Choosing between day 3 and day 5 embryo transfers

Clinical Obstetrics and Gynecology

Volumn 49, Issue 1, 2006, Pages 85-92

  Gardner, David K ^a   Balaban, Basak ^b  

^a National Foundation for Fertility Research   (United States)

^b AMERICAN HOSPITAL   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

BLASTOCYST; CRYOPRESERVATION; EMBRYO TRANSFER; FERTILIZATION IN VITRO; HUMAN; NONHUMAN; PREGNANCY RATE; REVIEW;

BLASTOCYST; EMBRYO IMPLANTATION; EMBRYO TRANSFER; FEMALE; HUMANS; INFERTILITY, FEMALE; PREGNANCY; PREGNANCY RATE; TIME FACTORS;

EID: 33748580377     PISSN: 00099201     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.grf.0000197501.06958.8b     Document Type: Review

References (38)

1. Gardner DK, Lane M. Towards a single embryo transfer. Reprod Biomed Online. 2003;6:470-481.
2. Huisman GJ, Alberda AT, Leerentveld RA, et al. A comparison of in vitro fertilization results after embryo transfer after 2, 3, and 4 days of embryo culture. Fertil Steril. 1994;61:970-971.
3. Scholtes MC, Zeilmaker GH. A prospective, randomized study of embryo transfer results after 3 or 5 days of embryo culture in in vitro fertilization. Fertil Steril. 1996;65:1245-1248.
4. Gardner DK, Schoolcraft WB, Wagley L, et al. A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization. Hum Reprod. 1998;13:3434-3440.
5. Milki AA, Hinckley MD, Fisch JD, et al. Comparison of blastocyst transfer with day 3 embryo transfer in similar patient populations. Fertil Steril. 2000;73:126-129.
6. Balaban B, Urman B, Alatas C, et al. Blastocyst-stage transfer of poor-quality cleavagestage embryos results in higher implantation rates. Fertil Steril. 2001;75:514-518.
7. Levitas E, Lunenfeld E, Har-Vardi I, et al. Blastocyst-stage embryo transfer in patients who failed to conceive in three or more day 2-3 embryo transfer cycles: a prospective, randomized study. Fertil Steril. 2004;81:567-571.
8. Marek D, Langley M, Gardner DK, et al. Introduction of blastocyst culture and transfer for all patients in an in vitro fertilization program. Fertil Steril. 1999;72:1035-1040.
9. Schoolcraft WB, Gardner DK. Blastocyst culture and transfer increases the efficiency of oocyte donation. Fertil Steril. 2000;74:482-486.
10. Menezo Y, Chouteau J, Veiga A. In vitro fertilization and blastocyst transfer for carriers of chromosomal translocation. Eur J Obstet Gynecol Reprod Biol. 2001;96:193-195.
11. Coskun S, Hollanders J, Al Hassan S, et al. Day 5 versus day 3 embryo transfer: a controlled randomized trial. Hum Reprod. 2000;15:1947-1952.
12. Rienzi L, Ubaldi F, Iacobelli M, et al. Day 3 embryo transfer with combined evaluation at the pronuclear and cleavage stages compares favourably with day 5 blastocyst transfer. Hum Reprod. 2002;17:1852-1855.
13. Pantos K, Athanasiou V, Stefanidis K, et al. Influence of advanced age on the blastocyst development rate and pregnancy rate in assisted reproductive technology. Fertil Steril. 1999;71:1144-1146.
14. Scholtes MC, Zeilmaker GH. Blastocyst transfer in day-5 embryo transfer depends primarily on the number of oocytes retrieved and not on age. Fertil Steril. 1998;69:78-83.
15. Balaban B, Urman B, Isiklar A, et al. Blastocyst transfer following intracytoplasmic injection of ejaculated, epididymal or testicular spermatozoa. Hum Reprod. 2001;16:125-129.
16. Karaki RZ, Samarraie SS, Younis NA, et al. Blastocyst culture and transfer: a step toward improved in vitro fertilization outcome. Fertil Steril. 2002;77:114-118.
17. Levron J, Shulman A, Bider D, et al. A prospective randomized study comparing day 3 with blastocyst-stage embryo transfer. Fertil Steril. 2002;77:1300-1301.
18. Utsunomiya T, Naitou T, Nagaki M. A prospective trial of blastocyst culture and transfer. Hum Reprod. 2002;17:1846-1851.
