Selectin inhibition modulates NF-κB and AP-1 signaling after liver ischemia/reperfusion

Journal of Investigative Surgery

Volumn 19, Issue 5, 2006, Pages 313-322

  Toledo Pereyra, Luis H ^a,b   Lopez Neblina, Fernando ^a   Lentsch, Alex B ^c   Anaya Prado, Roberto ^d   Romano, Suzanne J ^e   Ward, Peter A ^f  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

^d Borgess Research Institute   (United States)

^e Ontogen Laboratories   (United States)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

AP 1; Liver ischemia; NF B; Selectin inhibition

Indexed keywords

3 [4 [5 [4 (2 DIHEXYLCARBAMOYLVINYL)PHENYL] 1H IMIDAZOL 4 YL]PHENYL]ACRYLIC ACID; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIVER EXTRACT; OC 229; SELECTIN; SELECTIN ANTAGONIST; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANALYTICAL PARAMETERS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL MODEL; GEL MOBILITY SHIFT ASSAY; HISTOPATHOLOGY; INFLAMMATION; LIVER FUNCTION TEST; LIVER HISTOLOGY; LIVER ISCHEMIA; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CINNAMATES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; IMIDAZOLES; LIVER; MALE; MICE; MICE, INBRED C57BL; NEUTROPHILS; NF-KAPPA B; REPERFUSION INJURY; SELECTINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 33748634367     PISSN: 08941939     EISSN: 15210553     Source Type: Journal    
DOI: 10.1080/08941930600889474     Document Type: Article

References (51)

1. Misawa, K and Toledo-Pereyra, L and Phillips, M and Garcia-Cirado, F and Lopez-Neblina, F and Paez-Rollys, A. (1996) Role of sialyl Lewis(x) in total hepatic ischemia and reperfusion J Am Coll Surg, 182, pp. 251-256. http://www4.infotrieve.com/newmedline/detail.asp?NameID= 8603246&Session=&searchQuery=J+Am+Coll+Surg%5BJournal+Name%5D+ AND+182%5BVolume%5D+AND+251%5BPage+Number%5D+AND+1996%5BPublication+ Date%5D+AND+Misawa%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=1072-7515&vol= 182&iss=&firstpage=251
2. Garcia-Criado, F and Toledo-Pereyra, L and Lopez-Neblina, F and Phillips, M and Paez-Rollys, A and Misawa, K. (1995) Role of P-selectin in total hepatic ischemia and reperfusion J Am Coll Surg, 181, pp. 327-334. http://www4.infotrieve.com/newmedline/detail.asp?NameID= 7551327&Session=&searchQuery=J+Am+Coll+Surg%5BJournal+Name%5D+ AND+181%5BVolume%5D+AND+327%5BPage+Number%5D+AND+1995%5BPublication+ Date%5D+AND+Garcia%2DCriado%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1072-7515&vol=181&iss=&firstpage=327
3. Hicks, A and Nolan, S and Ridger, V and Hellewell, P and Norman, K. (2003) Recombinant P-selectin glycoprotein ligand-1 directly inhibits leukocyte rolling by all 3 selectins in vivo: Complete inhibition of rolling is not required for anti-inflammatory effect Blood, 101, pp. 3249-3256. http://www4.infotrieve.com/newmedline/detail.asp?NameID= 12480716&Session=&searchQuery=Blood%5BJournal+Name%5D+AND+ 101%5BVolume%5D+AND+3249%5BPage+Number%5D+AND+2003%5BPublication+ Date%5D+AND+Hicks%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0006-4971&vol=101&iss=&firstpage=3249 http://dx.doi.org/10.1182%2Fblood-2002-07-2329
