-
1
-
-
0037179653
-
Treating sepsis
-
Wenzel RP. Treating sepsis. N Engl J Med 2002; 347: 966-7.
-
(2002)
N Engl J Med
, vol.347
, pp. 966-967
-
-
Wenzel, R.P.1
-
2
-
-
0034924156
-
Epidemiology of sepsis: An update
-
Angus DC, Wax RS. Epidemiology of sepsis: an update. Crit Care Med 2001; 29: S109-S116.
-
(2001)
Crit Care Med
, vol.29
-
-
Angus, D.C.1
Wax, R.S.2
-
3
-
-
0026874127
-
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
-
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference
-
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20: 864-74.
-
(1992)
Crit Care Med
, vol.20
, pp. 864-874
-
-
-
4
-
-
0033815368
-
Pathophysiology of disseminated intravascular coagulation in sepsis
-
ten Cate H. Pathophysiology of disseminated intravascular coagulation in sepsis. Crit Care Med 2000; 28: S9-S11.
-
(2000)
Crit Care Med
, vol.28
-
-
ten Cate, H.1
-
5
-
-
0035159740
-
Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: A multicenter, randomized, placebo-controlled, single-blind, dose escalation study
-
Abraham E, Reinhart K, Svoboda P, et al. Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: a multicenter, randomized, placebo-controlled, single-blind, dose escalation study. Crit Care Med 2001; 29: 2081-9.
-
(2001)
Crit Care Med
, vol.29
, pp. 2081-2089
-
-
Abraham, E.1
Reinhart, K.2
Svoboda, P.3
-
6
-
-
1242337462
-
New treatment strategies for disseminated intravascular coagulation based on current understanding of the pathophysiology
-
Levi M, de Jonge E, van der Poll T. New treatment strategies for disseminated intravascular coagulation based on current understanding of the pathophysiology. Ann Med 2004; 36: 41-9.
-
(2004)
Ann Med
, vol.36
, pp. 41-49
-
-
Levi, M.1
de Jonge, E.2
van der Poll, T.3
-
7
-
-
1242284639
-
Coagulopathy of sepsis
-
Dempfle CE. Coagulopathy of sepsis. Thromb Haemost 2004; 91: 213-24.
-
(2004)
Thromb Haemost
, vol.91
, pp. 213-224
-
-
Dempfle, C.E.1
-
10
-
-
0029966652
-
Regulation of tissue factor gene expression in human monocytic and endothelial cells
-
Mackman N. Regulation of tissue factor gene expression in human monocytic and endothelial cells. Haemostasis 1996; 26: 17-9.
-
(1996)
Haemostasis
, vol.26
, pp. 17-19
-
-
Mackman, N.1
-
11
-
-
0036910608
-
Antithrombin: A new look at the actions of a serine protease inhibitor
-
Roemisch J, Gray E, Hoffmann IN, et al. Antithrombin: a new look at the actions of a serine protease inhibitor. Blood Coagul Fibrinolysis 2002; 13: 657-70.
-
(2002)
Blood Coagul Fibrinolysis
, vol.13
, pp. 657-670
-
-
Roemisch, J.1
Gray, E.2
Hoffmann, I.N.3
-
12
-
-
0031906776
-
Antithrombin: Its physiological importance and role in DIC
-
Mammen EF. Antithrombin: its physiological importance and role in DIC. Semin Thromb Hemost 1998; 24: 19-25.
-
(1998)
Semin Thromb Hemost
, vol.24
, pp. 19-25
-
-
Mammen, E.F.1
-
13
-
-
0021366115
-
Effects of human antithrombin III on mortality and blood coagulation induced in rabbits by endotoxin
-
Triantaphyllopoulos DC. Effects of human antithrombin III on mortality and blood coagulation induced in rabbits by endotoxin. Tbromb Haemost 1984; 51: 232-5.
-
(1984)
Tbromb Haemost
, vol.51
, pp. 232-235
-
-
Triantaphyllopoulos, D.C.1
-
14
-
-
0031950793
-
Antithrombin III in animal models of sepsis and organ failure
-
Dickneite G. Antithrombin III in animal models of sepsis and organ failure. Semin Thromb Haemost 1998; 24: 61-9.
-
(1998)
Semin Thromb Haemost
, vol.24
, pp. 61-69
-
-
Dickneite, G.1
-
15
-
-
0023084778
-
Protection against disseminated intravascular coagulation and death by antithrombin-III in the Escherichia coli endotoxemic rat
-
Emerson TE Jr, Fournel MA, Leach WJ, et al. Protection against disseminated intravascular coagulation and death by antithrombin-III in the Escherichia coli endotoxemic rat. Circ Shock 1987; 21: 1-13.
