Morbidity indicators of Schistosoma mansoni: Relationship between infection and anemia in Ugandan schoolchildren before and after praziquantel and albendazole chemotherapy

American Journal of Tropical Medicine and Hygiene

Volumn 75, Issue 2, 2006, Pages 278-286

  Koukounari, Artemis ^a   Fenwick, Alan ^a   Whawell, Sarah ^a   Kabatereine, Narcis B ^b   Kazibwe, Francis ^b   Tukahebwa, Edridah M ^b   Stothard, J Russell ^c   Donnelly, Christl A ^d   Webster, Joanne P ^a  

^a St Mary's Campus ^*  (United Kingdom)

^b MINISTRY OF HEALTH   (Uganda)

^c DEPARTMENT OF LIFE SCIENCES   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; PRAZIQUANTEL; ANTHELMINTIC AGENT; HEMOGLOBIN;

ADOLESCENT; ANEMIA; ARTICLE; DOSE RESPONSE; DRUG TOLERABILITY; FEMALE; FOLLOW UP; HEALTH PROGRAM; HEALTH SURVEY; HEMOGLOBIN BLOOD LEVEL; HOOKWORM INFECTION; HUMAN; INFECTION; MAJOR CLINICAL STUDY; MALE; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SCHOOL CHILD; SINGLE DRUG DOSE; UGANDA; ANIMAL; CHILD; COMPARATIVE STUDY; FECES; ISOLATION AND PURIFICATION; MORBIDITY; PARASITOLOGY; PREVALENCE; RISK;

ANCYLOSTOMATOIDEA; SCHISTOSOMA MANSONI;

ADOLESCENT; ALBENDAZOLE; ANEMIA; ANIMALS; ANTHELMINTICS; CHILD; FECES; FEMALE; HEMOGLOBINS; HUMANS; MALE; MORBIDITY; ODDS RATIO; PRAZIQUANTEL; PREVALENCE; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; UGANDA;

EID: 33748754876     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2006.75.278     Document Type: Article

References (37)