4. Nemoto, T and Burne, M and Daniels, F and O'Donnell, M and Crosson, J and Berens, K and Issekutz, A and Kasiske, B and Keane, W and Rabb, H. (2001) Small molecule selectin ligand inhibition improves outcome in ischemic acute renal failure Kidney Int, 60, pp. 2205-2214. http://www4.infotrieve.com/newmedline/detail.asp?NameID= 11737594&Session=&searchQuery=Kidney+Int%5BJournal+Name%5D+ AND+60%5BVolume%5D+AND+2205%5BPage+Number%5D+AND+2001%5BPublication+ Date%5D+AND+Nemoto%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0098-6577&vol=60&iss=&firstpage=2205 http://dx.doi.org/10.1046%2Fj.1523-1755.2001.00054.x
5. Martinez-Mier, G and Toledo-Pereyra, L and McDuffie, J and Warner, R and Ward, P. (2000) P-selectin and chemokine response after liver ischemia and reperfusion J Am Coll Surg, 191, pp. 395-402. http://www4.infotrieve.com/newmedline/detail.asp?NameID= 11030245&Session=&searchQuery=J+Am+Coll+Surg%5BJournal+Name%5D+ AND+191%5BVolume%5D+AND+395%5BPage+Number%5D+AND+2000%5BPublication+ Date%5D+AND+Martinez%2DMier%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1072-7515&vol=191&iss=&firstpage=395 http://dx.doi.org/10.1016%2FS1072-7515%2800%2900360-4
6. Takahashi, Y and Ganster, R and Gambotto, A and Shao, L and Kaizu, T and Wu, T and Yagnik, G and Nakao, A and Tsoulfas, G and Ishikawa, T and Okuda, T and Geller, D and Murase, N. (2002) Role of NF-kappaB on liver cold ischemia-reperfusion injury Am J Physiol Gastrointest Liver Physiol, 283, pp. G1175-G1184. http://www4.infotrieve.com/newmedline/detail.asp?NameID= 12381532&Session=&searchQuery=Am+J+Physiol+Gastrointest+Liver+ Physiol%5BJournal+Name%5D+AND+283%5BVolume%5D+AND+G1175%5BPage+ Number%5D+AND+2002%5BPublication+Date%5D+AND+Takahashi%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0193-1857&vol=283&iss=&firstpage=G1175
7. Zingarelli, B and Hake, P and Yang, Z and O'Connor, M and Denenberg, A and Wong, H. (2002) Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappaB and AP-1 activation and enhances myocardial damage FASEB J, 16, pp. 327-342. http://www4.infotrieve.com/newmedline/detail.asp?NameID= 11874982&Session=&searchQuery=FASEB+J%5BJournal+Name%5D+AND+ 16%5BVolume%5D+AND+327%5BPage+Number%5D+AND+2002%5BPublication+Date%5D+ AND+Zingarelli%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0892-6638&vol=16&iss=&firstpage=327 http://dx.doi.org/10.1096%2Ffj.01-0533com
8. Takeuchi, D and Yosidome, H and Kato, A and (2004) Interleukin 18 causes hepatic ischemia/reperfusion injury by suppressing anti-inflammatory cytokine expression in mice Hepatology, 39, pp. 699-710. http://www4.infotrieve.com/newmedline/detail.asp?NameID= 14999688&Session=&searchQuery=Hepatology%5BJournal+Name%5D+AND+ 39%5BVolume%5D+AND+699%5BPage+Number%5D+AND+2004%5BPublication+Date%5D+ AND+Takeuchi%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1386-6346&vol=39&iss=&firstpage=699 http://dx.doi.org/10.1002%2Fhep.20117
9. Das, D and Maulik, N. (2003) Preconditioning potentiates redox signaling and converts death signal into survival signal Arch Biochem Biophys, 420, pp. 305-311. http://www4.infotrieve.com/newmedline/detail.asp?NameID= 14654070&Session=&searchQuery=Arch+Biochem+Biophys%5BJournal+ Name%5D+AND+420%5BVolume%5D+AND+305%5BPage+Number%5D+AND+ 2003%5BPublication+Date%5D+AND+Das%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0003-9861&vol=420&iss=&firstpage=305 http://dx.doi.org/10.1016%2Fj.abb.2003.09.023
