GLC756 decreases TNF-α via an alpha2 and beta2 adrenoceptor related mechanism

Experimental Eye Research

Volumn 83, Issue 5, 2006, Pages 1246-1251

  Laengle, Ulrich W ^a   Trendelenburg, Anne U ^a   Markstein, Rudolf ^a   Nogues, Vicente ^a   Provencher Bollinger, Anne ^b   Roman, Danielle ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NONE

Author keywords

alpha2 adrenoceptor; anti glaucoma; beta2 adrenoceptor; dopamine D1 antagonist; dopamine D2 agonist; GLC756; TNF

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 3 [[4 (4 CHLOROPHENYL) 1 PIPERAZINYL]METHYL] 1H PYRROLO[2,3 B]PYRIDINE; 3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ANTIGLAUCOMA AGENT; BETA 2 ADRENORECEPTOR ANTAGONIST; BLOCKING AGENT; DOPAMINE RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; GLC 756; HALOPERIDOL; KETANSERIN; MEDETOMIDINE; METITEPINE; PD 168077; PHENYLEPHRINE; PRAZOSIN; QUINAGOLIDE; SALBUTAMOL; SEROTONIN 1A RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG; XAMOTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; DRUG BINDING SITE; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; RAT STRAIN; SALMONELLA TYPHIMURIUM; STATISTICAL SIGNIFICANCE; UVEITIS;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC BETA-2 RECEPTOR ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; DISEASE MODELS, ANIMAL; LIPOPOLYSACCHARIDES; MEDETOMIDINE; PROPANOLAMINES; QUINOLINES; RATS; RATS, INBRED LEW; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, ADRENERGIC; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; SEROTONIN 5-HT1 RECEPTOR ANTAGONISTS; SEROTONIN AGONISTS; SEROTONIN RECEPTOR AGONISTS; TUMOR NECROSIS FACTOR-ALPHA; UVEITIS;

EID: 33748681920     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2006.07.001     Document Type: Article

References (31)

