Angioscopic differences in neointimal coverage and in persistence of thrombus between sirolimus-eluting stents and bare metal stents after a 6-month implantation

European Heart Journal

Volumn 27, Issue 18, 2006, Pages 2189-2195

  Takano, Masamichi ^a   Ohba, Takayoshi ^a   Inami, Shigenobu ^a   Seimiya, Koji ^a   Sakai, Shunta ^a   Mizuno, Kyoichi ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Neointimal hyperplasia; Stent; Thrombus

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; ORAL ANTIDIABETIC AGENT; RAPAMYCIN; TICLOPIDINE; WARFARIN;

ADULT; AGED; ANGIOSCOPY; ARTERY INTIMA PROLIFERATION; ARTICLE; BARE METAL STENT; CLINICAL ARTICLE; DRUG ELUTING STENT; FEMALE; FOLLOW UP; HUMAN; IMPLANTATION; MALE; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RELAPSE; REOPERATION; STABLE ANGINA PECTORIS; STATISTICAL SIGNIFICANCE; SUDDEN DEATH; THROMBOSIS;

AGED; ANGINA PECTORIS; CORONARY ANGIOGRAPHY; CORONARY THROMBOSIS; CORONARY VESSELS; DRUG IMPLANTS; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERPLASIA; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; OBSERVER VARIATION; RECURRENCE; SIROLIMUS; STENTS; TUNICA INTIMA;

EID: 33748773896     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehl181     Document Type: Article

References (20)

1. Kornowski R, Hong MK, Tio FO, Bramwell O, Wu H, Leon MB. In-stent restenosis: contributions of inflammatory responses and arterial injury to neointimal hyperplasia. J Am Coll Cardiol 1998;31:224-230.
2. Marx SO, Marks AR. Bench to bedside: the development of rapamycin and its application to stent restenosis. Circulation 2001;104:852-855.
3. Suzuki T, Kopia G, Hayashi S, Bailey LR, Llanos G, Wilensky R, Klugherz BD, Papandreou G, Narayan P, Leon MB, Yeung AC, Tio F, Tsao PS, Falotico R, Carter AJ. Stent-based delivery of sirolimus reduces neointimal formation in a porcine coronary model. Circulation 2001;104:1188-1193.
4. Sousa JE, Costa MA, Abizaid A, Abizaid AS, Feres F, Pinto IM, Seixas AC, Staico R, Mattos LA, Sousa AG, Falotico R, Jaeger J, Popma JJ, Serruys PW. Lack of neointimal proliferation after implantation of sirolimus-coated stents in human coronary arteries: a quantitative coronary angiography and three-dimensional intravascular ultrasound study. Circulation 2001;103:192-195.
5. Rensing BJ, Vos J, Smits PC, Foley DP, van den Brand MJ, van den Gissen WJ, de Feijter PJ, Serruys PW. Coronary restenosis elimination with a sirolimus eluting stent: first European human experience with 6-month angiographic and intravascular ultrasonic follow-up. Eur Heart J 2001;22:2125-2130.
6. Morice MC, Serruys PW, Sousa JE, Fajadet J, Ban Hayashi E, Perin M, Colombo A, Schuler G, Barragan P, Guagliumi G, Molnar F, Falotico R, RAVEL Study Group. A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. N Engl J Med 2002;346:1773-1780.
7. Serruys PW, Degertekin M, Tanabe K, Abizaid A, Sousa JE, Colombo A, Guagliumi G, Wijns W, Lindeboom WK, Lighthart J, de Feyter PJ, Morice MC, RAVEL Study Group. Intravascular ultrasound findings in the multicenter, randomized, double-blind RAVEL (Randomized study with the sirolimus-eluting Velocity balloon-expandable stent in the treatment of patients with de novo native coronary artery Lesions) trial. Circulation 2002;106:798-803.
8. Degertekin M, Lemos PA, Lee CH, Tanabe K, Sousa JE, Abizaid A, Regar E, Sianos G, van der Giessen WJ, de Feyter PJ, Wuelfert E, Popma JJ, Serruys PW. Intravascular ultrasound evaluation after sirolimus eluting stent implantation for de novo and in-stent restenosis lesions. Eur Heart J 2004;25:32-38.
9. Sousa JE, Costa MA, Abizaid A, Feres F, Seixas AC, Tanajura LF, Mattos LA, Falotico R, Jaeger J, Popma JJ, Serruys PW. Four-year angiographic and intravascular ultrasound follow-up of patients treated with sirolimus-eluting stents. Circulation 2005;111:2326-2329.
10. McFadden EP, Stabile E, Regar E, Cheneau E, Ong AT, Kinnaird T, Suddath WO, Weissman NJ, Torguson R, Kent KM, Pichard AD, Satler LF, Waksman R, Serruys PW. Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy. Lancet 2004;364:1519-1521.
11. Takano M, Mizuno K. Late coronary thrombosis in a sirolimus-eluting stent due to the lack of neointimal coverage. Eur Heart J 2006;27:1133.
12. Sakai S, Mizuno K, Yokoyama S, Tanabe J, Shinada T, Seimiya K, Takano M, Ohba T, Tomimura M, Uemura R, Imaizumi T. Morphologic changes in infarct-related plaque after coronary stent placement: a serial angioscopy study. J Am Coll Cardiol 2003;42:1558-1565.
13. Takano M, Mizuno K, Yokoyama S, Seimiya K, Ishibashi F, Okamatsu K, Uemura R. Changes in coronary plaque color and morphology by lipid-lowering therapy with atorvastatin: serial evaluation by coronary angioscopy. J Am Coll Cardiol 2003;42:680-686.
14. Okamatsu K, Takano M, Sakai S, Ishibashi F, Uemura R, Takano T, Mizuno K. Elevated troponin T levels and lesion characteristics in non-ST-elevation acute coronary syndromes. Circulation 2004;109:465-470.
15. Takano M, Inami S, Ishibashi F, Okamatsu K, Seimiya K, Ohba T, Sakai S, Mizuno K. Angioscopic follow-up study of coronary ruptured plaques in nonculprit lesions. J Am Coll Cardiol 2005;45:652-658.
16. Finn AV, Kolodgie FD, Harnek J, Guerrero LJ, Acampado E, Tefera K, Skorija K, Weber DK, Gold HK, Virmani R. Differential response of delayed healing and persistent inflammation at sites of overlapping sirolimus- or paclitaxel-eluting stents. Circulation 2005;112:270-278.
17. Takano M, Jang IK, Mizuno K. Neointimal proliferation around malapposed struts of a sirolimus-eluting stent: optical coherence tomography findings. Eur Heart J 2006;27:1763.
18. Welt FGP, Rogers C. Inflammation in the stent era. Atheroscler Thromb Vasc Biol 2002;22:1769-1776.
19. Steffel J, Latini RA, Akhmedov A, Zimmermann D, Zimmerling P, Luscher TF, Tanner FC. Rapamycin, but not FK-506, increases endothelial tissue factor expression. Circulation 2005;112:2002-2011.
20. Asakura M, Ueda Y, Nanto S, Hirayama A, Adachi T, Kitakaze M, Hori M, Kodama K. Remodeling of in-stent neointima, which become thinner and transparent over 3 years: serial angiographic and angioscopic follow-up. Circulation 1998;97:2003-2006.