10. Slee, D and Romano, S and Yu, J and Nguyen, T and John, J and Raheja, N and Axe, F and Jones, T and Ripka, W. (2001) Development of potent non-carbohydrate imidazole-based small molecule selectin inhibitors with antiinflammatory activity J Med Chem, 44, pp. 2094-2107. http://www4.infotrieve.com/newmedline/detail.asp?NameID= 11405647&Session=&searchQuery=J+Med+Chem%5BJournal+Name%5D+ AND+44%5BVolume%5D+AND+2094%5BPage+Number%5D+AND+2001%5BPublication+ Date%5D+AND+Slee%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-2623&vol=44&iss=&firstpage=2094 http://dx.doi.org/10.1021%2Fjm000508c
11. Suzuki, S and Toledo-Pereyra, L and Rodriguez, F and Cejalvo, D. (1993) Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury Transplantation, 55, pp. 1265-1272. http://www4.infotrieve.com/newmedline/detail.asp?NameID= 7685932&Session=&searchQuery=Transplantation%5BJournal+Name%5D+ AND+55%5BVolume%5D+AND+1265%5BPage+Number%5D+AND+1993%5BPublication+ Date%5D+AND+Suzuki%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0041-1337&vol=55&iss=&firstpage=1265
12. Deryckere, F and Gannon, F. (1994) A one-hour mini-preparation technique for extraction of DNA-binding proteins from animal tissues Biotechniques, 16, pp. 405. http://www4.infotrieve.com/newmedline/detail.asp?NameID=8185907 &Session=&searchQuery=Biotechniques%5BJournal+Name%5D+ AND+16%5BVolume%5D+AND+405%5BPage+Number%5D+AND+1994%5BPublication+ Date%5D+AND+Deryckere%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0736-6205&vol=16&iss=&firstpage=405
13. Kakkar, A and Lefer, D. (2004) Leukocyte and endothelial adhesion molecule studies in knockout mice Curr Opin Pharmacol, 4, pp. 154-158. http://www4.infotrieve.com/newmedline/detail.asp?NameID=15063359 &Session=&searchQuery=Curr+Opin+Pharmacol%5BJournal+Name%5D+ AND+4%5BVolume%5D+AND+154%5BPage+Number%5D+AND+2004%5BPublication+ Date%5D+AND+Kakkar%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1471-4892&vol=4&iss=&firstpage=154 http://dx.doi.org/10.1016%2Fj.coph.2004.01.003
14. Romano, S and Slee, D. (2001) Targeting selectins for the treatment of respiratory diseases Curr Opin Investig Drugs, 2, pp. 907-913. http://www4.infotrieve.com/newmedline/detail.asp?NameID=11757789 &Session=&searchQuery=Curr+Opin+Investig+Drugs%5BJournal+ Name%5D+AND+2%5BVolume%5D+AND+907%5BPage+Number%5D+AND+ 2001%5BPublication+Date%5D+AND+Romano%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1472-4472&vol=2&iss=&firstpage=907
15. Romano, S. (2005) Selectin antagonists: Therapeutic potential in asthma and COPD Treat Respir Med, 4, pp. 85-94. http://www4.infotrieve.com/newmedline/detail.asp?NameID=15813660 &Session=&searchQuery=Treat+Respir+Med%5BJournal+Name%5D+ AND+4%5BVolume%5D+AND+85%5BPage+Number%5D+AND+2005%5BPublication+ Date%5D+AND+Romano%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1176-3450&vol=4&iss=&firstpage=85 http://dx.doi.org/10.2165%2F00151829-200504020-00002
16. Toledo-Pereyra, L and Lopez-Neblina, F and Reuben, J and (2004) Selectin inhibition modulates Akt/MAPK signaling and chemokine expression after liver ischemia-reperfusion J Invest Surgery, 17, pp. 303-313. http://www.csa.com/htbin/linkabst.cgi?issn=0894-1939&vol=17&iss= &firstpage=303 http://dx.doi.org/10.1080%2F08941930490884706
17. Rivera-Chavez, F and Toledo-Pereyra, L and Nora, D and Bachulis, B and Ilgenfritz, F and Dean, R. (1998) P-selectin blockade is beneficial after uncontrolled hemorrhagic shock J Trauma, 45, pp. 404-409. http://www.csa.com/htbin/ linkabst.cgi?issn=0894-9867&vol=45&iss=&firstpage=404
