The effect of androgen blockade on granulosa cell estradiol production after follicle-stimulating hormone stimulation in women with polycystic ovary syndrome

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 9, 2006, Pages 3503-3506

  Mehta, Rinku V ^a   Malcom, Pamela J ^a   Chang, R Jeffrey ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ANDROGEN; ANDROSTENEDIONE; ANTIANDROGEN; ASPARTATE AMINOTRANSFERASE; ESTRADIOL; ESTRONE; FLUTAMIDE; FOLLITROPIN; HYDROXYPROGESTERONE; LUTEINIZING HORMONE; PRASTERONE SULFATE; PROGESTERONE; RECOMBINANT FOLLITROPIN; TESTOSTERONE;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL ARTICLE; DRUG EFFECT; FEMALE; GRANULOSA CELL; HUMAN; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; SIDE EFFECT;

EID: 33748746146     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-0752     Document Type: Article

References (21)

1. Erickson GF, Magoffin DA, Garzo VG, Cheung AP, Chang RJ 1992 Granulosa cells of polycystic ovaries: are they normal or abnormal? Hum Reprod 7:293-299
2. Coffler MS, Patel K, Dahan MH, Malcom PJ, Kawashima T, Deutsch R, Chang RJ 2003 Evidence for abnormal granulosa cell responsiveness to follicle-stimulating hormone in women with polycystic ovary syndrome. J Clin Endocrinol Metab 88:1742-1747
3. Almahbobi G, Anderiesz C, Hutchinson P, McFarlane JR, Wood C, Trounson AO 1996 Functional integrity of granulosa cells from polycystic ovaries. Clin Endocrinol (Oxf) 44:571-580
4. Weil SJ, Vendola KA, Zhou J, Bondy CA 1999 Androgen and follicle-stimulating hormone interactions in primate ovarian follicle development. J Clin Endocrinol Metab 84:2951-2956
5. Vendola KA, Zhou J, Oluyemisi AO, Weil SJ, Bondy CA, 1998 Androgens stimulate early stages of follicular growth in the primate ovary. J Clin Endocrinol Metab 101:2622-2629
6. Hillier SG, De Zwart FA 1981 Evidence that granulosa cell aromatase induction/activation by follicle-stimulating hormone is an androgen receptor-regulated process in vitro. Endocrinology 109:1303-1305
7. Harlow CR, Shaw HS, Hillier SG, Hodges JK 1988 Factors influencing follicle-stimulating hormone-responsive steroidogenesis in marmoset granulosa cells: effects of androgen and the stage of follicular maturation. Endocrinology 122:2780-2787
8. Futterweit W, Deligdisch L 1986 Histopathological effects of exogenously administered testosterone in 19 female to male transsexuals. J Clin Endocrinol Metab 62:16-21
9. Pache TD, Chadha S, Gooren LJG, Hop WCJ, Jaarsma KW, Dommerholt HBR, Fauser BC 1991 Ovarian morphology in long term androgen treated female to male transsexuals. A human model for the study of polycystic ovary syndrome? Histopathology 19:445-452
10. Pache TD, Fauser BC 1993 Polycystic ovaries in female to male transsexuals. Clin Endocrinol (Oxf) 39:702-703
11. Nimrod A 1977 Studies on the synergistic effect of androgen on the stimulation of progestin secretion by FSH in cultured rat granulosa cells: progesterone metabolism and the effect of androgens. Mol Cell Endocrinol 8:189-199
12. Harlow CR, Hillier SG, Hodges JK 1986 Androgen modulation of follicle-stimulating hormone-induced granulosa cell steroidogenesis in the primate ovary. Endocrinology 119:1403-1405
13. Daniel SAJ, Armstrong DT 1979 Enhancement of follicle-stimulating hormone-induced aromatase activity by androgens in cultured rat granulosa cells. Endocrinology 107:1027-1032
14. Erickson GF, Hsueh AJ 1978 Stimulation of aromatase activity by follicle-stimulating hormone in rat granulosa cells in vivo and in vitro. Endocrinology 102:1275-1282
15. Venturoli S, Paradisi R, Bagnoli A, Colombo FM, Ravaioli B, Vianello F, Manicini F, Gualerzi B, Porcu E, Seracchioli R 2002 Low-dose flutamide (125 mg/day) as maintenance therapy in the treatment of hirsutism. Horm Res 56:25-31
16. Ibanez L, Potau N, Marcos MV, de Zegher F 2000 Treatment of hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism in nonobese, adolescent girls: effect of flutamide. J Clin Endocrinol Metab 85:3251-3255
17. Vrbikova J, Hill M, Dvorakova K, Stanicka S, Vondra K, Starka L 2004 Flutamide suppresses adrenal steroidogenesis but has no effect on insulin resistance and secretion and lipid levels in overweight women with polycystic ovary syndrome. Gynecol Obstet Invest 58:36-41
18. Adashi EY, Hsueh AJW 1982 Estrogens augment the stimulation of ovarian aromatase activity by follicle-stimulating hormone in cultured rat granulosa cells. J Biol Chem 257:6077-6083
19. Knecht M, Darbon J-M, Ranta T, Baukal AJ, Catt KJ 1984 Estrogens enhance the adenosine 3′,5′-monophosphate-mediated induction of follicle-stimulating hormone and luteinizing hormone receptors in rat granulosa cells. Endocrinology 115:41-49
20. Ibanez L, Jaramillo A, Ferrer A, de Zegher F 2005 Absence of hepatotoxicity after long-term, low-dose flutamide in hyperandrogenic girls and young women. Hum Reprod 20:1833-1836
21. Schwimmer JB, Khorram O, Chiu V, Schwimmer WB 2005 Abnormal aminotransferase activity in women with polycystic ovary syndrome. Fertil Steril 83:494-497