Methadone doses upon multiple readmissions to inpatient detoxification: Clinical evidence for very moderate opioid tolerance

Pharmacology

Volumn 78, Issue 1, 2006, Pages 38-43

  Madlung, Ekkehard ^a   Haring, Christian ^a   Crespo, Jose A ^b   Saria, Alois ^b   Grubinger, Petra ^b   Zernig, Gerald ^b  

^a Primariat B   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Abuse; Allostasis; Clinical; Dependence; Heroin; Human; Methadone; Morphine; Opioid tolerance; Sensitization

Indexed keywords

METHADONE; OPIATE;

ANIMAL BEHAVIOR; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABUSE; DRUG DEPENDENCE; DRUG DETOXIFICATION; DRUG EFFECT; DRUG TOLERANCE; DRUG USE; DRUG WITHDRAWAL; FEMALE; HOSPITAL PATIENT; HOSPITAL READMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; OPIATE ADDICTION; PRIORITY JOURNAL; SENSITIZATION; SEX DIFFERENCE; WITHDRAWAL SYNDROME;

DRUG TOLERANCE; FEMALE; HUMANS; MALE; METHADONE; PATIENT READMISSION; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 33748642354     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095030     Document Type: Article

References (26)

1. American Psychiatric Association: Diagnostic Criteria from DSM-IV TM. Washington, American Psychiatric Association, 1994.
2. Deroche V, Le Moal M, Piazza PV: Cocaine self-administration increases the incentive motivational properties of the drug in rats. Eur J Neurosci 1999;11:2731-2736.
3. Berridge KC, Robinson TE: Parsing reward. Trends Neurosci 2003;26:507-513.
4. Robinson TE, Berridge KC: Incentive-sensitization and addiction. Addiction 2001;96:103-114.
5. Ahmed SH, Koob GF: Transition from moderate to excessive drug intake: change in hedonic set point. Science 1998;282:298-300.
6. Koob GF, Le Moal M: Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 2001;24:97-129.
7. Cardinal RN, Parkinson JA, Hall J, Everitt BJ: Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev 2002;26:321-352.
8. Bozarth MA: Methods of Assessing the Reinforcing Properties of Abused Drugs. New York, Springer, 1987.
9. Johanson CE, Schuster CR, Hatsukami D, Vocci F: Abuse liability assessment of CNS drugs. Drug Alcohol Depend 2003;70:S1-S114.
10. Woolverton WL, Nader MA: Experimental evaluation of the reinforcing effects of drugs. Modern Methods Pharmacol 1990;165-192.
11. Young AM, Herling S: Drugs as Reinforcers: Studies in Laboratory Animals. Orlando, Academic Press, 1986.
12. Woods JH, France CP, Winger G, Bertalmio AJ, Schwarz-Stevens K: Opioid Abuse Liability Assessment in Rhesus Monkeys. New York, Springer, 1993.
13. Zernig G, Wakonigg G, Madlung E, Haring C, Saria A: Do vertical shifts in dose-response rate-relationships in operant conditioning procedures indicate 'sensitization' to 'drug wanting'? Psychopharmacology 2004;171:349-351.
14. Robinson TE, Berridge KC: Incentive-sensitization and drug 'wanting'. Psychopharmacology 2004;17:352-353.
15. Ahmed SH, Koob GF: Vertical shifts in dose-injection curves reflect reward allostasis, not sensitization. Psychopharmacology 2004;171:354-355.
16. Katz JL, Higgins ST: What is represented by vertical shifts in self-administration dose-response curves? Psychopharmacology 2004;171:360-361.
17. Negus SS, Mello NK, Caine SB: The utility of 'tolerance' as a concept in the study of drug self-administration. Psychopharmacology 2004;171:362-363.
18. Piazza PV, Deroche V: What juxtaposition, tradition and parsimony can do to vertical shifts in drug self-administration dose-response functions. Psychopharmacology 2004;171:356-359.
19. deWit H, Griffiths RR: Testing the abuse liability of anxiolytic and hypnotic drugs in humans. Drug Alcohol Depend 1991;28:83-111.
20. Zernig G, deWit H, Telser S, Nienhusmeier M, Wakonigg G, Sturm K, et al: Subjective effects of slow-release bupropion vs. caffeine as determined in a quasi-naturalistic setting. Pharmacology 2004;70:206-215.
21. Zernig G, Giacomuzzi S, Riemer Y, Wakonigg G, Sturm K, Saria A: Intravenous drug injection habits: drug users' self-reports vs. researchers' perception. Pharmacology 2003;976:49-56.
22. Negus SS, Mello NK: Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a second-order schedule in rhesus monkeys. Drug Alcohol Depend 2003;70:39-52.
23. Winger G, Woods JH: The effects of chronic morphine on behavior reinforced by several opioids or by cocaine in rhesus monkeys. Drug Alcohol Dep 2001;62:181-189.
24. Gossop M: The development of a Short Opiate Withdrawal Scale (SOWS). Addict Behav 1990;15:487-490.
25. Wilder A: A psychodynamic study of a patient during experimental self-regulated readdiction to morphine. Psychiatr Q 1952;26:270-293.
26. Negus SS: Choice between heroin and food in non-dependent and heroin-dependent rhesus monkeys: effects of naloxone, buprenorphine and methadone. J Pharmacol Exp Ther 2006;317:711-723.