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Volumn 67, Issue 9, 2006, Pages 1621-1627

Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite after oral and intravenous administration of pentoxifylline to healthy adult horses

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYHEXYLPENTOXIFYLLINE; DRUG METABOLITE; GENERIC DRUG; PENTOXIFYLLINE; UNCLASSIFIED DRUG;

EID: 33748744632     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.67.9.1621     Document Type: Article
Times cited : (37)

References (36)
  • 1
    • 0017120909 scopus 로고
    • Improvement of the flow properties of blood: A new therapeutical approach in occlusive arterial disease
    • Ehrly AM. Improvement of the flow properties of blood: a new therapeutical approach in occlusive arterial disease. Angiology 1976;27:188-196.
    • (1976) Angiology , vol.27 , pp. 188-196
    • Ehrly, A.M.1
  • 3
    • 0026685692 scopus 로고
    • Methylxanthine-induced inhibition of the antigen- and superantigen-specific activation of T and B lymphocytes
    • Rosenthal LA, Taub DD, Moors MA, et al. Methylxanthine-induced inhibition of the antigen- and superantigen-specific activation of T and B lymphocytes. Immunopharmacology 1992;24:203-217.
    • (1992) Immunopharmacology , vol.24 , pp. 203-217
    • Rosenthal, L.A.1    Taub, D.D.2    Moors, M.A.3
  • 4
    • 0025332660 scopus 로고
    • Mechanisms of tumor necrosis factor-alpha alteration of PMN adhesion and migration
    • Salyer JL, Bohnsack JF, Knape WA, et al. Mechanisms of tumor necrosis factor-alpha alteration of PMN adhesion and migration. Am J Pathol 1990;136:831-841.
    • (1990) Am J Pathol , vol.136 , pp. 831-841
    • Salyer, J.L.1    Bohnsack, J.F.2    Knape, W.A.3
  • 5
    • 0024514942 scopus 로고
    • Pentoxifylline inhibits normal human dermal fibroblast in vitro proliferation, collagen, glycosaminoglycan, and fibronectin production, and increases collagenase activity
    • Berman B, Duncan MR. Pentoxifylline inhibits normal human dermal fibroblast in vitro proliferation, collagen, glycosaminoglycan, and fibronectin production, and increases collagenase activity. J. Invest Dermatol 1989;92:605-610.
    • (1989) J Invest Dermatol , vol.92 , pp. 605-610
    • Berman, B.1    Duncan, M.R.2
  • 6
    • 0023189396 scopus 로고
    • Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy
    • Ward A, Clissold SP. Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs 1987;34:50-97.
    • (1987) Drugs , vol.34 , pp. 50-97
    • Ward, A.1    Clissold, S.P.2
  • 7
    • 0346729708 scopus 로고    scopus 로고
    • Pathogenesis and management of alcoholic hepatitis
    • Haber P, Warner R, Seth D, et al. Pathogenesis and management of alcoholic hepatitis. J Gastroenterol Hepatol 2003;18:1332-1334.
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 1332-1334
    • Haber, P.1    Warner, R.2    Seth, D.3
  • 8
    • 0022843878 scopus 로고
    • The role of haemorheological factors in the ageing brain: Long term therapy with pentoxifylline ('Trental' 400) in elderly patients with initial mental deterioration
    • Parnetti L, Ciuffetti G, Mercuri M, et al. The role of haemorheological factors in the ageing brain: long term therapy with pentoxifylline ('Trental' 400) in elderly patients with initial mental deterioration. Pharmatherapeutica 1986;4:617-627.
    • (1986) Pharmatherapeutica , vol.4 , pp. 617-627
    • Parnetti, L.1    Ciuffetti, G.2    Mercuri, M.3
  • 10
    • 0024343375 scopus 로고
    • The effect of pentoxifylline on early and late radiation injury following fractionated irradiation in C3H mice
    • Dion MW, Jussey DH, Osborne JW. The effect of pentoxifylline on early and late radiation injury following fractionated irradiation in C3H mice. Int J Radiat Oncol Biol Phys 1989;17:101-107.
    • (1989) Int J Radiat Oncol Biol Phys , vol.17 , pp. 101-107
    • Dion, M.W.1    Jussey, D.H.2    Osborne, J.W.3
  • 11
    • 0026752744 scopus 로고
    • Chronic leukocytoclastic vasculitis associated with polycythemia vera: Effective control with pentoxifylline
    • Wahba-Yahav AV. Chronic leukocytoclastic vasculitis associated with polycythemia vera: effective control with pentoxifylline. J Am Acad Dermatol 1992;26:1006-1007.
