Inhibition of endogenous reverse transcription of human and nonhuman primate lentiviruses: Potential for development of lentivirucides

Virology

Volumn 353, Issue 2, 2006, Pages 482-490

  Argyris, Elias G ^a   Dornadula, Geethanjali ^a   Nunnari, Giuseppe ^a   Acheampong, Edward ^a   Zhang, Chune ^a   Mehlman, Ketti ^a   Pomerantz, Roger J ^a   Zhang, Hui ^a  

^a Center for Human Virology   (United States)

Author keywords

HIV 1; NERT; NNRTI; NRTI; RT; SIV; Virucide

Indexed keywords

ANTIRETROVIRUS AGENT; ANTIVIRUS AGENT; NEVIRAPINE; NUCLEOSIDE; ZIDOVUDINE 5' TRIPHOSPHATE;

ANALYSIS; ARTICLE; CELL CULTURE; CELL FREE SYSTEM; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG POTENCY; DRUG TARGETING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; INHIBITION KINETICS; LENTIVIRINAE; PHYSIOLOGY; PRIMATE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION; SEXUAL TRANSMISSION; T LYMPHOCYTE; VIRION; VIRUS INACTIVATION; VIRUS INFECTIVITY;

ANTIVIRAL AGENTS; CELLS, CULTURED; DISEASE TRANSMISSION, HORIZONTAL; HIV-1; HUMANS; LENTIVIRUS INFECTIONS; NEVIRAPINE; REVERSE TRANSCRIPTASE INHIBITORS; SIMIAN IMMUNODEFICIENCY VIRUS; T-LYMPHOCYTES; THYMINE NUCLEOTIDES; TRANSCRIPTION, GENETIC; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS 1; PRIMATES; SIMIAN IMMUNODEFICIENCY VIRUS; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

EID: 33748705343     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2006.06.014     Document Type: Article

References (37)

