Pulmonary embolism: Accuracy and safety of a negative CT pulmonary angiogram and value of a negative D-dimer assay to exclude CT pulmonary angiogram-detectable pulmonary embolism

Australasian Radiology

Volumn 50, Issue 5, 2006, Pages 424-428

  Subramaniam, R M ^a,b,c   Chou, T ^b   Swarbrick, M ^b   Karalus, N ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c MAYO CLINIC   (United States)

Author keywords

Computed tomography pulmonary angiogram; D dimer; Pulmonary embolism

Indexed keywords

D DIMER;

ADULT; AGED; ANTICOAGULATION; ASSAY; CONFERENCE PAPER; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FEMALE; FOLLOW UP; HUMAN; INTERMETHOD COMPARISON; LUNG ANGIOGRAPHY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RADIATION SAFETY; SPIRAL COMPUTER ASSISTED TOMOGRAPHY; VENOUS THROMBOEMBOLISM;

ADULT; AGED; AGED, 80 AND OVER; COHORT STUDIES; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PULMONARY ARTERY; PULMONARY EMBOLISM; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; TOMOGRAPHY, SPIRAL COMPUTED;

EID: 33748671581     PISSN: 00048461     EISSN: 14401673     Source Type: Journal    
DOI: 10.1111/j.1440-1673.2006.01595.x     Document Type: Conference Paper

References (43)