    • (1992) J Am Acad Dermatol , vol.26 , pp. 1006-1007
    • Wahba-Yahav, A.V.1
  • 12
    • 0031501222 scopus 로고    scopus 로고
    • Use of pentoxifylline in the treatment of allergic contact reactions to plants of the Commelinceae family in dogs
    • Marsella R, Kunkle GA, Lewis DT. Use of pentoxifylline in the treatment of allergic contact reactions to plants of the Commelinceae family in dogs. Vet Dermatol 1997;8:121-126.
    • (1997) Vet Dermatol , vol.8 , pp. 121-126
    • Marsella, R.1    Kunkle, G.A.2    Lewis, D.T.3
  • 13
    • 0037342091 scopus 로고    scopus 로고
    • A retrospective study regarding the treatment of lupoid onychodystrophy in 30 dogs and literature review
    • Mueller R, Rosychuk R, Jonas L. A retrospective study regarding the treatment of lupoid onychodystrophy in 30 dogs and literature review. J Am Anim Hosp Assoc 2003;39:139-150.
    • (2003) J Am Anim Hosp Assoc , vol.39 , pp. 139-150
    • Mueller, R.1    Rosychuk, R.2    Jonas, L.3
  • 14
    • 0031303656 scopus 로고    scopus 로고
    • Effects of pentoxifylline on motility and longevity of fresh and thawed dog spermatozoa
    • Koutsarova N, Todorov P, Koutsarov G. Effects of pentoxifylline on motility and longevity of fresh and thawed dog spermatozoa. J Reprod Fertil Suppl 1997;51:117-121.
    • (1997) J Reprod Fertil Suppl , vol.51 , pp. 117-121
    • Koutsarova, N.1    Todorov, P.2    Koutsarov, G.3
  • 15
    • 0028673907 scopus 로고
    • Pentoxifylline inhibits mediator synthesis in an equine in vitro whole blood model of endotoxemia
    • Barton MH, Moore JN. Pentoxifylline inhibits mediator synthesis in an equine in vitro whole blood model of endotoxemia. Circ Shock 1994;44:216-220.
    • (1994) Circ Shock , vol.44 , pp. 216-220
    • Barton, M.H.1    Moore, J.N.2
  • 16
    • 0030688917 scopus 로고    scopus 로고
    • The effects of pentoxifylline infusion on plasma 6-keto-prostaglandin Flα and ex vivo endotoxin-induced tumor necrosis factor activity in horses
    • Barton MH, Ferguson D, Davis PJ, et al. The effects of pentoxifylline infusion on plasma 6-keto-prostaglandin Flα and ex vivo endotoxin-induced tumor necrosis factor activity in horses. J Vet Pharmacol Ther 1997;20:487-492.
    • (1997) J Vet Pharmacol Ther , vol.20 , pp. 487-492
    • Barton, M.H.1    Ferguson, D.2    Davis, P.J.3
  • 17
    • 0025215045 scopus 로고
    • Pharmacokinetics of intravenous and oral pentoxifylline in healthy volunteers and in cirrhotic patients
    • Rames A, Poirier JM, LeCoz F, et al. Pharmacokinetics of intravenous and oral pentoxifylline in healthy volunteers and in cirrhotic patients. Clin Pharmacol Ther 1990;47:354-359.
    • (1990) Clin Pharmacol Ther , vol.47 , pp. 354-359
    • Rames, A.1    Poirier, J.M.2    LeCoz, F.3
  • 18
    • 0022355254 scopus 로고
    • Kinetics of intravenous and oral pentoxifylline in healthy subjects
    • Beermann B, Ings R, Mansby J, et al. Kinetics of intravenous and oral pentoxifylline in healthy subjects. Clin Pharmacol Ther 1985;37:25-28.
    • (1985) Clin Pharmacol Ther , vol.37 , pp. 25-28
    • Beermann, B.1    Ings, R.2    Mansby, J.3
  • 19
    • 0034076654 scopus 로고    scopus 로고
    • Pharmacokinetics of pentoxifylline in dogs after oral and intravenous administration
    • Marsella R, Nicklin C, Munson JW, et al. Pharmacokinetics of pentoxifylline in dogs after oral and intravenous administration. Am J Vet Res 2000;61:631-637.
