메뉴 건너뛰기




Volumn 25, Issue 5, 2006, Pages 361-371

Toxicity studies of Blockal, a dietary supplement containing Phase 2 Starch Neutralizer (Phase 2), a standardized extract of the common white kidney bean (Phaseolus vulgaris)

Author keywords

Amylase Inhibitor; Phase 2; Phaseolus vulgaris; Safety; Starch Blocker; Toxicity

Indexed keywords

AMYLASE INHIBITOR; PHASEOLUS VULGARIS EXTRACT; PLANT EXTRACT; STARCH; UNCLASSIFIED DRUG;

EID: 33748650306     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1080/10915810600846229     Document Type: Article
Times cited : (31)

References (29)
  • 1
    • 0020672147 scopus 로고
    • Phytohemagglutinin derived from red kidney bean (Phaseolus vulgaris): A cause for intestinal malabsorption associated with bacterial overgrowth in the rat
    • Banwell, J., D. Boldt, J. Meyers, and F. Weber. 1983. Phytohemagglutinin derived from red kidney bean (Phaseolus vulgaris): A cause for intestinal malabsorption associated with bacterial overgrowth in the rat. Gastroenterology 84:506-515.
    • (1983) Gastroenterology , vol.84 , pp. 506-515
    • Banwell, J.1    Boldt, D.2    Meyers, J.3    Weber, F.4
  • 2
    • 0001138307 scopus 로고
    • Amylase inhibitor of navy beans
    • Bowman, D. 1945. Amylase inhibitor of navy beans. Science 102:358-359.
    • (1945) Science , vol.102 , pp. 358-359
    • Bowman, D.1
  • 3
    • 2342458981 scopus 로고    scopus 로고
    • Suspected white kidney bean (Phaseolus vulgaris) toxicity in horses and cattle
    • Carmalt, J., K. Rosel, T. Burns, and E. Janzen. 2003. Suspected white kidney bean (Phaseolus vulgaris) toxicity in horses and cattle. Aust. Vet. J. 81:674-676.
    • (2003) Aust. Vet. J. , vol.81 , pp. 674-676
    • Carmalt, J.1    Rosel, K.2    Burns, T.3    Janzen, E.4
  • 4
    • 0344406675 scopus 로고    scopus 로고
    • Local (gut) and systemic metabolism of rats is altered by consumption of raw bean (Phaseolus vulgaris L. var. athropurpurea)
    • Cavalle de Moya, C., G. Grant, G. Fruhbeck, E. Urdaneta, M. Garcia, F. Marzo, and S. Santidrian. 2003. Local (gut) and systemic metabolism of rats is altered by consumption of raw bean (Phaseolus vulgaris L. var. athropurpurea). Br. J. Nutr. 89:311-318.
    • (2003) Br. J. Nutr. , vol.89 , pp. 311-318
    • Cavalle De Moya, C.1    Grant, G.2    Fruhbeck, G.3    Urdaneta, E.4    Garcia, M.5    Marzo, F.6    Santidrian, S.7
  • 6
    • 0028821545 scopus 로고
    • Consumption of diets containing raw soya beans (Glycine max), kidney beans (Phaseolus vulgaris), cowpeas (Vigna, unguiculata) or lupin seeds (Lupinus angustifolius) by rats for up to 700 days: Effects on body composition and organ weights
    • Grant, G., P. Dorward, W. Buchan, J. Armour, and A. Pusztai. 1995. Consumption of diets containing raw soya beans (Glycine max), kidney beans (Phaseolus vulgaris), cowpeas (Vigna, unguiculata) or lupin seeds (Lupinus angustifolius) by rats for up to 700 days: Effects on body composition and organ weights. Br. J. Nutr. 73:17-29.
    • (1995) Br. J. Nutr. , vol.73 , pp. 17-29
    • Grant, G.1    Dorward, P.2    Buchan, W.3    Armour, J.4    Pusztai, A.5
  • 7
    • 0023645409 scopus 로고
    • Oligosaccharide specificities of Phaseolus vulgaris leukoagglutinating and erythroagglutinating phytohemagglutinins: Interactions with N-glycanase-released oligosaccharides
    • Green, E., and J. Baenziger. 1987. Oligosaccharide specificities of Phaseolus vulgaris leukoagglutinating and erythroagglutinating phytohemagglutinins: Interactions with N-glycanase-released oligosaccharides. J. Biol. Chem. 262:12018-12029.
    • (1987) J. Biol. Chem. , vol.262 , pp. 12018-12029
    • Green, E.1    Baenziger, J.2
  • 8
    • 0022087225 scopus 로고
    • Effect of kidney bean (Phaseolus vulgaris) toxin on tissue weight and composition and some metabolic functions of rats
    • Greer, F., A. Brewer, and A. Pusztai. 1985. Effect of kidney bean (Phaseolus vulgaris) toxin on tissue weight and composition and some metabolic functions of rats. Br. J. Nutr. 54:95-103.
    • (1985) Br. J. Nutr. , vol.54 , pp. 95-103
