Evaluation of the analgesic and anti-inflammatory effects of a Brazilian green propolis

Planta Medica

Volumn 72, Issue 10, 2006, Pages 899-906

  Paulino, Niraldo ^a   Teixeira, Cristiane ^a   Martins, Regiane ^a   Scremin, Amarilis ^a   Dirsch, Verena M ^b   Vollmar, Angelika M ^b   Abreu, Sheila R L ^c   De Castro, Solange L ^d   Marcucci, Maria Cristina ^e  

^a UNIVERSITY OF SOUTHERN SANTA CATARINA   (Brazil)

^b UNIVERSITY OF MUNICH   (Germany)

^c Nectar Pharmaceuticals   (Brazil)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

^e Universidade Bandeirante de Sao Paulo   (Brazil)

Author keywords

Analgesic effect; Anti inflammatory effect; NF B factor; Nitric oxide; Typified propolis

Indexed keywords

ALCOHOL; CAPSAICIN; CARRAGEENAN; FLAVONOID; FREUND ADJUVANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LUCIFERASE; NITRIC OXIDE; PROPOLIS; TUMOR NECROSIS FACTOR ALPHA;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN HEK293; DRUG EFFECT; DRUG MECHANISM; EDEMA; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; MACROPHAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PAW EDEMA; REPORTER GENE;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAZIL; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; MALE; MICE; NITRIC OXIDE SYNTHASE TYPE II; PAIN; PLANT EXTRACTS; PROPOLIS;

EID: 33748607437     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-947185     Document Type: Article

References (23)

1. De Castro SL. Propolis: biological and pharmacological activities. Therapeutic uses of this bee-product. Annu Rev Biol Sci 2001; 3: 49-83
2. De Campos RO, Paulino N, da Silva CH, Scremin A, Calixto JB. Anti-hyperalgesic effect of an ethanolic extract of propolis in mice and rats. J Pharm Pharmacol 1998; 50: 1187-93
3. Menezes H, Alvarez JM, Almeida E. Mouse ear edema modulation by different propolis ethanol extracts. Arzneimittelforschung 1999; 49: 705-7
4. Bankova VS, De Castro SL, Marcucci MC. Propolis: recent advances in the chemistry and plant origin. Apidologie 2000; 31: 3-15
5. Marcucci MC. Process to typing natural products. Brazilian National Institute for Intellectual Property (INPI) PI 0105471-6, 2000
6. Paulino N, Dantas AP, Bankova VS, Longhi DT, Scremin A, De Castro SL et al. Bulgarian propolis induces analgesic and anti-inflammatory effects in mice and inhibits in vitro contraction of airway smooth muscle. J Pharmacol Sci 2003; 93: 307-13
7. Marcucci MC, Ferreres F, Garcia-Viguera C, Bankova VS, De Castro SL, Dantas AP et al. Phenolic compounds from Brazilian propolis with pharmacological activities. J Ethnopharmacol 2001; 74: 105-12
8. Paulino N, Scremin FM, Raichaski LB, Marcucci MC, Scremin A, Calixto JB. Mechanisms involved in the relaxant action of the ethanolic extract of propolis in the guinea-pig trachea in vitro. J Pharm Pharmacol 2002; 54: 845-52
9. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983; 6: 109-10
10. Eddy NB, Leimback D. Synthetic analgesics. II - Dithienylbutenyl and dithienylbutylamines. J Pharmacol Exp Ther 1953; 107: 385-93
11. Calixto JB, Zanini Jr JC, Cruz AB, Yunes RA, Medeiros YS. Extract and compounds obtained from Mandevilla velutina inhibit arachidonic acid-induced ear oedema in mice, but not rat stomach contraction. Prostaglandins 1991; 41: 515-26
12. Carvalho JC, Sertie JA, Barbosa MV, Patricio KC, Caputo LR, Sarti SJ et al. Anti-inflammatory activity of the crude extract from the fruits of Pterodon emarginatus Vog. J Ethnopharmacol 1999; 64: 127-33
13. 15N] nitrate in biological fluids. Anal Biochem 1984; 126: 131-8
14. Shetty S, Brown Gladden J, Henson ES, Hu X, Villanueva J, Haney N et al. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NF-κB activation in epithelial derived cell lines. Apoptosis 2002; 7: 413-20
15. Calixto JB, Otuki MF, Santos AR. Anti-Inflammatory compounds of plant origin. Part 1. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa (NF-κB). Planta Med 2004; 69: 973-83
16. 2 and amino acids evoked by paw formalin injection: A microdialysis study in unanesthetized rats. J Neurosci 1995; 15: 2768-76
17. Doak GJ, Sawynok J. Formalin-induced nociceptive behavior and edema: Involvement of multiple peripheral 5-hydroxytryptamine receptor subtypes. Neuroscience 1997; 80: 939-49
18. Mirzoeva OK, Calder PC. The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leuk Essent Fatty Acids 1996; 55: 441-9
19. Dallegri F, Ottonello L. Tissue injury in neutrophilic inflammation. Inflamm Res 1997; 46: 382-91
20. Song YS, Park EH, Hur GM, Ryu YS, Kim YM, Jin C. Ethanol extract of propolis inhibits nitric oxide synthase gene expression and enzyme activity. J Ethnopharmacol 2002; 80: 155-61
21. Olszanecki R, Gebska A, Kozlovski VI, Gryglewski RJ. Flavonoids and nitric oxide synthase. J Physiol Pharmacol 2002; 53: 571-84
22. Rosenkranz HS, Thampatty BP. SAR: flavonoids and COX-2 inhibition. Oncol Res 2003; 13: 529-35
23. Banerjee T, VanderVliet A, Ziboh VA. Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line. Prostaglandins Leuk Essent Fatty Acids 2002; 66: 485-92