    • (2000) Am J Vet Res , vol.61 , pp. 631-637
    • Marsella, R.1    Nicklin, C.2    Munson, J.W.3
  • 20
    • 79251510574 scopus 로고    scopus 로고
    • Dosing regimen and hematologic effects of pentoxifylline and its active metabolites in normal dogs
    • Rees CA, Boothe DM, Boeckh A, et al. Dosing regimen and hematologic effects of pentoxifylline and its active metabolites in normal dogs. Vet Ther 2003;4:188-196.
    • (2003) Vet Ther , vol.4 , pp. 188-196
    • Rees, C.A.1    Boothe, D.M.2    Boeckh, A.3
  • 21
    • 0027518736 scopus 로고
    • Pharmacokinetic disposition of intravenous and oral pentoxifylline in horses
    • Crisman MV, Wilcke JR, Correll LS, et al. Pharmacokinetic disposition of intravenous and oral pentoxifylline in horses. J Vet Pharmacol Ther 1993;16:23-31.
    • (1993) J Vet Pharmacol Ther , vol.16 , pp. 23-31
    • Crisman, M.V.1    Wilcke, J.R.2    Correll, L.S.3
  • 22
    • 0033128572 scopus 로고    scopus 로고
    • The effect of oral isoxsuprine and pentoxifylline on digital and laminar blood flow in healthy horses
    • Ingle-Fehr JE, Baxter GM. The effect of oral isoxsuprine and pentoxifylline on digital and laminar blood flow in healthy horses. Vet Surg 1999;28:154-160.
    • (1999) Vet Surg , vol.28 , pp. 154-160
    • Ingle-Fehr, J.E.1    Baxter, G.M.2
  • 23
    • 0036521395 scopus 로고    scopus 로고
    • Effects of pentoxifylline on pulmonary function and results of cytologic examination of bronchoalveolar lavage fluid in horses with recurrent airway obstruction
    • Leguillette R, Desevaux C, Lavoie JP. Effects of pentoxifylline on pulmonary function and results of cytologic examination of bronchoalveolar lavage fluid in horses with recurrent airway obstruction. Am J Vet Res 2002;63:459-463.
    • (2002) Am J Vet Res , vol.63 , pp. 459-463
    • Leguillette, R.1    Desevaux, C.2    Lavoie, J.P.3
  • 24
    • 0022657005 scopus 로고
    • Determination of pentoxifylline and a major metabolite, 3,7-dimethyl-1-(5-hydroxyhexyl)xanthine, by high-performance liquid chromatography
    • Luke DR, Rocci ML Jr. Determination of pentoxifylline and a major metabolite, 3,7-dimethyl-1-(5-hydroxyhexyl)xanthine, by high-performance liquid chromatography. J Chromatogr 1986;374:191-195.
    • (1986) J Chromatogr , vol.374 , pp. 191-195
    • Luke, D.R.1    Rocci Jr., M.L.2
  • 25
    • 0000722192 scopus 로고
    • Multiple dosing
    • In: 2nd ed. New York: Marcel Dekker
    • Gibaldi M, Perrier D. Multiple dosing. In: Pharmacokinetics. 2nd ed. New York: Marcel Dekker, 1982;113-144.
    • (1982) Pharmacokinetics , pp. 113-144
    • Gibaldi, M.1    Perrier, D.2
  • 26
    • 0021989424 scopus 로고
    • Estimation of variance for harmonic mean half-lives
    • Lam F, Hung C, Perrier D. Estimation of variance for harmonic mean half-lives. J Pharm. Sci 1985;74:229-231.
    • (1985) J Pharm Sci , vol.74 , pp. 229-231
    • Lam, F.1    Hung, C.2    Perrier, D.3
  • 27
    • 33748744056 scopus 로고    scopus 로고
    • Monographs
    • In: O'Neil MJ, Smith A, Heckelman PE, et al, eds. 13th ed. Whitehouse Station, NJ: Merck & Co Inc
    • O'Neil MJ, Smith A, Heckelman PE, et al. Monographs. In: O'Neil MJ, Smith A, Heckelman PE, et al, eds. The Merck index. 13th ed. Whitehouse Station, NJ: Merck & Co Inc, 2001; 1280.
