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Professor J. Liebscher's group (Humboldt-Universität zu Berlin) has studied the alkylation of chiral 2-(sulfonamidomethyl)oxazolines and a manuscript concerning this work has been accepted for publication in Synthesis;, we thank Prof. Liebscher for this information. The alkylation of 2-(ω-aminoalkyl)oxazolines has also been studied: A. Rottman and J. Liebscher, Tetrahedron Lett., 1996, 37, 359.
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The expected products of such reactions, 2-(α-aminoalkyl)oxazolines, are usually prepared by cyclization of appropriate peptide precursors; for recent examples, see: (a) C. D. J. Boden and G. Pattenden, Tetrahedron Lett., 1995, 36, 6153;
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