Subclinical exocrine pancreatic dysfunction resulting from decreased cholecystokinin secretion in the presence of intestinal villous atrophy

Journal of Pediatric Gastroenterology and Nutrition

Volumn 43, Issue 3, 2006, Pages 307-312

  Nousia Arvanitakis, Sanda ^a   Fotoulaki, Maria ^a   Tendzidou, Kyriaki ^a   Vassilaki, Constantina ^a   Agguridaki, Christina ^b   Karamouzis, Michael ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b AHEPA UNIVERSITY HOSPITAL   (Greece)

Author keywords

Cholecystokinin; Elastase; Enteropathy

Indexed keywords

CHOLECYSTOKININ; PANCREATIC ELASTASE;

ADOLESCENT; ADULT; ARTICLE; ATROPHY; CELIAC DISEASE; CELL STRUCTURE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENTEROPATHY; ENZYME ACTIVATION; EXOCRINE SECRETION; FECES ANALYSIS; FEMALE; GASTROINTESTINAL DISEASE; GLUTEN FREE DIET; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTESTINE BIOPSY; INTESTINE INJURY; INTESTINE MUCOSA; INTESTINE VILLUS; MALE; PANCREAS INSUFFICIENCY; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN SECRETION;

ADOLESCENT; ATROPHY; BIOPSY; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; CHOLECYSTOKININ; DIETARY FATS; FECES; FEMALE; HUMANS; INFANT; INTESTINAL MUCOSA; INTESTINES; MALE; MILK HYPERSENSITIVITY; MILK PROTEINS; PANCREAS; PANCREATIC ELASTASE; SINCALIDE;

EID: 33748567438     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpg.0000228098.66583.85     Document Type: Article

References (20)

1. Jensen TR. Involvement of cholecystokinin/gastrin-related peptides and their receptors in clinical gastrointestinal disorders. Pharmacol Toxicol 2002;91:333-50.
2. DiMagno EP, Go VLW, Summerskill WHJ. Impaired cholecystokinin pancreozymin secretion, intraluminal dilution and maldigestion of fat in sprue. Gastroenterology 1972;63:25-32.
3. Bloom SR, Pollack JM, Besterman HS. Gut hormone profile in celiac disease: a characteristic pattern of pathology. In: McNicholl B, McCarthy CF, Fottrell PF eds. Perspectives in Celiac Disease. Lancaster, UK: MTP Press, 1978:399-11.
4. Besterman HS, Bloom SP, Sarson DL, et al. Gut hormone profile in celiac disease. Lancet 1978;1:785-8.
5. Carrocio A, Iacono G, Montalto G, et al. Exocrine pancreatic function in children with celiac disease before and after a gluten free diet. Gut 1991;32:796-9.
6. Carroccio A, Iacono G, Lerro P, et al. Role of pancreatic impairment in growth recovery during gluten-free diet in childhood celiac disease. Gastroenterology 1997;112:1839.
7. Nousia-Arvanitakis S, Karagiozoglou-Lampoudes T, Aggouridaki C, et al. Influence of jejunal morphology changes on exocrine pancreatic function in celiac disease. J Pediatr Gastroenterol Nutr 1999;29:81-5.
8. Walkowiak J, Herzig KH. Fecal elastase-1 is decreased in villous atrophy regardless of underlying disease. Eur J Clin Invest 2001;31:425-30.
9. Salvatore S, Finazzi S, Barassi A, et al. Low fecal elastase: potentially related to transient small bowel damage resulting from enteric pathogens. J Pediatr Gastroenterol Nutr 2003;36:392-6.
10. Marsh NM. Gluten, major histocompatility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity. Gastroenterology 1992;102:330-54.
11. Calam J, Ellis A, Dockray J. Identification and measurement of molecular variants of cholecystokinin in duodenal mucosa and plasma. Diminished concentrations in patients with celiac disease. J Clin Invest 1982;69:218-25.
12. Pollack JM, Blood SR, McCrossan MV, et al. Cholecystokinin abnormalities in celiac disease. Gastroenterology 1978;74:1079. [abstract].
13. Hopman WPM, Rosenbusch G, Hectors MPC, et al. Effect of predigested fat on intestinal stimulation of plasma cholecystokinin and gall bladder motility in celiac disease. Gut 1995;36:17-21.
14. Winter TA, Lemmer ER, O'Keefe SJ, et al. The effect of severe undernutrition, and subsequent refeeding on digestive function in human patients. Eur J Gastroenterol Hepatol 2000;12:191-6.
15. Winter TA, Marks T, Callanan M, et al. Impaired pancreatic secretion in severely malnourished patients is a consequence of primary pancreatic dysfunction. Nutrition 2001;17:230-5.
16. Loser C, Mollgard A, Folsch UR. Fecal elastase 1: a novel, highly sensitive, and specific tubeless pancreatic function test. Gut 1996;39:580-6.
17. Soldan W, Henker J, Sprossig C. Sensitivity and specificity of quantitative determination of pancreatic elastase 1 in feces of children. J Pediatr Gastroenterol Nutr 1997;24:53-5.
18. Nousia-Arvanitakis S. Fecal elastase-1 concentration: an indirect test of exocrine pancreatic function and a marker of an enteropathy regardless of cause. J Pediatr Gastroenterol Nutr 2003;36:314-5.
19. Walkowiak J, Nousia-Arvanitakis S, Henker J, et al. Indirect pancreatic function tests in Children. J Pediatr Gastroenterol Nutr 2005;40:107-14.
20. Stein J, Jung M, Sziegoleit A, et al. Immunoreactive elastase 1: clinical evaluation of a new noninvasive test of pancreatic function. Clin Chem 1996;42:222-6.