Chemoradiotherapy of anal cancer is feasible in elderly patients: Treatment results of mitomycin-5-FU combined with radiotherapy at Helsinki University Central Hospital 1992-2003

Acta Oncologica

Volumn 45, Issue 6, 2006, Pages 736-742

  Saarilahti, Kauko ^a   Arponen, Päivi ^a   Vaalavirta, Leila ^a   Tenhunen, Mikko ^a   Blomqvist, Carl ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; MITOMYCIN;

ADULT; AGED; ANUS CANCER; ARTICLE; BLOOD TOXICITY; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CARDIOTOXICITY; CONTROLLED STUDY; CYSTITIS; DIARRHEA; DIGESTIVE SYSTEM FISTULA; DOSE RESPONSE; FEMALE; FINLAND; HUMAN; INFECTION; LIFE EXPECTANCY; MAJOR CLINICAL STUDY; MALE; MUCOSAL DISEASE; MULTIMODALITY CANCER THERAPY; ORGAN PRESERVATION; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROCTITIS; RASH; SKIN ATROPHY; SKIN ULCER; STOMATITIS; TELANGIECTASIA; TREATMENT CONTRAINDICATION; TREATMENT OUTCOME; UNIVERSITY HOSPITAL;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANUS NEOPLASMS; FEMALE; FINLAND; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MITOMYCIN; RADIOTHERAPY; TREATMENT OUTCOME;

EID: 33748669444     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.1080/02841860600849075     Document Type: Article

References (23)

1. Life expectation tables: Statistics Finland. Media and Communication Unit.Viestinta@stat.fi.
2. Cancer Statistics: Finnish Cancer Registry. Personal communication.
3. Ryan DP, Compton CC, Mayer RJ. Carcinoma of the anal canal. N Engl J Med 2000;342:792-800.
4. Clark MA, Hartley A, Geh JI. Cancer of the anal canal. Lancet Oncol 2004;5:149-57.
5. Nigro ND, Vaitkevicius VK, Considine B, Jr. Combined therapy for cancer of the anal canal: A preliminary report. Dis Colon Rectum 1974;17:354-6.
6. Arnott SJ, Cunningham D, Gallagher J, Gray R, Hardcastle J, Houghton J, et al. Epidermoid anal cancer: Results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. Lancet 1996; 348:1049-54.
7. Bosset JF, Pavy JJ, Roelofsen F, Bartelink H. Combined radiotherapy and chemotherapy for anal cancer. EORTC Radiotherapy and Gastrointestinal Cooperative Groups. Lancet 1997;349:205-6.
8. Bartelink H, Roelofsen F, Eschwege F, Rougier P, Bosset JF, Gonzalez DG, et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: Results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol 1997;15:2040-9.
9. TNM classification of malignant tumors. Lippincott: UICC; 1997.
10. Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995;31:1341-6.
11. Balducci L, Beghe C. Cancer and age in the USA. Crit Rev Oncol Hematol 2001;37:137-45.
12. Carreca I, Balducci L, Extermann M. Cancer in the older person. Cancer Treat Rev 2005;31:380-402.
13. Vrakking AM, van der Heide A, van Delden JJ, Looman CW, Visser MH, van der Maas PJ. Medical decision-making for seriously ill non-elderly and elderly patients. Health Policy 2005;75:40-8.
14. Fried TR, Pollack DM, Tinetti ME. Factors associated with six-month mortality in recipients of community-based long-term care. J Am Geriatr Soc 1998;46:193-7.
15. Gosney MA. Clinical assessment of elderly people with cancer. Lancet Oncol 2005;6:790-7.
16. Bernardi D, Barzan L, Franchin G, Cinelli R, Balestreri L, Tirelli U, et al. Treatment of head and neck cancer in elderly patients: State of the art and guidelines. Crit Rev Oncol Hematol 2005;53:71-80.
17. Sarini J, Fournier C, Lefebvre JL, Bonafos G, Van JT, Coche-Dequeant B. Head and neck squamous cell carcinoma in elderly patients: A long-term retrospective review of 273 cases. Arch Otolaryngol Head Neck Surg 2001;127:1089-92.
18. Rice DC, Correa AM, Vaporciyan AA, Sodhi N, Smythe WR, Swisher SG, et al. Preoperative chemoradiotherapy prior to esophagectomy in elderly patients is not associated with increased morbidity. Ann Thorac Surg 2005;79:391-7. Discussion 391-7.
19. Abir F, Alva S, Longo WE. The management of rectal cancer in the elderly. Surg Oncol 2004;13:223-34.
20. Fratino L, Bernardi D. European experiences on aggressive non-Hodgkin's lymphoma in elderly patients. Crit Rev Oncol Hematol 2004;51:229-40.
21. Maione P, Perrone F, Gallo C, Manzione L, Piantedosi F, Barbera S, et al. Pretreatment quality of life and functional status assessment significantly predict survival of elderly patients with advanced non-small-cell lung cancer receiving chemotherapy: A prognostic analysis of the multicenter Italian lung cancer in the elderly study. J Clin Oncol 2005; 23:6865-72.
22. Allal AS, Obradovic M, Laurencet F, Roth AD, Spada A, Marti MC, et al. Treatment of anal carcinoma in the elderly: Feasibility and outcome of radical radiotherapy with or without concomitant chemotherapy. Cancer 1999;85:26-31.
23. de Gara CJ, Basrur V, Figueredo A, Goodyear M, Knight P. The influence of age on the management of anal cancer. Hepatogastroenterology 1995;42:73-6.