-
(1987)
Circ Shock
, vol.21
, pp. 1-13
-
-
Emerson Jr., T.E.1
Fournel, M.A.2
Leach, W.J.3
-
16
-
-
0033859376
-
Antithrombin reduces leukocyte adhesion during chronic endotoxemia by modulation of the cyclooxygenase pathway
-
Hoffmann JN, Vollmar B, Inthorn D, et al. Antithrombin reduces leukocyte adhesion during chronic endotoxemia by modulation of the cyclooxygenase pathway. Am J Physiol Cell Physiol 2000; 279: C98-C1O7.
-
(2000)
Am J Physiol Cell Physiol
, vol.279
-
-
Hoffmann, J.N.1
Vollmar, B.2
Inthorn, D.3
-
17
-
-
0141633845
-
Antithrombin modulates the leukocyte-endothelial cell interaction in the staphylococcal enterotoxin B-challenged mouse
-
Iba T, Kidokoro A, Fukunaga M, et al. Antithrombin modulates the leukocyte-endothelial cell interaction in the staphylococcal enterotoxin B-challenged mouse. J Trauma 2003; 55: 546-50.
-
(2003)
J Trauma
, vol.55
, pp. 546-550
-
-
Iba, T.1
Kidokoro, A.2
Fukunaga, M.3
-
18
-
-
0025170009
-
Heparin-like glycosaminoglycan is a receptor for antithrombiri III-dependent but not for thrombin-dependent prostacyclin production in human endothelial cells
-
Horie S, Ishii H, Kazama M. Heparin-like glycosaminoglycan is a receptor for antithrombiri III-dependent but not for thrombin-dependent prostacyclin production in human endothelial cells. Thromb Res 1990; 59: 895-904.
-
(1990)
Thromb Res
, vol.59
, pp. 895-904
-
-
Horie, S.1
Ishii, H.2
Kazama, M.3
-
19
-
-
0029781690
-
Attenuation of endotoxin-induced pulmonary vascular injury by antithrombin III
-
Uchiba M, Okajima K, Murakami K, et al. Attenuation of endotoxin-induced pulmonary vascular injury by antithrombin III. Am J Physiol 1996; 270: L921-930.
-
(1996)
Am J Physiol
, vol.270
-
-
Uchiba, M.1
Okajima, K.2
Murakami, K.3
-
20
-
-
0036155210
-
Antithrombin effects on endotoxin-induced microcirculatory disorders are mediated mainly by its interaction with microvascular endothelium
-
Hoffmann JN, Vollmar B, Romisch J, et al. Antithrombin effects on endotoxin-induced microcirculatory disorders are mediated mainly by its interaction with microvascular endothelium. Crit Care Med 2002; 30: 218-25.
-
(2002)
Crit Care Med
, vol.30
, pp. 218-225
-
-
Hoffmann, J.N.1
Vollmar, B.2
Romisch, J.3
-
21
-
-
0036339160
-
Adverse effect of heparin on antithrombin action during endotoxemia: Microhemodynamic and cellular mechanisms
-
Hoffmann JN, Vollmar B, Laschke MW, et al. Adverse effect of heparin on antithrombin action during endotoxemia: microhemodynamic and cellular mechanisms. Thromb Haemost 2002; 88: 242-52.
-
(2002)
Thromb Haemost
, vol.88
, pp. 242-252
-
-
Hoffmann, J.N.1
Vollmar, B.2
Laschke, M.W.3
-
22
-
-
0035904368
-
Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: A randomized controlled trial
-
and the KyberSept Trial Study Group
-
Warren BL, Eid A, Singer P, et al. and the KyberSept Trial Study Group. Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. J Am Med Assoc 2001; 286: 1869-78.
-
(2001)
J Am Med Assoc
, vol.286
, pp. 1869-1878
-
-
Warren, B.L.1
Eid, A.2
Singer, P.3
-
23
-
-
3242775982
-
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
-
and the Surviving Sepsis Campaign Management Guidelines Committee
-
Dellinger RP, Carlet JM, Masur H, et al. and the Surviving Sepsis Campaign Management Guidelines Committee. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32: 858-73.