18. Martinez-Mier, G and Toledo-Pereyra, L and McDuffie, J and Warner, R and Hsiao, C and Stapleton, S and Ward, P. (2002) Exogenous nitric oxide downregulates MIP-2 and MIP-1alpha chemokines and MAPK p44/42 after ischemia and reperfusion of the rat kidney J Invest Surg, 15, pp. 287-296. http://www4.infotrieve.com/newmedline/detail.asp?NameID=12396433 &Session=&searchQuery=J+Invest+Surg%5BJournal+Name%5D+ AND+15%5BVolume%5D+AND+287%5BPage+Number%5D+AND+2002%5BPublication+ Date%5D+AND+Martinez%2DMier%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0894-1939&vol=15&iss=&firstpage=287 http://dx.doi.org/10.1080%2F08941930290086083
19. Jiang, Y and Gu, X and Qiu, Y and Sun, X and (2003) Ischemic preconditioning decreases C-X-C chemokine expression and neutrophil accumulation early after liver transplantation in rats World J Gasteroenterol, 9, pp. 2025-2029. http://www.csa.com/htbin/ linkabst.cgi?issn=&vol=9&iss=&firstpage=2025
20. Winn, R and Paulson, J and Harlan, J. (1994) A monoclonal antibody to P-selectin ameliorates injury associated with hemorrhagic shock in rabbits Am J Physiol, 267, pp. H2391-2397. http://www4.infotrieve.com/newmedline/detail.asp?NameID=7528995 &Session=&searchQuery=Am+J+Physiol%5BJournal+Name%5D+AND+ 267%5BVolume%5D+AND+H2391%5BPage+Number%5D+AND+1994%5BPublication+ Date%5D+AND+Winn%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0363-6127&vol=267&iss=&firstpage=H2391
21. Garcia-Criado, F and Toledo-Pereyra, L and Lopez-Neblina, F and Phillips, M and Paez, R and Misawa, K. (1995) Role of P-selectin in total hepatic ischemia and reperfusion J Am Coll Surg, 181, pp. 327-334. http://www4.infotrieve.com/newmedline/detail.asp?NameID=7551327 &Session=&searchQuery=J+Am+Coll+Surg%5BJournal+Name%5D+ AND+181%5BVolume%5D+AND+327%5BPage+Number%5D+AND+1995%5BPublication+ Date%5D+AND+Garcia%2DCriado%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1072-7515&vol=181&iss=&firstpage=327
22. Rivera-Chavez, F and Toledo-Pereyra, L and Bachulis, B and Harkema, J and Palma-Vargas, J and Dean, R. (1997) Role of L-selectin in liver function and survival in liver function and survival in rats after uncontrolled hemorrhagic shock Surg Forum, XLVIII, pp. 103-105. http://www.csa.com/htbin/ linkabst.cgi?issn=0071-8041&vol=XLVIII&iss=&firstpage=103
23. Martinez-Mier, G and Toledo-Pereyra, L and Ward, P. (2000) Adhesion molecules in liver ischemia/reperfusion J Surg Res, 94, pp. 185-193. http://www4.infotrieve.com/newmedline/detail.asp?NameID=11104660 &Session=&searchQuery=J+Surg+Res%5BJournal+Name%5D+AND+ 94%5BVolume%5D+AND+185%5BPage+Number%5D+AND+2000%5BPublication+ Date%5D+AND+Martinez%2DMier%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-4804&vol=94&iss=&firstpage=185 http://dx.doi.org/10.1006%2Fjsre.2000.6006
24. Martinez-Mier, G and Toledo-Pereyra, L and Ward, P. (2000) P-selectin and chemokine response after liver ischemia and reperfusion J Am Coll Surg, 191, pp. 395-400. http://www4.infotrieve.com/newmedline/detail.asp?NameID=11030245 &Session=&searchQuery=J+Am+Coll+Surg%5BJournal+Name%5D+ AND+191%5BVolume%5D+AND+395%5BPage+Number%5D+AND+2000%5BPublication+ Date%5D+AND+Martinez%2DMier%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1072-7515&vol=191&iss=&firstpage=395 http://dx.doi.org/10.1016%2FS1072-7515%2800%2900360-4