1. Abraham E., Kaneko D.J., and Shenkar R. Effects of endogenous and exogenous catecholamines on LPS-induced neutrophil trafficking and activation. Am. J. Physiol. Lung Cell Mol. Physiol. 276 (1999) 1-8
2. Addicks E.M., Quigley H.A., Greene W.R., and Robin A.L. Histologic characteristics of filtering blebs in glaucomatous eyes. Arch. Ophthalmol. 101 (1983) 795-798
3. Ariturk N., Oge I., Baris S., Erkan D., Sullu Y., and Koc F. The effects of antiglaucomatous agents on conjunctiva used for various durations. Int. Ophthalmol. 20 (1997) 57-62
4. Boy C., Klimke A., Holschbach M., Herzog H., Muhlensiepen H., Rota Kops E., Sonnenberg F., Gaebel W., Stocklin G., Markstein R., and Muller-Gartner H.W. Imaging dopamine D4 receptors in the living primate brain: a positron emission tomography study using the novel D1/D4 antagonist [11C]SDZ GLC 756. Synapse 30 (1998) 341-350
5. Broadway D.C., Grierson I., O'Brien C., and Hitchings R.A. Adverse effects of topical antiglaucoma medication. I. The conjunctival cell profile. Arch. Ophthalmol. 112 (1994) 1437-1445
6. Chiou G.C., and Chen Y.J. Effects of dopamine agonist, bromocriptine, and some dopamine antagonists on ocular blood flow. J. Ocul. Pharmacol. 8 (1992) 285-294
7. Cloez-Tayarani I., Petit-Bertron A.F., Venters H.D., and Cavaillon J.M. Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors. Int. Immunol. 15 (2003) 233-240
8. Durum S.K., and Oppenheim J.J. In: Paul W.E. (Ed). Fundamental immunology (1989), Ravens Press, New York 639-661
9. Feghali C.A., and Wright T.M. Cytokines in acute and chronic inflammation. Frontiers Biosci. 2 (1997) 12-16
10. Flaxel J.T., and Swan K.C. Limbal wound healing after cataract extraction. Arch. Ophthalmol. 81 (1969) 653-659
11. Fong Y., and Lowry S.F. Tumor necrosis factor in the pathophysiology of infection and sepsis. Clin. Immunol. Immuopathol. 55 (1990) 157-170
12. Hasko G., Elenkov I.J., Kvetan V., and Vizi E.S. Differential effect of selective block of alpha 2-adrenoreceptors on plasma levels of tumour necrosis factor-alpha, interleukin-6 and corticosterone induced by bacterial lipopolysaccharide in mice. J. Endocrinol. 144 (1995) 457-462
13. Hasko G., Szabo C., Merkel K., Bencsics A., Zingarelli B., Kvetan V., and Vizi E.S. Modulation of lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by dopamine receptor agonists and antagonists in mice. Immunol. Lett. 49 (1996) 143-147
14. Izeboud C.A., Mocking J.A., Monshouwer M., van Miert A.S., and Witkamp R.F. Participation of beta-adrenergic receptors on macrophages in modulation of LPS-induced cytokine release. J. Recept. Signal. Transduct. Res. 19 (1999) 191-202
15. 1 antagonist, and timolol on endotoxin-induced TNF-alpha release in serum of rats. Eur. J. Ophthalmol. 16 (2006) 401-406
16. Markstein R., Gull P., Rudeberg C., Urwyler S., Jaton A.L., Kalkman H.O., Dixon A.K., and Hoyer D. SDZ GLC 756, a novel octahydrobenzo[g]quinoline derivative exerts opposing effects on dopamine D1 and D2 receptors. J. Neural. Transm. 103 (1996) 17-30
17. Masuda A., Yoshikai Y., Aiba K., and Matsuguchi T. Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathways. J. Immunol. 169 (2002) 3801-3810
18. Maumenee A.E. External filtering operations for glaucoma: the mechanism of function and failure. Trans. Am. Ophthalmol. Soc. 58 (1960) 319-328
19. Miller M.H., Grierson I., Unger W.I., and Hitchings R.A. Wound healing in an animal model of glaucoma fistulizing surgery in the rabbit. Ophthalmic Surg. 20 (1989) 350-357
20. Pisella P.J., Debbasch C., Hamard P., Creuzot-Garcher C., Rat P., Brignole F., and Baudouin C. Conjunctival proinflammatory and proapoptotic effects of latanoprost and preserved and unpreserved timolol: an ex vivo and in vitro study. Invest. Ophthalmol. Vis. Sci. 45 (2004) 1360-1368
21. Pruente C., and Flammer J. The novel dopamine D1 antagonist and D2 agonist, SDZ GLC 756, lowers intraocular pressure in healthy human volunteers and in patients with glaucoma. Ophthalmology 102 (1995) 1291-1297
22. Prünte C., Flammer J., Markstein R., and Rudin M. Quantification of optic nerve blood flow using MR-imaging. Invest. Ophthalmol. Vis. Sci. 36 (1995) 247-251
23. Pruente C., Nuttli I., and Markstein R. Topical SDZ GLC-756, a novel dopamine D-1 antagonist and D-2 agonist, lowers intraocular pressure in conscious rabbits. Jpn. J. Ophthalmol. 40 (1996) 167-173
24. Quigley H.A., Nickells R.W., Kerrigan L.A., Pease M.E., Thibault D.J., and Zack D.J. Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest. Ophthalmol. Vis. Sci. 36 (1995) 774-786
25. Ruiz-Moreno J.M., Misiuk-Hojlo M., Thillaye B., and de Kozak Y. Suppression of experimental autoimmune uveoretinitis by prazosin, an alpha 1-adrenergic receptor antagonist. Curr. Eye Res. 11 (1992) 135-140
26. Sherwood M.B., Grierson I., Millar L., and Hitchings R.A. Long-term morphololgic effects of antiglaucoma drugs on the conjunctiva and Tenon's capsule in glaucomatous patients. Ophthalmology 96 (1989) 327-335
27. Spengler R.N., Allen R.M., Remick D.G., Strieter R.M., and Kunkel S.L. Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor. J. Immunol. 145 (1990) 1430-1434
28. Spengler R.N., Chensue S.W., Giacherio D.A., Blenk N., and Kunkel S.L. Endogenous norepinephrine regulates tumor necrosis factor-alpha production from macrophages in vitro. J. Immunol. 152 (1994) 3024-3031
29. Tezel G., and Wax M.B. Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells. J. Neurosci. 20 (2000) 8693-8700
30. Yan X., Tezel G., Wax M.B., and Edward D.P. Matrix metalloproteinases and tumor necrosis factor alpha in glaucomatous optic nerve head. Arch. Ophthalmol. 118 (2000) 666-673
31. Yoshimura T., Kurita C., Nagao T., Usami E., Nakao T., Watanabe S., Kobayashi J., Yamazaki F., Tanaka H., Inagaki N., and Nagai H. Inhibition of tumor necrosis factor-alpha and interleukin-1-beta production by beta-adrenoceptor agonists from lipopolysaccharide-stimulated human peripheral blood mononuclear cells. Pharmacology 54 (1997) 144-152