-
(2004)
Crit Care Med
, vol.32
, pp. 858-873
-
-
Dellinger, R.P.1
Carlet, J.M.2
Masur, H.3
-
24
-
-
0030728147
-
A new model for quantitative in vivo microscopic analysis of thrombus formation and vascular recanalisation: The ear of the hairless (hr/hr) mouse
-
Roesken F, Ruecker M, Vollmar B, et al. A new model for quantitative in vivo microscopic analysis of thrombus formation and vascular recanalisation: The ear of the hairless (hr/hr) mouse. Thromb Haemost 1997; 78: 1408-14.
-
(1997)
Thromb Haemost
, vol.78
, pp. 1408-1414
-
-
Roesken, F.1
Ruecker, M.2
Vollmar, B.3
-
25
-
-
0026164669
-
Rapid leukocyte accumulation by "spontaneous" rolling and adhesion in the exteriorized rabbit mesentery
-
Fiebig E, Ley K, Arfors KE. Rapid leukocyte accumulation by "spontaneous" rolling and adhesion in the exteriorized rabbit mesentery. Int J Microcirc Clin Exp 1991; 10: 127-44.
-
(1991)
Int J Microcirc Clin Exp
, vol.10
, pp. 127-144
-
-
Fiebig, E.1
Ley, K.2
Arfors, K.E.3
-
26
-
-
0023373776
-
Photomodification of biological membranes with emphasis on singlet oxygen mechanisms
-
Valenzeno DR Photomodification of biological membranes with emphasis on singlet oxygen mechanisms. Photochem Photobiol 1987; 46: 147-60.
-
(1987)
Photochem Photobiol
, vol.46
, pp. 147-160
-
-
Valenzeno, D.R.1
-
27
-
-
0035822660
-
Probing inhibitor-induced conformational changes along the interface between tissue factor and factor VIIa
-
Osterlund M, Owenius R, Carlsson K, et al. Probing inhibitor-induced conformational changes along the interface between tissue factor and factor VIIa. Biochemistry 2001; 40: 9324-8.
-
(2001)
Biochemistry
, vol.40
, pp. 9324-9328
-
-
Osterlund, M.1
Owenius, R.2
Carlsson, K.3
-
28
-
-
12244256753
-
Intravascular tissuefactor pathway- a model for rapid initiation of coagulation within the blood vessel
-
Engelmann B, Luther T, Mueller I. Intravascular tissuefactor pathway- a model for rapid initiation of coagulation within the blood vessel. Thromb Haemost 2003; 89: 3-8.
-
(2003)
Thromb Haemost
, vol.89
, pp. 3-8
-
-
Engelmann, B.1
Luther, T.2
Mueller, I.3
-
29
-
-
0030221308
-
Importance of photo activation of rose bengal for platelet activation in experimental models of photochemically induced thrombosis
-
Inamo J, Belougne E, Doutremepuich C. Importance of photo activation of rose bengal for platelet activation in experimental models of photochemically induced thrombosis. Thromb, Res 1996; 83: 229-35.
-
(1996)
Thromb Res
, vol.83
, pp. 229-235
-
-
Inamo, J.1
Belougne, E.2
Doutremepuich, C.3
-
30
-
-
0031694389
-
In vivo analysis of antithrombotic effectiveness of recombinant hirudin on microvascular thrombus formation and recarialization
-
Roesken F, Vollmar B, Ruecker M, et al. In vivo analysis of antithrombotic effectiveness of recombinant hirudin on microvascular thrombus formation and recarialization. J Vasc Surg 1998; 28: 498-505.
-
(1998)
J Vasc Surg
, vol.28
, pp. 498-505
-
-
Roesken, F.1
Vollmar, B.2
Ruecker, M.3
-
31
-
-
0035052894
-
Hirudin versus heparin for anticoagulation in continuous renal replacement therapy
-
Vargas Hein O, von Heymann C, Lipps M, et al. Hirudin versus heparin for anticoagulation in continuous renal replacement therapy. Intensive Care Med 2001; 27: 673-9.
-
(2001)
Intensive Care Med
, vol.27
, pp. 673-679
-
-
Vargas Hein, O.1
von Heymann, C.2
Lipps, M.3
-
32
-
-
0035170493
-
Endogenous nitric oxide and prostaglandins synergistically counteract thromboembolism in arterioles but not in venules
-
Broeders MA, Tangelder GJ, Slaaf DW, et al. Endogenous nitric oxide and prostaglandins synergistically counteract thromboembolism in arterioles but not in venules. Arterioscler Thromb Vasc Biol 2001; 21: 163-9.
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, pp. 163-169
-
-
Broeders, M.A.1
Tangelder, G.J.2
Slaaf, D.W.3
-
33
-
-
4544331729
-
Antithrombin reduces ischemia/reperftision-induced liver injury in ratsby activation of cyclooxygenase-1
-
Harada N, Okajima K, Uchiba M, et al. Antithrombin reduces ischemia/ reperftision-induced liver injury in ratsby activation of cyclooxygenase-1. Thromb, Haemost 2004; 92: 550-8.