25. Rivera-Chavez, F and Toledo-Pereyra, L and Nora, D and Bachulis, B and Ilgenfritz, F and Dean, R. (1998) P-selectin blockade is beneficial after uncontrolled hemorrhagic shock J Trauma, 45, pp. 404-409. http://www.csa.com/htbin/ linkabst.cgi?issn=0894-9867&vol=45&iss=&firstpage=404
26. Ramos-Kelly, J and Toledo-Pereyra, L and Jordan, J and (2000) Multiple selectin blockade with a small molecule inhibitor alters hemorrhagic SOC J Trauma, 49, pp. 92-100. http://www4.infotrieve.com/newmedline/detail.asp?NameID=10912864 &Session=&searchQuery=J+Trauma%5BJournal+Name%5D+ AND+49%5BVolume%5D+AND+92%5BPage+Number%5D+AND+2000%5BPublication+ Date%5D+AND+Ramos%2DKelly%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0894-9867&vol=49&iss=&firstpage=92
27. Kogan, T and Dupre, B and Bui, H and (1998) Novel synthetic inhibitors of selectin-mediated cell adhesion: Synthesis of 1,6-bis[3-(3-carboxymethylphenyl)-4-(2-alpha-D-mannopyranosyloxy phenyl] hexane (TBC-1269) J Med Chem, 41, pp. 1099-1111. http://www4.infotrieve.com/newmedline/detail.asp?NameID=9544210 &Session=&searchQuery=J+Med+Chem%5BJournal+Name%5D+AND+ 41%5BVolume%5D+AND+1099%5BPage+Number%5D+AND+1998%5BPublication+ Date%5D+AND+Kogan%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-2623&vol=41&iss=&firstpage=1099 http://dx.doi.org/10.1021%2Fjm9704917
28. Patel, K and Curvelier, S and Wiehler, S. (2002) Selectins: Critical mediators of leukocyte recruitment Immunology, 14, pp. 73-81. http://www.csa.com/htbin/ linkabst.cgi?issn=0953-4954&vol=14&iss=&firstpage=73
29. Nemoto, T and Burne, M and Daniels, F and O'Donnell, M and Crosson, J and Berens, K and Issekutz, A and Kasiske, B and Keane, W and Rabb, H. (2001) Small molecule selectin ligand inhibition improves outcome in ischemic acute renal failure Kidney Int, 60, pp. 2205-2214. http://www4.infotrieve.com/newmedline/detail.asp?NameID=11737594 &Session=&searchQuery=Kidney+Int%5BJournal+Name%5D+AND+ 60%5BVolume%5D+AND+2205%5BPage+Number%5D+AND+2001%5BPublication+ Date%5D+AND+Nemoto%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0098-6577&vol=60&iss=&firstpage=2205 http://dx.doi.org/10.1046%2Fj.1523-1755.2001.00054.x
30. Palma-Vargas, J and Toledo-Pereyra, L and Dean, R and (1997) Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion J Am Coll Surg, 185, pp. 365-372. http://www4.infotrieve.com/newmedline/detail.asp?NameID=9328385 &Session=&searchQuery=J+Am+Coll+Surg%5BJournal+Name%5D+ AND+185%5BVolume%5D+AND+365%5BPage+Number%5D+AND+1997%5BPublication+ Date%5D+AND+Palma%2DVargas%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1072-7515&vol=185&iss=&firstpage=365 http://dx.doi.org/10.1016%2FS1072-7515%2897%2900099-9
31. Pagliaro, P and Gattullo, D and Rastaldo, R and Losano, G. (2001) Ischemic preconditioning: From the first to the second window of protection Life Sci, 69, pp. 1-15. http://www4.infotrieve.com/newmedline/detail.asp?NameID=11411799 &Session=&searchQuery=Life+Sci%5BJournal+Name%5D+AND+ 69%5BVolume%5D+AND+1%5BPage+Number%5D+AND+2001%5BPublication+ Date%5D+AND+Pagliaro%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1069-9422&vol=69&iss=&firstpage=1 http://dx.doi.org/10.1016%2FS0024-3205%2801%2901113-4
32. Lasky, L and Presta, L and Erbe, D. (1994) Structure-function aspects of selectin-carbohydrate interactions. In Cellular Adhesion; Molecular Definition to Therapeutic Potential. (pp. 37-53). New York: Plenum Press.
