W, Dorato MA. 1979b. Evaluation of the chronic inhalation toxicity of a manganese oxide aerosol. II - Clinical observations, hematology, clinical chemistry and histopathology. Am. Ind. Hyg. Assoc. 40: 322-329.
46. Verity MA. 1999. Manganese neurotoxicity: a mechanistic hypothesis. NeuroToxicology 20: 489-497.
47. Vettori M, Gatti R, Orlandini G. 1999. An in vitro model for the assessment of manganese neurotoxicity. Toxicology in Vitro 13: 931-938.
48. Weiss B, Rehul K. 1994. Delayed neurotoxicity: a silent toxicity. In Principles of Neurotoxicology, Chang LW (ed.). Marcel Dekker: New York, 26: 765-784.
49. Wenning GK, Ben-Shlomo Y, Hughes A. 2000. What clinical features are most useful to distinguish definite multiple system atrophy from Parkinson's disease? J. Neurol. Neurosurg. Psychiatry 68: 434-440.
50. Zayed J. 2001. Use of MMT in Canadian gasoline: health and environment issues. Am. J. Ind. Med. 39: 426-433.