    • (2001) The Merck Index , pp. 1280
    • O'Neil, M.J.1    Smith, A.2    Heckelman, P.E.3
  • 28
    • 6844241939 scopus 로고    scopus 로고
    • Circadian variations in the pharmacokinetics of pentoxifylline in man
    • Srinivasu P, Rao BR, Rao YM, et al. Circadian variations in the pharmacokinetics of pentoxifylline in man. J Pharm Pharmacol 1998;50:71-74.
    • (1998) J Pharm Pharmacol , vol.50 , pp. 71-74
    • Srinivasu, P.1    Rao, B.R.2    Rao, Y.M.3
  • 29
    • 0023217643 scopus 로고
    • Studies on theophylline metabolism: Autoinduction and inhibition by antipyrine
    • Denlinger CL, Stryker KK, Slusher LB, et al. Studies on theophylline metabolism: autoinduction and inhibition by antipyrine. Clin Pharmacol Ther 1987;41:522-530.
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 522-530
    • Denlinger, C.L.1    Stryker, K.K.2    Slusher, L.B.3
  • 30
    • 0015367204 scopus 로고
    • Structure of the excretion products of 3,7-dimethyl-1-(5-oso-hemyl)-xanthine (BL 191) in man
    • Hinze HJ, Bedessem G, Soder A. Structure of the excretion products of 3,7-dimethyl-1-(5-oso-hemyl)-xanthine (BL 191) in man. Arzneimittelforschung 1972;22:1144-1151.
    • (1972) Arzneimittelforschung , vol.22 , pp. 1144-1151
    • Hinze, H.J.1    Bedessem, G.2    Soder, A.3
  • 31
    • 0024518840 scopus 로고
    • Urinary excretion of pentoxifylline and its metabolites by standardbred mares
    • Kwong EC, Chen FC, Young LM. Urinary excretion of pentoxifylline and its metabolites by standardbred mares. Can J Vet Res 1989;53:147-153.
    • (1989) Can J Vet Res , vol.53 , pp. 147-153
    • Kwong, E.C.1    Chen, F.C.2    Young, L.M.3
  • 32
    • 0021253301 scopus 로고
    • Pharmacology of pentoxifylline, a hemorheologic agent for the treatment of intermittent claudication
    • Aviado DM, Dettelbach HR. Pharmacology of pentoxifylline, a hemorheologic agent for the treatment of intermittent claudication. Angiology 1984;35:407-417.
    • (1984) Angiology , vol.35 , pp. 407-417
    • Aviado, D.M.1    Dettelbach, H.R.2
  • 33
    • 0004364841 scopus 로고
    • Analytical and toxicological data
    • In: Moffat AC, Jackson JV, Moss MS, eds. 2nd ed. London: The Pharmacological Press
    • Moffat AC, Jackson JV, Moss MS, et al. Analytical and toxicological data. In: Moffat AC, Jackson JV, Moss MS, eds. Clarke's isolation and identification of drugs. 2nd ed. London: The Pharmacological Press, 1986;838.
    • (1986) Clarke's Isolation and Identification of Drugs , pp. 838
    • Moffat, A.C.1    Jackson, J.V.2    Moss, M.S.3
  • 35
    • 0035403893 scopus 로고    scopus 로고
    • Intravenous pentoxifylline does not enhance the pulmonary haemodynamic efficacy of frusemide in strenuously exercising Thoroughbred horses
    • Manohar M, Goetz TE, Rothenbaum P, et al. Intravenous pentoxifylline does not enhance the pulmonary haemodynamic efficacy of frusemide in strenuously exercising Thoroughbred horses. Equine Vet J 2001;33:354-359.
    • (2001) Equine Vet J , vol.33 , pp. 354-359
    • Manohar, M.1    Goetz, T.E.2    Rothenbaum, P.3
  • 36
    • 0030669648 scopus 로고    scopus 로고
    • Effects of pentoxilylline infusion on response of horses to in vivo challenge exposure with endotoxin
    • Barton MH, Moore JN, Norton N. Effects of pentoxilylline infusion on response of horses to in vivo challenge exposure with endotoxin. Am J Vet Res 1997;58:1300-1307.
    • (1997) Am J Vet Res , vol.58 , pp. 1300-1307
    • Barton, M.H.1    Moore, J.N.2    Norton, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.