33. Rosen, S and Bertozzi, C. (1994) The selectins and their ligands Curr Opin Cell Biol, 6, pp. 663-673. http://www4.infotrieve.com/newmedline/detail.asp?NameID=7530461 &Session=&searchQuery=Curr+Opin+Cell+Biol%5BJournal+Name%5D+ AND+6%5BVolume%5D+AND+663%5BPage+Number%5D+AND+1994%5BPublication+ Date%5D+AND+Rosen%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0955-0674&vol=6&iss=&firstpage=663 http://dx.doi.org/10.1016%2F0955-0674%2894%2990092-2
34. Slee, D and Romano, S and Yu, J and Nguyen, T and John, J and Raheja, N and Axe, F and Jones, T and Ripka, W. (2001) Development of potent non-carbohydrate imidazole-based small molecule selectin inhibitors with antiinflammatory activity J Med Chem, 44, pp. 2094-2107. http://www4.infotrieve.com/newmedline/detail.asp?NameID=11405647 &Session=&searchQuery=J+Med+Chem%5BJournal+Name%5D+AND+ 44%5BVolume%5D+AND+2094%5BPage+Number%5D+AND+2001%5BPublication+ Date%5D+AND+Slee%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-2623&vol=44&iss=&firstpage=2094 http://dx.doi.org/10.1021%2Fjm000508c
35. Jassen, W and Roake, J. (1998) The molecular and cellular basis of reperfusion injury following organ transplantation Transpl Rev, 12, pp. 14-33. http://www.csa.com/htbin/ linkabst.cgi?issn=0082-5948&vol=12&iss=&firstpage=14 http://dx.doi.org/10.1016%2FS0955-470X%2898%2980037-2
36. Grace, P. (1994) Ischaemia-reperfusion injury Br J Surg, 81, pp. 637-643. http://www4.infotrieve.com/newmedline/detail.asp?NameID=8044536 &Session=&searchQuery=Br+J+Surg%5BJournal+Name%5D+AND+ 81%5BVolume%5D+AND+637%5BPage+Number%5D+AND+1994%5BPublication+ Date%5D+AND+Grace%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0007-1323&vol=81&iss=&firstpage=637
37. Toledo-Pereyra, L and Rivera-Chavez, F and Dean, R. (1998) Ischemia y reperfusion hepatica, Reusltados de 21 años de investigacion Cir Gen, 20, pp. 273-283. http://www.csa.com/htbin/ linkabst.cgi?issn=&vol=20&iss=&firstpage=273
38. Harada, N and Sakamoto, S and Niwa, Y and Nakaya, Y. (2001) Involvement of adenosine in vascular contractile preconditioning Am J Physiol, 280, pp. 2911-2919. http://www.csa.com/htbin/ linkabst.cgi?issn=0363-6127&vol=280&iss=&firstpage=2911
39. Pagliaro, P and Gattullo, D and Rastaldo, R and Losano, G. (2001) Ischemic preconditioning: From the first to the second window of protection Life Sci, 69, pp. 1-15. http://www4.infotrieve.com/newmedline/detail.asp?NameID=11411799 &Session=&searchQuery=Life+Sci%5BJournal+Name%5D+AND+ 69%5BVolume%5D+AND+1%5BPage+Number%5D+AND+2001%5BPublication+Date%5D+ AND+Pagliaro%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1069-9422&vol=69&iss=&firstpage=1 http://dx.doi.org/10.1016%2FS0024-3205%2801%2901113-4
40. Lopez-Neblina, F and Paez, R and Toledo-Pereyra, L. (2001) Modulation of neutrophil infiltration through nitric oxide in the ischemic rat kidney Tranplant Proc, 27, pp. 1883-1887. http://www.csa.com/htbin/ linkabst.cgi?issn=&vol=27&iss=&firstpage=1883
41. Lopez-Neblina, F and Paez, R and Garcia-Criado, F and Misawa, K and Toledo-Pereyra, L. (1995) Exogenous nitric oxide prevents leukocyte rolling and adherence in mesenteric ischemia in the rat Cir Gen, 17, pp. 90-96. http://www.csa.com/htbin/ linkabst.cgi?issn=&vol=17&iss=&firstpage=90
42. Martinez, M and Toledo-Pereyra, L and Bussell, S and Gauvin, J and Vercruysse, G and Arab, A and Harkema, J and Jordan, J and Ward, P. (2000) Nitric oxide diminishes apoptosis and p53 gene expression after renal ischemia and reperfusion Transplantation, 70, pp. 1431-1439. http://www.csa.com/htbin/linkabst.cgi?issn=0041-1337&vol=70&iss= &firstpage=1431 http://dx.doi.org/10.1097%2F00007890-200011270-00006
43. Martinez-Mier, G and Toledo-Pereyra, L and Ward, P. (2000) Requirements of E-selectin in liver ischemia and reperfusion. Unpublished