1. Crawley J, 2004. Reducing the burden of anemia in infants and young children in malaria-endemic countries of Africa: from evidence to action. Am J Trop Med Hyg 71: 25-34.
2. Engels D, Chitsulo L, Montresor A, Savioli L, 2002. The global epidemiological situation of schistosomiasis and new approaches to control and research. Acta Trop 82: 139-146.
3. Coutinho HM, McGarvey ST, Acosta LP, Manalo DL, Langdon GC, Leenstra T, Kanzaria HK, Solomon J, Wu H, Olveda RM, Kurtis JD, Friedman JF, 2005. Nutritional status and serum cytokine profiles in children, adolescents, and young adults with Schistosoma japonicum-associated hepatic fibrosis, in Leyte, Philippines. J Infect Dis 192: 528-536.
4. Nokes C, McGarvey ST, Shiue L, Wu G, Wu H, Bundy DA, Olds GR, 1999. Evidence for an improvement in cognitive function following treatment in Schistosoma japonicum infection in chinese primary schoolchildren. Am J Trop Med Hyg 60: 556-565.
5. Olsen A, Magnussen P, Ouma JH, Andreassen J, Friis H, 1998. The contribution of hookworm and other parasitic infections to haemoglobin and iron status among children and adults in western Kenya. Trans R Soc Trop Med Hyg 92: 643-649.
6. Stephenson LS, Holland C, 1987. The Impact of Helminth Infections on Human Nutrition. London, UK: Taylor and Frances.
7. Stephenson LS, 1993. The impact of schistosomiasis on human nutrition. Parasitology 107: 107-123.
8. Preston JM, Dargie JD, 1975. Mechanisms involved in ovine schistosomal anaemia Welsh CN, ed. Nuclear Techniques in Helminthology Research. Vienna, Austria: International Atomic Energy Agency, 121-126.
9. Foy H, Nelson GS, 1963. Helminths in the etiology of anaemia in the tropics, with special reference to hookworms and schistosomes. Exp Parasitol 14: 240-262.
10. Latham MC, Stephenson LS, Hall A, Wolgemuth JC, Elliot TC, Crompton DW, 1983. Parasitic infections, anaemia and nutritional status: a study of their interrelationships and the effect of prophylaxis and treatment on workers in Kwale District, Kenya. Trans R Soc Trop Med Hyg 77: 41-48.
11. Vennervald BJ, Dunne DW, 2004. Morbidity in Schistosomiasis: an update. Curr Opin Infect Dis 17: 439-447.
12. Lengeler C, Kilima P, Mshinda H, Morona D, Hatz C, Tanner M, 1991. Rapid, low-cost, two-step method to screen for urinary schistosomiasis at the district level: the Kilosa experience. Bull World Health Organ 69: 179-189.
13. Utzinger J, N'Goran EK, Esse Aya CM, Acka Adjoua C, Lohourignon KL, Tanner M, Lengeler C, 1998. Schistosoma mansoni, intestinal parasites and perceived morbidity indicators in schoolchildren in a rural endemic area of western Côte d'Ivoire. Trop Med Int Health 3: 711-720.
14. Brouwer KC, Ndhlovu PD, Wagatsuma Y, Munatsi A, Shiff CJ, 2003. Epidemiological assessment of Schistosoma haematobium-induced kidney and bladder pathology in rural Zimbabwe. Acta Trop 85: 339-347.
15. Richter J, 2003. The impact of chemotherapy on morbidity due to schistosomiasis. Acta Trop 86: 161-183.
16. Booth M, Vennervald BJ, Kabatereine NB, Kazibwe F, Ouma JH, Kariuki CH, Muchiri E, Kadzo H, Ireri E, Kimani G, Mwatha JK, Dunne DW, 2004. Hepatosplenic morbidity in two neighbouring communities in Uganda with high levels of Schistosoma mansoni infection but very different durations of residence. Trans R Soc Trop Med Hyg 98: 125-136.
17. Kabatereine NB, Kemijumbi J, Ouma JH, Sturrock RF, Butterworth AE, Madsen H, Ornbjerg N, Dunne DW, Vennnervald BJ, 2003. Efficacy and side effects of praziquantel treatment in a highly endemic Schistosoma mansoni focus at Lake Albert, Uganda. Trans R Soc Trop Med Hyg 97: 599-603.
18. Kabatereine NB, Vennervald BJ, Ouma JH, Kemijumbi J, Butterworth AE, Dunne DW, Fulford AJ, 1999. Adult resistance to schistosomiasis mansoni: age dependence of reinfection remains constant in communities with diverse exposure patterns. Parasitology 118: 101-105.
19. Brooker S, Whawell S, Kabatereine NB, Fenwick A, Anderson RM, 2004. Evaluating the epidemiological impact of national control programmes for helminths. Trends Parasitol 20: 537-545.
20. Stothard JR, Kabatereine NB, Tukahebwa EM, Kazibwe F, Rollinson D, Mathieson W, Webster JP, Fenwick A, 2006. Use of circulating cathodic antigen (CCA) dipsticks for detection of intestinal and urinary schistosomiasis. Acta Trop. 97: 219-228.
21. Kabatereine NB, Tukahebwa EM, Kazibwe F, Twa-Twa JM, Barenzi JF, Zaramba S, Stothard JR, Fenwick A, Brooker S, 2005. Soil-transmitted helminthiasis in Uganda: epidemiology and cost of control. Trop Med Int Health 10: 1187-1189.
22. Parker DR, Bargiota A, Cowan FG, Corrall RJ, 1997. Suspected hypoglycaemia in out patient practice: accuracy of dried blood spot analysis. Clin Endocrinol 47: 679-683.
23. van der Werf MJ, de Vlas SJ, Brooker S, Looman CW, Nagelkerke NJ, Habbema JD, Engels D, 2003. Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa. Acta Trop 86: 125-139.
24. Mauny F, Viel JF, Handschumacher P, Sellin B, 2004. Multilevel modelling and malaria: a new method for an old disease. Int J Epidemiol 33: 1337-1344.
25. Verbeke G, Molenberghs G, 2000. Linear Mixed Models for Longitudinal Data. New York: Springer Series in Statistics.
26. Gibson R, 1990. Principles of Nutritional Assessment. New York: Oxford University Press.
27. Gorstein J, Sullivan K, Yip R, de Onis M, Trowbridge F, Fajans P, Clugston G, 1994. Issues in the assessment of nutrition status using anthropometry. Bull World Health Organ 72: 273-283.
28. World Health Organization, 1995. Physical status: the use and interpretation of anthropometry. World Health Organ Tech Rep Ser: 854.
29. Friedman JF, Kanzaria HK, McGarvey ST, 2005. Human schistosomiasis and anaemia: (the relationship and potential mechanisms. Trends Parasitol 21: 386-392.
30. Kabatereine NB, Tukahebwa E, Kazibwe F, Namwangye H, Zaramba S, Brooker S, Stothard JR, Kamenka C, Whawell S, Webster JP, Fenwick A, 2006. Progress towards countrywide control of schistosomiasis and soil-transmitted helminthiasis in Uganda. Trans R Soc Trop Med Hyg 100: 208-215.
31. Nullis-Kapp C, 2004. Darfur overshadows "forgotten" crisis in neighbouring Uganda. Bull World Health Organ 82: 886.
32. Taylor M, Jinabhai CC, Couper I, Kleinschmidt I, Jogessar B, 2001. The effect of different anthelmintic treatment regimens combined with iron supplementation on the nutritional status of schoolchildren in KwaZulu-Natal South Africa: a randomized control trial. Trans R Soc Trop Med Hyg 95: 211-216.
33. Stoltzfus RJ, Albonico M, Chwaya HM, Tielsch JM, Schulze KJ, Savioli L, 1998. Effects of the Zanzibar school-based deworming program on iron status of children. Am J Clin Nutr 68: 179-186.
34. Beasley NMR, Tomkins AM, Hall A, Kihamia CM, Lorri W, Nduma B, Issae W, Nokes C, Bundy DAP, 1999. The impact of population level deworming on the haemoglobin level of schoolchildren in Tanga, Tanzania. Trop Med Int Health 4: 744-750.
35. Friis H, Mwaniki D, Omondi B, Muniu E, Thiong'o F, Ouma J, Magnussen P, Geissler PW, Michaelsen KF, 2003. Effects on haemoglobin of multi-micronutrient supplementation and multi-helminth chemotherapy: a randomized, control trial in Kenyan schoolchildren. Eur J Clin Nutr 57: 573-579.
36. Uganda Ministry of Health, Available at http://www.health.go.ug/ blood_trans.htm.
37. Kabatereine NB, Brooker S, Tukahebwa EM, Kazibwe F, Onapa AW, 2004. Epidemiology and geography of Schistosoma mansoni in Uganda: implications for planning control. Trop Med Int Health 9: 372-380.