-
(2004)
Thromb Haemost
, vol.92
, pp. 550-558
-
-
Harada, N.1
Okajima, K.2
Uchiba, M.3
-
34
-
-
0026773307
-
Pharmacology of r-hirudin in renal impairment
-
Nowak G, Bucha E, Goock T, et al. Pharmacology of r-hirudin in renal impairment. Thromb Res 1992; 66: 707-15.
-
(1992)
Thromb Res
, vol.66
, pp. 707-715
-
-
Nowak, G.1
Bucha, E.2
Goock, T.3
-
35
-
-
0019143383
-
Clinical pharmacokinetics of heparin
-
Estes JW Clinical pharmacokinetics of heparin. Clin Pharmacokinet 1980; 5: 204-20.
-
(1980)
Clin Pharmacokinet
, vol.5
, pp. 204-220
-
-
Estes, J.W.1
-
36
-
-
0023614742
-
Antithrombin III: Biodistribution, in healthy volunteers
-
Knot EA, de Jong E, ten Cate JW, et al. Antithrombin III: biodistribution, in healthy volunteers. Thromb, Haemost 1987; 58: 1008-11.
-
(1987)
Thromb Haemost
, vol.58
, pp. 1008-1011
-
-
Knot, E.A.1
de Jong, E.2
ten Cate, J.W.3
-
37
-
-
0034092626
-
Pharmacokinetics of recombirtant tratisgenic antithrombin in volunteers
-
Lu W, Mant T, Levy JH, et al. Pharmacokinetics of recombirtant tratisgenic antithrombin in volunteers. Anesth Analg 2000; 90: 531-4.
-
(2000)
Anesth Analg
, vol.90
, pp. 531-534
-
-
Lu, W.1
Mant, T.2
Levy, J.H.3
-
38
-
-
0031803027
-
Antithrombin prevents endotoxin-induced pulmonary vascular injury by inhibiting leukocyte activation
-
Okajima K. Antithrombin prevents endotoxin-induced pulmonary vascular injury by inhibiting leukocyte activation. Blood Coagul Fibrinolysis 1998; 9 Suppl 2: S25-37.
-
(1998)
Blood Coagul Fibrinolysis
, vol.9
, Issue.SUPPL. 2
-
-
Okajima, K.1
-
39
-
-
0036493335
-
Antithrombin prevents endotoxin-induced bypotension by inhibiting the induction of nitric oxide synthase in rats
-
Isobe H, Okajima K, Uchiba M, et al. Antithrombin prevents endotoxin-induced bypotension by inhibiting the induction of nitric oxide synthase in rats. Blood 2002; 99: 1638-45.
-
(2002)
Blood
, vol.99
, pp. 1638-1645
-
-
Isobe, H.1
Okajima, K.2
Uchiba, M.3
-
40
-
-
0037944105
-
Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production
-
Mizutani A, Okajima K, Uchiba M, et al. Antithrombin reduces ischemia/ reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production. Blood 2003; 101: 3029-36.
-
(2003)
Blood
, vol.101
, pp. 3029-3036
-
-
Mizutani, A.1
Okajima, K.2
Uchiba, M.3
-
41
-
-
0034330430
-
The thrombin antagonist hirudin fails to inhibit endotoxin-induced leukocyte/endothelial cell interaction and microvascular perfusion failure
-
Hoffmann JN, Vollmar B, Inthorn D, et al. The thrombin antagonist hirudin fails to inhibit endotoxin-induced leukocyte/endothelial cell interaction and microvascular perfusion failure. Shock 2000; 5: 528-34.
-
(2000)
Shock
, vol.5
, pp. 528-534
-
-
Hoffmann, J.N.1
Vollmar, B.2
Inthorn, D.3
-
42
-
-
33646455014
-
Benefit/risk profile of high-dose antithrombin in patients with severe sepsis treated with and without concomitant heparin
-
and the KyberSept investigators
-
Hoffmann JN, Wiedermann CJ, Juers M, et al. and the KyberSept investigators. Benefit/risk profile of high-dose antithrombin in patients with severe sepsis treated with and without concomitant heparin. Thromb Haemost 2006; 95: 850-6.
-
(2006)
Thromb Haemost
, vol.95
, pp. 850-856
-
-
Hoffmann, J.N.1
Wiedermann, C.J.2
Juers, M.3
|