Altered expression of β-catenin, E-cadherin, cycloxygenase-2, and p53 protein by ovine intestinal adenocarcinoma cells

Veterinary Pathology

Volumn 43, Issue 5, 2006, Pages 613-621

  Munday, J S ^a   Brennan, M M ^a   Kiupel, M ^b  

^a MASSEY UNIVERSITY   (New Zealand)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

catenin; Animal model; Colon cancer; COX 2; E cadherin; Intestinal adenocarcinoma; p53 protein; Sheep

Indexed keywords

BETA CATENIN; CADHERIN; CYCLOOXYGENASE 2; PROTEIN P53;

ADENOCARCINOMA; ANIMAL; ARTICLE; CELL CULTURE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; INTESTINE TUMOR; METABOLISM; SHEEP; SHEEP DISEASE; SMALL INTESTINE;

ADENOCARCINOMA; ANIMALS; BETA CATENIN; CADHERINS; CELLS, CULTURED; CYCLOOXYGENASE 2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; INTESTINAL NEOPLASMS; INTESTINE, SMALL; SHEEP; SHEEP DISEASES; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; OVIS; OVIS ARIES;

EID: 33748588400     PISSN: 03009858     EISSN: 03009858     Source Type: Journal    
DOI: 10.1354/vp.43-5-613     Document Type: Article

References (40)