    • Greer, F.1    Brewer, A.2    Pusztai, A.3
  • 9
    • 0018380466 scopus 로고
    • Poisoning by raw garden beans (Phaseolus vulgaris and Phaseolus coccineus) in children
    • Haidvogl, M., G. Fritsch, and H. Grubauer. 1979. Poisoning by raw garden beans (Phaseolus vulgaris and Phaseolus coccineus) in children. Padiatrie Padologi 14:293.
    • (1979) Padiatrie Padologi , vol.14 , pp. 293
    • Haidvogl, M.1    Fritsch, G.2    Grubauer, H.3
  • 10
    • 0004277525 scopus 로고
    • Cited. (unpublished). Available through
    • Cited in Duke., J.A. 1983. Handbook of energy crops (unpublished). Available through Purdue University Center for New Crops and Plant Products website http://www.hort.purdue.edu/newcrop/default.html.
    • (1983) Handbook of Energy Crops
    • Duke, J.A.1
  • 12
    • 20544453094 scopus 로고    scopus 로고
    • A preliminary assessment of the acute and subchronic toxicity profile of Phase 2: An α-amylase inhibitor
    • Harikumar, K., A. Jesil, M. Sabu, and R. Kuttan. 2005. A preliminary assessment of the acute and subchronic toxicity profile of Phase 2: An α-amylase inhibitor. Int. J. Toxicol. 24:95-102.
    • (2005) Int. J. Toxicol. , vol.24 , pp. 95-102
    • Harikumar, K.1    Jesil, A.2    Sabu, M.3    Kuttan, R.4
  • 13
    • 0025598932 scopus 로고
    • Comparison of growth, nitrogen metabolism and organ weight in piglets and rats fed on diets containing Phaseolus vulgaris beans
    • Huisman, J., A. van der Poel, P. van Leewen, and M. Verstegen. 1990. Comparison of growth, nitrogen metabolism and organ weight in piglets and rats fed on diets containing Phaseolus vulgaris beans. Br. J. Nutr. 64:743-753.
    • (1990) Br. J. Nutr. , vol.64 , pp. 743-753
    • Huisman, J.1    Van Der Poel, A.2    Van Leewen, P.3    Verstegen, M.4
  • 14
    • 33748662053 scopus 로고    scopus 로고
    • Institute of Medicine and National Research Council of the National Academies
    • IOM/NRC. 2004. Prototype monograph on chromium picolinate. Institute of Medicine and National Research Council of the National Academies. Available on-line through http://www.iom.edu.
    • (2004) Prototype Monograph on Chromium Picolinate
  • 15
    • 0025482606 scopus 로고
    • Pathologic changes of the small intestinal mucosa of pigs after feeding Phaseolus vulgaris beans
    • Kik, M., J. Huisman, A. van der Poel, and J. Mouwen. 1990. Pathologic changes of the small intestinal mucosa of pigs after feeding Phaseolus vulgaris beans. Vet. Pathol. 27:329-334.
    • (1990) Vet. Pathol. , vol.27 , pp. 329-334
    • Kik, M.1    Huisman, J.2    Van Der Poel, A.3    Mouwen, J.4
  • 16
    • 0011275949 scopus 로고
    • An amylase inhibitor from certain cereals
    • Kneen, E., and R. Sandstedt. 1943. An amylase inhibitor from certain cereals. J. Am. Chem. Soc. 65:1247.
    • (1943) J. Am. Chem. Soc. , vol.65 , pp. 1247
    • Kneen, E.1    Sandstedt, R.2
  • 17
    • 0001847507 scopus 로고
    • Partial characterization of the amylase inhibitor of black beans (Phaseolus vulgaris), variety Rico 23
    • Lajolo, F., and F. Finardi Filho. 1985. Partial characterization of the amylase inhibitor of black beans (Phaseolus vulgaris), variety Rico 23. J. Agric. Food Chem. 33:132-138.
    • (1985) J. Agric. Food Chem. , vol.33 , pp. 132-138
    • Lajolo, F.1    Finardi Filho, F.2
  • 18
    • 0016748322 scopus 로고
    • Purification and properties of phaseolamin, an inhibitor of α- amylase, from the kidney bean, Phaseolus vulgaris
    • Marshall, J., and C. Lauda. 1975. Purification and properties of phaseolamin, an inhibitor of α- amylase, from the kidney bean, Phaseolus vulgaris. J. Biol. Chem. 250:8030-8037.
    • (1975) J. Biol. Chem. , vol.250 , pp. 8030-8037
    • Marshall, J.1    Lauda, C.2
  • 19
    • 0020214347 scopus 로고
    • Protein utilization and toxic effects of raw beans (Phaseolus vulgaris) for young pigs
    • Myer, R., J. Froseth, and C. Coon. 1982. Protein utilization and toxic effects of raw beans (Phaseolus vulgaris) for young pigs. J. Anim. Sci. 55:1087-1098.
    • (1982) J. Anim. Sci. , vol.55 , pp. 1087-1098
