Hypoattenuation in unenhanced CT reflects histological graft dysfunction and predicts 1-year mortality after living donor liver transplantation

Liver Transplantation

Volumn 12, Issue 9, 2006, Pages 1403-1411

  Cho, Jai Young ^a   Suh, Kyung Suk ^a   Lee, Hae Won ^a   Cho, Eung Ho ^a   Yang, Sung Hoon ^a   Cho, Yong Beom ^a   Yi, Nam Joon ^a   Kim, Min A ^a   Jang, Ja June ^a   Lee, Kuhn Uk ^a  

^a Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

IOPROMIDE;

ADULT; AGED; ARTICLE; CHOLESTASIS; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CONFIDENCE INTERVAL; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CORRELATION FUNCTION; DEATH; DIAGNOSTIC VALUE; FATTY LIVER; FEMALE; GRAFT DYSFUNCTION; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT SURVIVAL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER CELL CARCINOMA; LIVER FAILURE; LIVER FIBROSIS; LIVER PARENCHYMA; LIVER TRANSPLANTATION; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; POSTOPERATIVE PERIOD; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RADIATION ATTENUATION; ROC CURVE; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; STATISTICAL SIGNIFICANCE; SURGICAL MORTALITY; SURVIVAL RATE;

ADULT; AGED; FEMALE; HUMANS; LIVER; LIVER TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 33748771191     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.20772     Document Type: Article

References (25)

1. Kiuchi T, Tanaka K, Ito T, Oike F, Ogura Y, Fujimoto Y, et al. Small-for-size graft in living donor liver transplantation: how far should we go? Liver Transpl 2003;9(suppl): S29-S35.
2. Thuluvath PJ, Yoo HY. Graft and patient survival after adult live donor liver transplantation compared to a matched cohort who received a deceased donor transplantation. Liver Transpl 2004;10:1263-1268.
3. Dahm F, Georgiev P, Clavien PA. Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications.Am J Transplant 2005;5: 2605-2610.
4. Quiroga S, Sebastia MC, Margarit C, Castells L, Boye R, Alvarez-Castells A. Complications of orthotopic liver transplantation: spectrum of findings with helical CT. Radiographics 2001;21:1085-1102.
5. Tian Y, Graf R, Jochum W, Clavien PA. Arterialized partial orthotopic liver transplantation in the mouse: a new model and evaluation of the critical liver mass. Liver Transpl 2003;9:789-795.
6. Ametani F, Itoh K, Shibata T, Maetani Y, Tanaka K, Konishi J. Spectrum of CT findings in pediatric patients after partial liver transplantation. Radiographics 2001;21:53-63.
7. Man K, Fan ST, Lo CM, Liu CL, Fung PC, Liang TB, et al. Graft injury in relation to graft size in right lobe live donor liver transplantation: a study of hepatic sinusoidal injury in correlation with portal hemodynamics and intragraft gene expression. Ann Surg 2003;237:256-264.
8. Boillot O, Mechet I, Le Derf Y, Bernard P, Figueiredo P, Berger F, et al. Portomesenteric disconnection for small-for-size grafts in liver transplantation: Preclinical studies in pigs. Liver Transpl 2003;9(suppl):S42-S46.
9. Cho JY, Suh KS, Kwon CH, Yi NJ, Cho SY, Jang JJ, et al. The hepatic regeneration power of mild steatotic grafts is not impaired in living-donor liver transplantation. Liver Transpl 2005;11:210-217.
10. Limanond P, Raman SS, Lassman C, Sayre J, Ghobrial RM, Busuttil RW, et al. Macrovesicular hepatic steatosis in living related liver donors: correlation between CT and histologic findings. Radiology 2004;230:276-280.
11. Cho JY, Suh KS, Kwon CH, Yi NJ, Lee KU. Mild hepatic steatosis is not a major risk factor for hepatectomy and regenerative power is not impaired. Surgery 2006; in press.
12. Piekarski J, Goldberg HI, Royal SA, Axel L, Moss AA. Difference between liver and spleen CT numbers in the normal adult: its usefulness in predicting the presence of diffuse liver disease. Radiology 1980;137:727-729.
13. Hubscher S. Diagnosis and grading of liver allograft rejection: a European perspective. Transplant Proc 1996;28: 504-507.
14. Hassoun Z, Shah V, Lohse CM, Pankratz VS, Petrovic LM. Centrilobular necrosis after orthotopic liver transplantation: association with acute cellular rejection and impact on outcome. Liver Transpl 2004;10:480-487.
15. Sugawara Y, Makuuchi M. Small-for-size graft problems in adult-to-adult living-donor liver transplantation. Transplantation 2003;75(suppl):S20-S2.
16. Ben-Haim M, Emre S, Fishbein TM, Sheiner PA, Bodian CA, Kim-Schluger L, et al. Critical graft size in adult-to-adult living donor liver transplantation: impact of the recipient's disease. Liver Transpl 2001;7:948-953.
17. Turlin B, Slapak GI, Hayllar KM, Heaton N, Williams R, Portmann B. Centrilobular necrosis after orthotopic liver transplantation: a longitudinal clinicopathologic study in 71 patients. Liver Transpl Surg 1995;1:285-289.
18. Khettry U, Backer A, Ayata G, Lewis WD, Jenkins RL, Gordon FD. Centrilobular histopathologic changes in liver transplant biopsies. Hum Pathol 2002;33:270-276.
19. Demetris AJ. Central venulitis in liver allografts: considerations of differential diagnosis. Hepatology 2001;33: 1329-1330.
20. Neil DA, Hubscher SG. Are parenchymal changes in early post-transplant biopsies related to preservation-reperfusion injury or rejection? Transplantation 2001;71:1566-1572.
21. Selzner M, Clavien PA. Fatty liver in liver transplantation and surgery. Semin Liver Dis 2001;21:105-113.
22. Selzner N, Selzner M, Jochum W, Amann-Vesti B, Graf R, Clavien P-A. Mouse livers with macrosteatosis are more susceptible to normothermic ischemic injury than those with microsteatosis. J Hepatol 2006;44:694-701.
23. Pizarro M, Balasubramaniyan N, Solis N, Solar A, Duarte I, Miquel JF, et al. Bile secretory function in the obese Zucker rat: evidence of cholestasis and altered canalicular transport function. Gut 2004;53:1837-1843.
24. Ben-Ari Z, Pappo O, Mor E. Intrahepatic cholestasis after liver transplantation. Liver Transpl 2003;9:1005-1018.
25. Ng IO, Burroughs AK, Rolles K, Belli LS, Scheuer PJ. Hepatocellular ballooning after liver transplantation: a light and electronmicroscopic study with clinicopathological correlation. Histopathology 1991;18:323-330.