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37049067860
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for '2,5-cis'-selective cyclisation of the allenic amine derivatives, see also: R. Kinsman, D. Lathbury, P. Vernon and T. Gallagher, J. Chem. Soc., Chem. Commun., 1987, 243.
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H. Izawa, R. Shirai, H. Kawasaki, H.-D. Kim and K. Koga, Tetrahedron Lett., 1989, 30, 7221;
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R. Shirai, K. Aoki, D. Sato, H.-D. Kim, M. Murakata, T. Yasukata and K. Koga, Chem. Pharm. Bull., 1994, 42, 690.
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Simpkins' group has also studied similar HCLA (homochiral lithium amide) chemistry, see: P. J. Cox and N. S. Simpkins, Tetrahedron: Asymmetry, 1992, 2, 1.
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(b) T. Momose, N. Toyooka, S. Seki and Y. Hirai, Chem. Pharm. Bull., 1990, 38, 2072.
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0029115128
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Majewski's group has also investigated the enantioselective deprotonation of tropinone using HCLA and reaction of the chiral lithium enolate of tropinone: M. Majewski and R. Lazny, J. Org. Chem., 1995, 60, 5825 and references cited therein.
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0012047909
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For 9-benzyl-9-azabicyclo[3.3.1]nonan-3-one, see: K. Stach and O. Dold, Arzneim. Forsch., 1962, 12, 1022. The procedure was partially modified in the present work: see Experimental section.
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Stach, K.1
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13344268078
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For 8-benzyl-8-azabicyclo[3.2.1]octan-3-one, see: K. Nádor, Gy. Hajdu, B. Szecsö and F. Zima, Arzneim. Forsch., 1962, 12, 305.
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85087582491
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note
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1OH(10:1).
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0000656820
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for other syntheses of dihydropinidine, see: M. Bonin, J. R. Romero, D. S. Grierson and H.-P. Husson, Tetrahedron Lett., 1982, 23, 3369;
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M. Amat, N. Llor, J. Hidalgo, A. Hernandez and J. Bosch, Tetrahedron: Asymmetry, 1996, 7, 977 and references cited therein.
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