19. Van der Auwera I, Debrock S, Spiessens C, et al. A prospective randomized study: day 2 versus day 5 embryo transfer. Hum Reprod. 2002;17:1507-1512.
20. Frattarelli JL, Leondires MP, McKeeby JL, et al. Blastocyst transfer decreases multiple pregnancy rates in in vitro fertilization cycles: a randomized controlled trial. Fertil Steril. 2003;79:228-230.
21. Emiliani S, Delbaere A, Vannin AS, et al. Similar delivery rates in a selected group of patients, for day 2 and day 5 embryos both cultured in sequential medium: a randomized study. Hum Reprod. 2003;18:2145-2150.
22. Margreiter M, Weghofer A, Kogosowski A, et al. A prospective randomised multicenter study to evaluate the best day for embryo transer: does the outcome justify prolonged embryo culture? J Assist Reprod Genet. 2003;20:91-94.
23. Bungum M, Bungum L, Humaidan P, et al. Day 3 versus day 5 embryo transfer: a prospective randomized study. Reprod Biomed Online. 2003;7:98-104.
24. Pantos K, Makrakis E, Stavrou D, et al. Comparison of embryo transfer on day 2, day 3, and day 6: a prospective randomized study. Fertil Steril. 2004;81:454-455.
25. Hreinsson J, Rosenlund B, Fridstrom M, et al. Embryo transfer is equally effective at cleavage stage and blastocyst stage: a randomized prospective study. Eur J Obstet Gynecol Reprod Biol. 2004;117:194-200.
26. Kolibianakis EM, Zikopoulos K, Verpoest W, et al. Should we advise patients undergoing IVF to start a cycle leading to a day 3 or a day 5 transfer? Hum Reprod. 2004;19:2550-2554.
27. Papanikolaou EG, D'haeseleer E, Verheyen G, et al. Live birth rate is significantly higher after blastocyst transfer than after cleavage-stage embryo transfer when at least four embryos are available on day 3 of embryo culture. A randomized prospective study. Hum Reprod. 2005;20:3198-3203.
28. Blake D, Proctor M, Johnson N, et al. Cleavage stage versus blastocyst stage embryo transfer in assisted conception. Cochrane Database Syst Rev. 2002:CD002118.
29. Wilson M, Hartke K, Kiehl M, et al. The integration of blastocyst transfer for all patients. Fertil Steril. 2002;77:693-696.
30. Veeck L. Does the developmental stage at freeze impact on clinical results post-thaw? Reprod Biomed Online. 2003;6:367-374.
31. Anderson AR, Weikert ML, Crain JL. Determining the most optimal stage for embryo cryopreservation. Reprod Biomed Online. 2004;8:207-211.
32. Gardner DK, Surrey E, Minjarez D, et al. Single blastocyst transfer: a prospective randomized trial. Fertil Steril. 2004;81:551-555.
33. Gerris J, De Neubourg D, Mangelschots K, et al. Prevention of twin pregnancy after in-vitro fertilization or intracytoplasmic sperm injection based on strict embryo criteria: a prospective randomized clinical trial. Hum Reprod. 1999;14:2581-2587.
34. Papanikolaou EG, Camus M, Kolibianakis EM, et al. Single embryo transfer: comparison of cleavage stage embryo transfer with blastocyst stage embryo transfer. A randomized prospective study. Hum Reprod. 2005;20:i144.
35. Gerris J, De Neubourg D, Mangelschots K, et al. Elective single day 3 embryo transfer halves the twinning rate without decrease in the ongoing pregnancy rate of an IV-F/ICSI programme. Hum Reprod. 2002;17:2626-2631.
36. Hunault CC, Eijkemans MJ, Pieters MH, et al. A prediction model for selecting patients undergoing in vitro fertilization for elective single embryo transfer. Fertil Steril. 2002;77:725-732.
37. Balaban B, Urman B. Comparison of two sequential media for culturing cleavage-stage embryos and blastocysts: embryo characteristics and clinical outcome. Reprod Biomed Online. 2005;10:485-491.
38. De Sutter P, Gerris J, Dhont M. A health-economic decision-analytic model comparing double with single embryo transfer in IV-F/ICSI. Hum Reprod. 2002;17:2891-2896.