1. Argyris E.G., Acheampong E., Nunnari G., Mukhtar M., Williams K.J., and Pomerantz R.J. Human immunodeficiency virus type 1 enters primary human brain microvascular endothelial cells by a mechanism involving cell surface proteoglycans independent of lipid rafts. J. Virol. 77 (2003) 12140-12151
2. Baltimore D. Viral RNA-dependent DNA polymerase. Nature 226 (1970) 1209-1211
3. Balzarini J., DeClercq E., and Uberla K. SIV/HIV-1 hybrid virus expressing the reverse transcriptase gene of HIV-1 remains sensitive to HIV-1-specific reverse transcriptase inhibitors after passage in rhesus macaques. J. AIDS 15 (1997) 1-4
4. Balzarini J., Naesens L., Verbeken E., Laga M., Van Damme L., Parniak M., Van Mellaert L., Anne J., and De Clercq E. Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent. AIDS 12 (1998) 1129-1138
5. Boone L.R., and Skalka A.M. Viral DNA synthesized in vitro by avian retrovirus particles permeabilized with mellittin. J. Virol. 37 (1981) 109-116
6. Boone L.R., and Skalka A.M. Viral DNA synthesized in vitro by avian retrovirus particles permeabilized with melittin. J. Virol. 37 (1981) 117-126
7. Borroto-Esoda K., and Boone L.R. Equine infectious anemia virus and HIV DNA synthesis in vitro: characterization of the endogenous reverse transcriptase reaction. J. Virol. 65 (1991) 1952-1959
8. Chernomordik L., Chanturiya A.N., Suss-Toby E., Nora E., and Zimmerberg J. An amphipathic peptide from the C-terminal region of the human immunodeficiency virus envelope glycoprotein causes pore formation in membranes. J. Virol. 68 (1994) 7115-7123
9. Coffin J.M. Retroviridae and their replication. In: Fields B.N. (Ed) (1990), Virology. Raven Press Ltd, New York 1437-1499
10. Collman R., Hassan N.F., Walker R., Godfrey B., Cutilli J., Hastings J.C., Friedman H., Douglas S.D., and Nathanson N. Infection of monocyte-derived macrophages with human immunodeficiency virus type 1 (HIV-1). Monocyte-tropic and lymphocyte-tropic strains of HIV-1 show distinctive patterns of replication in a panel of cell types. J. Exp. Med. 170 (1989) 1149-1163
11. Debyser Z., Vandamme A.M., Pauwels R., Baba M., Desmyter J., and DeClercq E. Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2,3-dideoxynucleoside 5-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thione, and 1-[(2-hydroxyethoxy) methyl]-6-(phenylthio) thymine derivatives. J. Biol. Chem. 267 (1992) 11769-11776
12. Dornadula G., Zhang H., Bagasra O., and Pomerantz R.J. Natural endogenous reverse transcription of simian immunodeficiency virus. Virology 227 (1997) 260-267
13. Dornadula G., Zhang H., Shetty S., and Pomerantz R.J. HIV-1 virions produced from replicating peripheral blood lymphocytes are more infectious than those from nonproliferating macrophages due to higher levels of intravirion reverse transcripts: Implications for pathogenesis and transmission. Virology 253 (1999) 10-16
14. Fauci A.S. Multifactorial nature of HIV disease: implications for therapy. Science 262 (1993) 1011-1018
15. Fichorova R.N., Zhou F., Ratnam V., Atanassova V., Jiang S., Strick N., and Neurath A.R. Anti-human immunodeficiency virus type 1 microbicide cellulose acetate 1,2-benzenedicarboxylate in a human in vitro model of vaginal inflammation. Antimicrob. Agents Chemother. 49 (2005) 323-335
16. Garapin A., McDonnell J.P., Levinson W., Quintrell N., Fanshier L., and Bishop J.M. Deoxyribonucleic acid polymerases associated with Rous sarcoma virus and avian myeloblastosis: properties of the enzyme and its product. J. Virol. 6 (1970) 589-598
17. Gilboa E., Mitra S.W., Goff S., and Baltimore D. A detailed model of reverse transcription and tests of crucial aspects. Cell 18 (1979) 93-100
18. Letvin N.L., Li J., Halloran M., Cranage M.P., Rud E.W., and Sodroski J. Prior infection with a nonpathogenic chimeric simian-human immunodeficiency virus does not efficiently protect macaques against challenge with simian immunodeficiency virus. J. Virol. 69 (1995) 4569-4571
19. Miller M.A., Garry R.F., Jaynes J.M., and Montelaro R.C. A structural correlation between lentivirus transmembrane proteins and natural cytolytic peptides. AIDS Res. Hum. Retroviruses 7 (1991) 511-519
20. Miller M.A., Cloyd M.W., Liebmann J., Rinaldo Jr. C.R., Islam K.R., Wang S.Z., Mietzner T.A., and Montelaro R.C. Alterations in cell membrane permeability by the lentivirus lytic peptide (LLP-1) of HIV-1 transmembrane protein. Virology 196 (1993) 89-100
21. Miller C.J., Marthas M., Torten J., Alexander N.J., Moore J.P., Doncel G.F., and Hendrickx A.G. Intravaginal inoculation of rhesus macaques with cell-free simian immunodeficiency virus results in persistent or transient viremia. J. Virol. 68 (1994) 6391-6400
22. Miller C.J., Marthas M., Greenier J., Lu D., Dailey P.J., and Lu Y. In vivo replication capacity rather than in vitro macrophage tropism predicts efficiency of vaginal transmission of simian immunodeficiency virus or simian/human immunodeficiency virus in rhesus macaques. J. Virol. 72 (1998) 3248-3258
23. Mori K., Yasutomi Y., Sawada S., Villinger F., Sugama K., Rosenwith B., Heeney J.L., Uberla K., Yamazaki S., Ansari A.A., and Rubsamen-Waigmann H. Suppression of acute viremia by short-term post exposure prophylaxis of simian/human immunodeficiency virus SHIV/RT-infected monkeys with a novel reverse tanscriptase inhibitor (GW420867) allows for development of potent antiviral immune responses resulting in efficient containment of infection. J. Virol. 74 (2000) 5747-5753
24. Poiesz B.J., Ruscetti F.W., Gazdar A.F., Bunn P.A., Minna J.D., and Gallo R.C. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. U. S. A. 77 (1980) 7415-7419
25. Rosenwirth B., Bogers W.M., Nieuwenhuis I.G., Haaft P.T., Niphuis H., Kuhn E.M., Bischofberger N., Erfle V., Sutter G., Berglund P., Liljestrom P., Uberla K., and Heeney J.L. An anti-HIV strategy combining chemotherapy and therapeutic vaccination. J. Med. Primatol. 28 (1999) 195-205
26. Temin H.M., and Mizutani S. RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature 226 (1970) 1211-1213
27. Uberla K., Stahl-Hennig C., Bottiger D., Matz-Rensing K., Kaup F.J., Li J., Haseltine W.A., Fleckenstein B., Hunsmann G., Oberg B., et al. Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors. Proc. Natl. Acad. Sci. U. S. A 92 (1995) 8210-8214
28. van Damme L., and Rosenberg Z.F. Microbicides and barrier methods in HIV prevention. AIDS 13 (1999) S85-S92
29. Yong W.H., Wyman S., and Levy J.A. Optimal conditions for synthesizing complementary DNA in the HIV-1 endogenous reverse transcriptase reaction. AIDS 4 (1990) 199-206
30. Zhang H., Zhang Y., Spicer T.P., Abbott L.Z., Abbott M., and Poiesz B.J. Reverse transcription takes place within extracellular HIV-1 virions: potential biological significance. AIDS Res. Hum. Retroviruses 9 (1993) 1287-1296
31. Zhang H., Bagasra O., Niikura M., Poiesz B.J., and Pomerantz R.J. Intravirion reverse transcripts in the peripheral blood plasma of human immunodeficiency virus type 1 infected individuals. J. Virol. 68 (1994) 7591-7597
32. Zhang H., Dornadula G., Wu Y., Havlir D., Richman D.D., and Pomerantz R.J. Kinetic analysis of intravirion reverse transcription in the blood plasma of human immunodeficiency virus type 1-infected individuals: Direct assessment of resistance to reverse transcriptase inhibitors in vivo. J. Virol. 70 (1996) 628-634
33. Zhang H., Dornadula G., and Pomerantz R.J. Endogenous reverse transcription of human immunodeficiency virus type 1 in physiological microenvironinents: an important stage for viral infection of non-dividing cells. J. Virol. 70 (1996) 2809-2824
34. Zhang H., Dornadula G., Alur P., Laughlin M.A., and Pomerantz R.J. Amphipathic domains in the C terminus of the transmembrane protein (gp4l) permeabilize HIV-1 virions: a molecular mechanism underlying natural endogenous reverse transcription. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 12519-12524
35. Zhang H., Dornadula G., and Pomerantz R.J. Natural endogenous reverse transcription of HIV type 1. AIDS Res. Hum. Retroviruses, Suppl. 1 (1998) 93-95
36. Zhang H., Pomerantz R.J., Dornadula G., and Sun Y. HIV-1 Vif protein is an integral component of an mRNP complex of viral RNA and could be involved in the viral RNA folding and packaging process. J. Virol. 74 (2000) 8252-8261
37. Zhu T., Mo H., Wang N., Nam D.S., Cao Y., Koup R.A., and Ho D.D. Genotypic and phenotypic characterization of HIV-1 patients with primary infection. Science 261 (1993) 1179-1181