메뉴 건너뛰기




Volumn 36, Issue 9, 2006, Pages 807-823

Disposition and metabolism of almotriptan in rats, dogs and monkeys

Author keywords

Almotriptan; Deamination; Disposition; N oxidation; Pyrrolidine ring oxidation

Indexed keywords

4 AMINOBUTYRIC ACID; ALMOTRIPTAN; CARBON 14; DRUG METABOLITE; INDOLEACETIC ACID;

EID: 33748695059     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250600802508     Document Type: Article
Times cited : (9)

References (25)
  • 3
    • 0035741491 scopus 로고    scopus 로고
    • Vascular effects of the new anti-migraine agent almotriptan on human cranial and peripheral arteries
    • Bou J, Gras J, Cortijo J, Morcillo EJ, Llenas J, Palacios JM. 2001. Vascular effects of the new anti-migraine agent almotriptan on human cranial and peripheral arteries. Cephalgia 21:804-812.
    • (2001) Cephalgia , vol.21 , pp. 804-812
    • Bou, J.1    Gras, J.2    Cortijo, J.3    Morcillo, E.J.4    Llenas, J.5    Palacios, J.M.6
  • 5
    • 0035128857 scopus 로고    scopus 로고
    • Long-term efficacy and safety of oral almotriptan: Interim analysis of a 1-year open study
    • Cabarrocas X, Esbri R, Peris F, Ferrer P. 2001. Long-term efficacy and safety of oral almotriptan: Interim analysis of a 1-year open study. Headache 41:57-62.
    • (2001) Headache , vol.41 , pp. 57-62
    • Cabarrocas, X.1    Esbri, R.2    Peris, F.3    Ferrer, P.4
  • 6
    • 0020161757 scopus 로고
    • Manual of symbols, equations and definitions in Pharmacokinetics
    • Committee for Pharmacokinetic Nomenclature of the American College of Clinical Pharmacology. 1982. Manual of symbols, equations and definitions in Pharmacokinetics. Journal of Clinical Pharmacology 22:1S-23S.
    • (1982) Journal of Clinical Pharmacology , vol.22
  • 7
    • 0028353855 scopus 로고
    • Characterization of the enzyme responsible for the metabolism of sumatriptan in human liver
    • Dixon CM, Park GR, Tarbit MH. 1994. Characterization of the enzyme responsible for the metabolism of sumatriptan in human liver. Biochemical and Pharmacology 47:1253-1257.
    • (1994) Biochemical and Pharmacology , vol.47 , pp. 1253-1257
    • Dixon, C.M.1    Park, G.R.2    Tarbit, M.H.3
  • 9
    • 0035016376 scopus 로고    scopus 로고
    • Oral almotriptan in the treatment of migraine: Safety and tolerability
    • Dodick DW. 2001. Oral almotriptan in the treatment of migraine: Safety and tolerability. Headache 41:449-455.
    • (2001) Headache , vol.41 , pp. 449-455
    • Dodick, D.W.1
  • 10
    • 2942519284 scopus 로고    scopus 로고
    • Triptans and CNS side-effects: Pharmacokinetic and metabolic mechanisms
    • Dodick DW, Martin V. 2004. Triptans and CNS side-effects: Pharmacokinetic and metabolic mechanisms. Cephalalgia 24:417-424.
    • (2004) Cephalalgia , vol.24 , pp. 417-424
    • Dodick, D.W.1    Martin, V.2
  • 12
    • 85005302491 scopus 로고
    • 5-HT1 receptors in migraine pathophysiology and treatment
    • Ferrari MD, Saxena PR. 1995. 5-HT1 receptors in migraine pathophysiology and treatment. European Journal of Neurology 2:5-21.
    • (1995) European Journal of Neurology , vol.2 , pp. 5-21
    • Ferrari, M.D.1    Saxena, P.R.2
  • 14
    • 0034694789 scopus 로고    scopus 로고
    • Cardiovascular safety profile of almotriptan, a new indolic derivative for the treatment of migraine
    • Gras J, Cardelus I, Llenas J, Palacios JM. 2000b. Cardiovascular safety profile of almotriptan, a new indolic derivative for the treatment of migraine. European Journal of Pharmacology 410:53-59.
    • (2000) European Journal of Pharmacology , vol.410 , pp. 53-59
    • Gras, J.1    Cardelus, I.2    Llenas, J.3    Palacios, J.M.4
  • 15
    • 18744410063 scopus 로고    scopus 로고
    • Absolute bioavailability, pharmacokinetics, and urinary excretion of the novel antimigraine agent almotriptan in healthy male volunteers
    • Jansat JM, Costa J, Salva P, Fernandez FJ, Martinez-Tobed A. 2002. Absolute bioavailability, pharmacokinetics, and urinary excretion of the novel antimigraine agent almotriptan in healthy male volunteers. Journal of Clinical Pharmacology 42:1303-1310.
    • (2002) Journal of Clinical Pharmacology , vol.42 , pp. 1303-1310
    • Jansat, J.M.1    Costa, J.2    Salva, P.3    Fernandez, F.J.4    Martinez-Tobed, A.5
  • 18
    • 0034453789 scopus 로고    scopus 로고
    • Consistent efficacy and tolerability of almotriptan in the acute treatment of multiple migraine attacks: Results of a large, randomized, double-blind, placebo-controlled study
    • Pascual J, Falk RM, Piessens F, Prusinski A, Docekal P, Robert M, Ferrer P, Luria X, Segarra R, Zayas JM. 2000. Consistent efficacy and tolerability of almotriptan in the acute treatment of multiple migraine attacks: Results of a large, randomized, double-blind, placebo-controlled study. Cephalgia 20:588-596.
    • (2000) Cephalgia , vol.20 , pp. 588-596
    • Pascual, J.1    Falk, R.M.2    Piessens, F.3    Prusinski, A.4    Docekal, P.5    Robert, M.6    Ferrer, P.7    Luria, X.8    Segarra, R.9    Zayas, J.M.10
  • 19
    • 0031803892 scopus 로고    scopus 로고
    • Sumatriptan. An updated review of its use in migraine
    • Perry CM, Markham A. 1998. Sumatriptan. An updated review of its use in migraine. Drugs 55:889-922.
    • (1998) Drugs , vol.55 , pp. 889-922
    • Perry, C.M.1    Markham, A.2
  • 20
    • 0037382092 scopus 로고    scopus 로고
    • Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan
    • Salva M, Jansat JM, Martinez-Tobed A, Palacios P. 2003. Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metabolism and Disposition 31:404-411.
    • (2003) Drug Metabolism and Disposition , vol.31 , pp. 404-411
    • Salva, M.1    Jansat, J.M.2    Martinez-Tobed, A.3    Palacios, P.4
  • 24
    • 0032878034 scopus 로고    scopus 로고
    • Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan
    • Wild MJ, McKillop D, Butters CJ. 1999. Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan. Xenobiotica 29:847-885.
    • (1999) Xenobiotica , vol.29 , pp. 847-885
    • Wild, M.J.1    McKillop, D.2    Butters, C.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.