1. Stein P, Huang H, Afzal A, Noor H. Incidence of acute pulmonary embolism among patients in a general hospital. Chest 1999; 116: 909-13.
2. Dalen J, Alpert J. Natural history of pulmonary embolism. Prog Cardiovasc Dis 1975; 17: 259-70.
3. Dismuke S, Wagner E. Pulmonary embolism as a cause of death. The changing mortality in hospitalized patients. JAMA 1986; 255: 2039-42.
4. Horlander K, Mannino D, Leeper K. Pulmonary embolism mortality in United States, 1979-1998: an analysis using multiple-cause mortality data. Arch Intern Med 2003; 163: 1711-17.
5. Carson J, Kelly M, Duff A et al. The clinical course of pulmonary embolism: one year follow up of PIOPED patients. N Engl J Med 1992; 326: 1240-45.
6. NIH Consensus Development. Prevention of venous thrombosis and pulmonary embolism. JAMA 1986; 256: 744-9.
7. Goodman L, Curtin J, Mewissen M et al. Detection of pulmonary embolism in patients with unresolved clinical and scintigraphic diagnosis: helical CT versus angiography. AJR 1995; 164: 1369-74.
8. Perrier A, Howarth N, Didier D et al. Performance of helical computed tomography in unselected outpatients with suspected pulmonary embolism. Ann Intern Med 2001; 135: 88-97.
9. Quiroz R, Kucher N, Zou KH et al. Clinical validity of a negative computed tomography scan in patients with suspected pulmonary embolism: a systematic review. JAMA 2005; 293: 2012-17.
10. Rathbun S, Raskob G, Whitsett T. Sensitivity and specificity of helical computed tomography in the diagnosis of pulmonary embolism: a systematic review. Ann Intern Med 2000; 32: 227-32.
11. de Monye W, Pattynama P. Contrast enhanced spiral computed tomography of the pulmonary arteries: an overview. Semin Thromb Hemost 2001; 27: 33-9.
12. Goldhaber S, Simons G, Elliot C et al. Quantitative plasma D dimer levels among patients undergoing pulmonary angiography for suspected pulmonary embolism. JAMA 1993; 270: 2819-22.
13. Guidelines on diagnosis and management of acute pulmonary embolism. European Society of Cardiology. Eur Heart J 2000; 21: 1301-36.
14. Ginsberg J, Wells P, Kearon C et al. Sensitivity and specificity of a rapid whole blood assay for D dimer in the diagnosis of pulmonary embolism. Ann Intern Med 1998; 129: 1006-11.
15. Wells P, Anderson D, Rodger M et al. Derivation of a single clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with simpliRED d-dimer. Thromb Haemost 2000; 83: 416-20.
16. Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). The PIOPED Investigators. JAMA 1990; 263: 2753-9.
17. Cini M, Legnani C, Cavallaroni K, Bettini F, Palareti G. A new rapid bedside assay for D-dimer measurement (Simplify D-dimer) in the diagnostic work-up for deep vein thrombosis. J Thromb Haemost 2003; 1: 2681-3.
18. Lee AY, Ginsberg JS. The role of D-dimer in the diagnosis of venous thromboembolism. Curr Opin Pulm Med 1997; 3: 275-9.
19. Perrier A, Desmarais S, Miron M-J et al. Non-invasive diagnosis of venous thromboembolism in outpatients. Lancet 1999; 353: 190-95.
20. Bernardi E, Prandoni P, Lensing AWA et al. D-dimer testing as an adjunct to ultrasonography in patients with clinically suspected deep vein thrombosis: prospective cohort study. BMJ 1998; 317: 1037-40.
21. Fancher TL, White RH, Kravitz RL. Combined use of rapid D-dimer testing and estimation of clinical probability in the diagnosis of deep vein thrombosis: systematic review. BMJ 2004; 329: 821. E-pub 2004 Sept 21.
22. Farrell S, Hayes T, Shaw M. A negative SimpliRED D dimer assay result does not exclude the diagnosis of deep vein thrombosis or pulmonary embolus in emergency department patients. Ann Emerg Med 2000; 35: 121-5.
23. Wells P, Anderson D, Rodger M et al. Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and D dimer. Ann Intern Med 2001; 135: 98-107.
24. ten Wolde M, Hagen P, MacGillavry M et al. Non invasive diagnostic work up of patients with suspected pulmonary embolism: preliminary results of a management study (Abstract). Thromb Haemost 2001; 7(Suppl.): 153.
25. Kruip M, Slob M, Schijen J, van der Heul C, Buller H. Use of clinical decision rule in combination with D dimer concentration in diagnostic workup of suspected pulmonary embolism: a prospective management study. Arch Intern Med 2002; 89: 1631-5.
26. Anderson D, Wells P, Kovacs M et al. Use of spiral computed tomography to exclude the diagnosis of pulmonary embolism in an emergency department (Abstract). Thromb Haemost 2001; 7(Suppl.): 156.
27. Hull R, Raskob G, Coates G, Panju A. Clinical validity of a normal perfusion lung scan in patients with suspected pulmonary embolism. Chest 1990; 97: 23-6.
28. Van Beek E, Kuyer P, Schenk B, Brandjes D, ten Cate J, Buller H. A normal perfusion lung scan in patients with clinically suspected pulmonary embolism: frequency and clinical validity. Chest 1995; 108: 170-73.
29. Van Beek E, Ginsberg J, Hirsh J, Buller H. Diagnosis of pulmonary embolism. In: Colman R, Hirsh J, Marder V, Clowes A, George J (eds). Haemostasis and Thrombosis, 4th edn. Lippincott Williams & Wilkins, Philadelphia, 2001; 1303.
30. Garg K, Sieler H, Welsh C, Johnston R, Russ P. Clinical validity of helical CT being interpreted as negative pulmonary embolism: implications for patient treatment. AJR 1999; 172: 1627-31.
31. Gottsater A, Berg A, Centergard J, Frennby B, Nirhov N, Nyman U. Clinically suspected pulmonary embolism: is it safe to withhold anticoagulation after a negative spiral CT? Eur Radiol 2001; 11: 65-72.
32. Lomis N, Yoon H, Moran A, Miller F. Clinical outcomes of patients after a negative spiral CT pulmonary arteriogram in the evaluation of acute pulmonary embolism. J Vasc Interv Radiol 1999; 10: 707-12.
33. Goodman L, Lipchik R, Kuzo R, Liu Y, McAuliffe T, O'Brien D. Subsequent pulmonary embolism: risk after a negative helical CT pulmonary angiogram - prospective comparison with scintigraphy. Radiology 2000; 215: 535-42.
34. Swensen S, Sheedy PF II, Ryu J et al. Outcomes after withholding anticoagulation from patients with suspected acute pulmonary embolism and negative computed tomographic findings: a cohort study. Mayo Clin Proc 2002; 77: 130-38.
35. Ferretti G, Bosson J, Buffaz P et al. Acute pulmonary embolism: role of helical CT in 164 patients with intermediate probability at ventilation scintigraphy and normal results at duplex US of legs. Radiology 1997; 205: 453-8.
36. Ost D, Rozenshtein A, Saffran L, Snider A. The negative predictive value of a spiral computed tomography for the diagnosis of pulmonary embolism in patients with non diagnostic ventilation-perfusion scans. Am J Med 2001; 110: 16-21.
37. Stein PD, Henry JW. Prevalence of acute pulmonary embolism in central and subsegmental pulmonary arteries and relation to probability interpretation of ventilation/perfusion lung scans. Chest 1997; 111: 1246-8.
38. Baile EM, King GG, Muller NL et al. Spiral computed tomography is comparable to angiography for the diagnosis of pulmonary embolism. Am J Respir Crit Care Med 2000; 161: 1010-15.
39. Diffin DC, Leyendecker JR, Johnson SP, Zucker RJ, Grebe PJ. Effect of anatomic distribution of pulmonary emboli on interobserver agreement in the interpretation of pulmonary angiography. AJR 1998; 171: 1085-9.
40. Tillie-Leblond I, Mastora I, Radenne F et al. Risk of pulmonary embolism after a negative spiral CT angiogram in patients with pulmonary disease: 1-year clinical follow-up study. Radiology 2002; 223: 461-7.
41. Carson JL, Terrin ML, Duff A, Kelley MA. Pulmonary embolism and mortality in patients with COPD. Chest 1996; 110: 1212-19.
42. Chartrand-Levebvre C, Howarth N, Lucidarme O et al. Contrast enhanced helical CT for pulmonary embolism detection: inter- and intraobserver agreement among radiologists with variable experience. AJR 1999; 172: 107-12.
43. Ginsberg J, Panicek D. Comparison of interpretations of CT angiograms in the evaluation of suspected pulmonary embolism by on-call radiology fellows and subsequently by radiology faculty. AJR 2004; 182: 61-6.