1. Agarwal ML, Taylor WR, Chernov MV, Chernova OB, Stark GR: The p53 network. J Biol Chem 273:1-4, 1998
2. Bondi J, Bukholm G, Nesland JM, Bukholm IR: Expression of non-membranous beta-catenin and gamma-catenin, c-Myc and cyclin D1 in relation to patient outcome in human colon adenocarcinomas. APMIS 112:49-56, 2004
3. Bright-Thomas RM, Hargest R: APC, beta-catenin and hTCF-4; an unholy trinity in the genesis of colorectal cancer. Eur J Surg Oncol 29:107-117, 2003
4. Clements WM, Lowy AM, Groden J: Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors. Clin Colorectal Cancer 3:113-120, 2003
5. Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A: Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. J Cell Biol 163:847-857, 2003
6. Cook BR: Causes of wasting in adult sheep. N Z Vet J 12:17, 1964
7. Cordes DO, Shortridge EH: Neoplasms of sheep: a survey of 256 cases recorded at Ruakura Animal Health Laboratory. NZ Vet J 19:55-64, 1971
8. Corpet DE, Pierre F: Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. Cancer Epidemiol Biomarkers Prev 12:391-400, 2003
9. Cunningham J, Lust JA, Schaid DJ, Bren GD, Carpenter HA, Rizza E, Kovach JS, Thibodeau SN: Expression of p53 and 17p allelic loss in colorectal carcinoma. Cancer Res 52:1974-1980, 1992
10. Dorudi S, Sheffield JP, Poulsom R, Northover JM, Hart IR: E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study. Am J Pathol 142:981-986, 1993
11. Fujii S, Fujimori T, Kawamata H, Takeda J, Kitajima K, Omotehara F, Kaihara T, Kusaka T, Ichikawa K, Ohkura Y, Ono Y, Imura J, Yamaoka S, Sakamoto C, Ueda Y, Chiba T: Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium. Gut 53:710-716, 2004
12. Greenlee RT, Hill-Harmon MB, Murray T, Thun M: Cancer statistics, 2001. CA Cancer J Clin 51:15-36, 2001
13. Hamilton SR, Vogelstein B, Kudo S, Riboli E, Nakamura S, Hainaut P, Rubio CA, Sobin LH, Fogt F, Winawer SJ, Goldgar DE, Jass JR: Carcinoma of the colon and rectum. In: Pathology and Genetics of Tumors of the Digestive System, ed. Hamilton SR and Aaltonen LA, pp. 104-143. IARC Press, Lyon, France, 2000
14. Hao X, Bishop AE, Wallace M, Wang H, Willcocks TC, Maclouf J, Polak JM, Knight S, Talbot IC: Early expression of cyclo-oxygenase-2 during sporadic colorectal carcinogenesis. J Pathol 187:295-301, 1999
15. Hao X, Tomlinson I, Ilyas M, Palazzo JP, Talbot IC: Reciprocity between membranous and nuclear expression of beta-catenin in colorectal tumours. Virchows Arch 431:167-172, 1997
16. Hirohashi S: Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol 153:333-339, 1998
17. Hull MA, Booth JK, Tisbury A, Scott N, Bonifer C, Markham AF, Coletta PL: Cyclooxygenase 2 is upregulated and localized to macrophages in the intestine of Min mice. Br J Cancer 79:1399-1405, 1999
18. Iacopetta B: TP53 mutation in colorectal cancer. Hum Mutat 21:271-276, 2003
19. Ilyas M, Tomlinson IP, Hanby A, Talbot IC, Bodmer WF: Allele loss, replication errors and loss of expression of E-cadherin in colorectal cancers. Gut 40:654-659, 1997
20. Kobaek-Larsen M, Thorup I, Diederichsen A, Fenger C, Hoitinga MR: Review of colorectal cancer and its metastases in rodent models: comparative aspects with those in humans. Comp Med 50:16-26, 2000
21. Liu C, Crawford JM: The Gastrointestinal Tract. In: Robins and Cotran Pathologic Basis of Disease, eds. Kumar V, Abul K, and Fausto N, 7th ed., pp. 797-875. Elsevier Saunders, Philadelphia, PA, 2005
22. McEntee MF, Brenneman KA: Dysregulation of beta-catenin is common in canine sporadic colorectal tumors. Vet Pathol 36:228-236, 1999
23. McEntee MF, Cates JM, Neilsen N: Cyclooxygenase-2 expression in spontaneous intestinal neoplasia of domestic dogs. Vet Pathol 39:428-436, 2002
24. Munday JS, Brennan MM, Jaber AM, Kiupel M: Ovine intestinal adenocarcinomas: histological and phenotypical comparison to human colon cancer. Comp Med 56:136-141, 2006
25. Munro AJ, Lain S, Lane DP: P53 abnormalities and outcomes in colorectal cancer: a systematic review. Br J Cancer 92:434-444, 2005
26. Oshima M, Taketo MM: COX selectivity and animal models for colon cancer. Curr Pharm Des 8:1021-1034, 2002
27. Sano H, Kawahito Y, Wilder RL, Hashiramoto A, Mukai S, Asai K, Kimura S, Kato H, Kondo M, Hla T: Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res 55:3785-3789, 1995
28. Shao J, Sheng H, Aramandla R, Pereira MA, Lubet RA, Hawk E, Grogan L, Kirsch IR, Washington MK, Beauchamp RD, DuBois RN: Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. Carcinogenesis 20:185-191, 1999
29. Simpson BH: The geographic distribution of carcinomas of the small intestine in New Zealand sheep. N Z Vet J 20:24-28, 1972
30. Sloncova E, Fric P, Kucerova D, Lojda Z, Tuhackova Z, Sovova V: Changes of E-cadherin and beta-catenin in human and mouse intestinal tumours. Histochem J 33:13-17, 2001
31. Sohn KJ, Puchyr M, Salomon RN, Graeme-Cook F, Fung L, Choi SW, Mason JB, Medline A, Kim YI: The effect of dietary folate on Apc and p53 mutations in the dimethylhydrazine rat model of colorectal cancer. Carcinogenesis 20:2345-2350, 1999
32. Sparks AB, Morin PJ, Vogelstein B, Kinzler KW: Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res 58:1130-1134, 1998
33. Suzui M, Okuno M, Tanaka T, Nakagama H, Moriwaki H: Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of beta-catenin mutation. Cancer Lett 183:31-41, 2002
34. Tucker E, Buda A, Janghra B, Cpoad J, Moorghan M, Havler M, Dettmar P, Pignatelli M: Abnormalities of the cadherin-catenin complex in chemically-induced colo-rectal carcinogenesis. Proc Nutr Soc 62:229-236, 2003
35. Tuynman JB, Peppelenbosch MP, Richel DJ: COX-2 inhibition as a tool to treat and prevent colorectal cancer. Crit Rev Oncol Hematol 52:81-101, 2004
36. Waddell WR, Loughry RW: Sulindac for polyposis of the colon. J Surg Oncol 24:83-87, 1983
37. Webster JD, Kiupel M, Kaneene JB, Miller R, Yuzbasiyan-Gurkan V: The use of KIT and tryptase expression patterns as prognostic tools for canine cutaneous mast cell tumors. Vet Pathol 41:371-377, 2004
38. Wolf JC, Ginn PE, Homer B, Fox LE, Kurzman ID: Immunohistochemical detection of p53 tumor suppressor gene protein in canine epithelial colorectal tumors. Vet Pathol 34:394-404, 1997
39. Wood B, Leong A: The biology and diagnostic applications of cadherins in neoplasia: a review. Pathology 35:101-105, 2003
40. Zha S, Yegnasubramanian V, Nelson WG, Isaacs WB, De Marzo AM: Cyclooxygenases in cancer: progress and perspective. Cancer Lett 215:1-20, 2004