    • Myer, R.1    Froseth, J.2    Coon, C.3
  • 20
    • 0033092877 scopus 로고    scopus 로고
    • Performance of beef cows receiving cull beans, sunflower meal, and canola meal as protein supplements while grazing native winter range in Eastern Colorado
    • Patterson, H., J. Wittier, L. Rittenhouse, and D. Schutz. 1999. Performance of beef cows receiving cull beans, sunflower meal, and canola meal as protein supplements while grazing native winter range in Eastern Colorado. J. Anim. Sci. 77:750-755.
    • (1999) J. Anim. Sci. , vol.77 , pp. 750-755
    • Patterson, H.1    Wittier, J.2    Rittenhouse, L.3    Schutz, D.4
  • 21
    • 84986513593 scopus 로고
    • Purification and some physical and chemical properties of red kidney bean (Phaseolus vulgaris) α-amylase inhibitor
    • Powers, J., and J. Whitaker. 1977a. Purification and some physical and chemical properties of red kidney bean (Phaseolus vulgaris) α-amylase inhibitor. J. Food Biochem. 1:217-238.
    • (1977) J. Food Biochem. , vol.1 , pp. 217-238
    • Powers, J.1    Whitaker, J.2
  • 22
    • 84986431200 scopus 로고
    • Effect of several experimental parameters on combination of red kidney bean (Phaseolus vulgaris) α-amylase inhibitor with porcine pancreatic α-amylase
    • Powers, J., and J. Whitaker. 1977b. Effect of several experimental parameters on combination of red kidney bean (Phaseolus vulgaris) α-amylase inhibitor with porcine pancreatic α-amylase. J. Food Biochem. 1:239-260.
    • (1977) J. Food Biochem. , vol.1 , pp. 239-260
    • Powers, J.1    Whitaker, J.2
  • 23
    • 0020033065 scopus 로고
    • Recent advances in the study of the nutritional toxicity of kidney bean (Phaseolus vulgaris) lectins in rats
    • Pusztai, A., T. P. King, and E. Clarke. 1982. Recent advances in the study of the nutritional toxicity of kidney bean (Phaseolus vulgaris) lectins in rats. Toxicon 20:195-197.
    • (1982) Toxicon , vol.20 , pp. 195-197
    • Pusztai, A.1    King, T.P.2    Clarke, E.3
  • 24
    • 0025677398 scopus 로고
    • Red kidney bean poisoning in the UK: An analysis of 50 suspected incidents between 1976 and 1989
    • Rodhouse, J., C. Haugh, D. Roberts, and R. Gilbert. 1990. Red kidney bean poisoning in the UK: An analysis of 50 suspected incidents between 1976 and 1989. Epidemiol. Infect. 105:485-491.
    • (1990) Epidemiol. Infect. , vol.105 , pp. 485-491
    • Rodhouse, J.1    Haugh, C.2    Roberts, D.3    Gilbert, R.4
  • 25
    • 0027910020 scopus 로고
    • Foodborne disease surveillance in England and Wales: 1989-1991
    • Review Number 12 (5 November 1993). Public Health Laboratory Service, Communicable Disease Surveillance Centre
    • S. Sockett, P., J. Cowden, S. Le Baigue, D. Ross, G. K. Adak, and H. Evans. 1993. Foodborne disease surveillance in England and Wales: 1989-1991. Communicable Disease Report, Volume 3, Review Number 12 (5 November 1993), R168. Public Health Laboratory Service, Communicable Disease Surveillance Centre. Available on-line through http://www.hpa.org.uk/cdr/back issues.htm#reviews.
    • (1993) Communicable Disease Report , vol.3
    • Sockett, S.1    Cowden, J.2    Le Baigue, S.3    Ross, D.4    Adak, G.K.5    Evans, H.6
  • 26
  • 28
    • 33748655710 scopus 로고    scopus 로고
    • personal communication. Mark A. Uebersax, Ph.D., Professor and Chairperson, Michigan State University Department of Food Science and Human Nutrition
    • Uebersax, M. A., personal communication. Mark A. Uebersax, Ph.D., Professor and Chairperson, Michigan State University Department of Food Science and Human Nutrition.
    • Uebersax, M.A.1
  • 29
    • 0021759424 scopus 로고
    • Some aspects of the mechanism of complexation of red kidney bean α-amylase inhibitor and α-amylase
    • Wilcox, E., and J. Whitaker. 1984. Some aspects of the mechanism of complexation of red kidney bean α-amylase inhibitor and α-amylase. Biochemistry 23:1783-1791.
    • (1984) Biochemistry , vol.23 , pp. 1783-1791
    • Wilcox, E.1    Whitaker, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.