44. Forlow, S and Ley, K. (2001) Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1 Am J Physiol Heart Circ Physiol, 280, pp. H634-H641. http://www4.infotrieve.com/newmedline/detail.asp?NameID=11158961 &Session=&searchQuery=Am+J+Physiol+Heart+Circ+Physiol%5BJournal+ Name%5D+AND+280%5BVolume%5D+AND+H634%5BPage+Number%5D+AND+ 2001%5BPublication+Date%5D+AND+Forlow%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0363-6135&vol=280&iss=&firstpage=H634
45. Smolen, J and Peterson, T and Koch, C and O'Keefe, S and Halon, W and Seo, S and Pearson, D and Fossett, M and Simon, S. (2000) L-selectin signaling of neutrophil adhesion and degranulation involves p38 mitogen-activated protein kinase J Biol Chem, 275, pp. 15876-15884. http://www4.infotrieve.com/newmedline/detail.asp?NameID=10748078 &Session=&searchQuery=J+Biol+Chem%5BJournal+Name%5D+AND+ 275%5BVolume%5D+AND+15876%5BPage+Number%5D+AND+2000%5BPublication+ Date%5D+AND+Smolen%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0884-3996&vol=275&iss=&firstpage=15876 http://dx.doi.org/10.1074%2Fjbc.M906232199
46. Brenner, B and Weinmann, S and Grassme, H and Lang, F and Linderkamp, O and Gulbins, E. (1997) L-Selectin activates JNK via src-like tyrosine kinases and the small G-protein Rac Immunology, 92, pp. 214-219. http://www4.infotrieve.com/newmedline/detail.asp?NameID=9415029 &Session=&searchQuery=Immunology%5BJournal+Name%5D+AND+ 92%5BVolume%5D+AND+214%5BPage+Number%5D+AND+1997%5BPublication+ Date%5D+AND+Brenner%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0953-4954&vol=92&iss=&firstpage=214 http://dx.doi.org/10.1046%2Fj.1365-2567.1997.00336.x
47. Junge, S and Brenner, B and Lepple-Wienhues, A and Nilius, B and Lang, F and Linderkamp, O and Gulbins, E. (1999) Intracellular mechanisms of L-selectin induced capping Cell Signal, 11, pp. 301-308. http://www4.infotrieve.com/newmedline/detail.asp?NameID=10372808 &Session=&searchQuery=Cell+Signal%5BJournal+Name%5D+AND+ 11%5BVolume%5D+AND+301%5BPage+Number%5D+AND+1999%5BPublication+ Date%5D+AND+Junge%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0898-6568&vol=11&iss=&firstpage=301 http://dx.doi.org/10.1016%2FS0898-6568%2898%2900068-0
48. Gozal, E and Simakajornboon, N and Dausman, J and (1999) Hypoxia induces selective SAPK/JNK-2-AP-1 pathway activation in the nucleus tractus solitarii of the conscious rat J Neurochem, 73, pp. 665. http://www4.infotrieve.com/newmedline/detail.asp?NameID=10428063 &Session=&searchQuery=J+Neurochem%5BJournal+Name%5D+ AND+73%5BVolume%5D+AND+665%5BPage+Number%5D+AND+1999%5BPublication+ Date%5D+AND+Gozal%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0169-5088&vol=73&iss=&firstpage=665 http://dx.doi.org/10.1046%2Fj.1471-4159.1999.0730665.x
49. Ishii, M and Suzuki, Y and Takeshita, K and Miyao, N and Kudo, H and Hiraoka, R and Nishio, K and Sato, N and Naoki, K and Aoki, T and Yamaguchi, K. (2004) Inhibition of c-Jun NH2-terminal kinase activity improves ischemia/reperfusion injury in rat lungs J Immunol, 172, pp. 2569-2577. http://www4.infotrieve.com/newmedline/detail.asp?NameID= 14764730&Session=&searchQuery=J+Immunol%5BJournal+Name%5D+ AND+172%5BVolume%5D+AND+2569%5BPage+Number%5D+AND+2004%5BPublication+ Date%5D+AND+Ishii%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0165-0378&vol=172&iss=&firstpage=2569
50. Maulik, N and Watanabe, M and Engelman, D and Engelman, R and Das, D. (1995) Oxidative stress adaptation improves postischemic ventricular recovery Mol Cell Biochem, 144, pp. 67-74. http://www4.infotrieve.com/newmedline/detail.asp?NameID=7791747 &Session=&searchQuery=Mol+Cell+Biochem%5BJournal+Name%5D+ AND+144%5BVolume%5D+AND+67%5BPage+Number%5D+AND+1995%5BPublication+ Date%5D+AND+Maulik%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0300-8177&vol=144&iss=&firstpage=67 http://dx.doi.org/10.1007%2FBF00926742
51. Maulik, N and Engelman, R and Rousou, J and (1999) Ischemic preconditioning reduces apoptosis by upregulating anti-death gene Bcl-2 Circulation, 100(Suppl.II), pp. 369-375. http://www.csa.com/htbin/linkabst.cgi?issn=0009-7322&vol=100&iss= Suppl.II&firstpage=369