Detection of colchicine by means of LC-MS/MS after mistaking meadow saffron for bear's garlic

Forensic Science, Medicine, and Pathology

Volumn 2, Issue 3, 2006, Pages 193-198

  Wehner, Frank ^a,d   Mußhoff, Frank ^b   Schulz, Martin M ^a   Martin, David D ^c   Wehner, Heinz Dieter ^a  

^a Institute of Legal Medicine   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c University Children's Clinic   (Germany)

^d Institute for Legal Medicine Tübingen   (Germany)

Author keywords

Bear's garlic (Allium ursinum); Colchicine; Forensic toxicology; LC MS MS; Meadow saffron (Colchicum autumnale); Poisoning

Indexed keywords

EID: 33748564032     PISSN: 1547769X     EISSN: None     Source Type: Journal    
DOI: 10.1385/FSMP:2:3:193     Document Type: Article

References (22)

1. Sundov Z, Nincevic Z, Definis-Gojanovic M, et al. Fatal colchicines poisoning by accidental ingestion of meadow saffron-case report. Forensic Sci Int 2000:149:253-256.
2. Sannohe S, Makino Y. Kita T. Kuroda N, Shinozuka T. Colchicine poisoning resulting from accidental ingestion of meadow saffron (Colchicum autumnalc). J Forensic Sci 2002;47:1391-1396.
3. Kauert G, MeyerVL. Drascg G. Tödliche Vergiftung nach Genuß von Colchicumblattsalat. In: Eisenmenger R, S chuck M, Eds. Festschrift, für Wolfgang Spann. Berlin: Springer, 1986.
4. Sussman JS, Brozena SC, Skopp N, Korecka M, Shaw LM. Accidental intravenous colchicine poisoning. Ther Drug Mon 2004:26:688-692.
5. Hobson CH, Rankin APN. A fatal colchicines overdose. Anaest Int Care 1986;14:453-464.
6. Dominguez de Villota E, Galdos P, Mosquera JM, Tomas MI. Colchicine overdose: An unsusual origin of mulliorgan failure. Crit Care Med 1979;7:278-279.
7. Caplan YH. Orloff KG, Thomson BC. A fatal overdose with colchicines. J Anal Tox 1980:4:153-155.
8. Dehon B. Chagnon JL, Vinner E, Pommery J, Mathieu D. Lhermitte M. Colchicine poisoning: report of a fatal case with body fluid and post-mortem tissue analysis by high-performance liquid chromatography. Biomed Chrom 1999;13:235-238.
9. Allender WJ. Colchicine poisoning as a mode of suicide. J Forensic Sci 1982:27:944-947.
10. Weakley-Jones B. Gerber JE, biggs G. Colchicine poisoning: case report of two homicides. Am J Forensic Med Pathol 2001;22:203-206.
11. Rieder CL, Palazzo RE. Colcemid and the milolic cycle. J Cell Sci 1992; 102:196-211.
12. Stapczynski JS, Rothstein RJ. Gaye WA. Niemann JT. Colchicine overdose: report of two cases and review of the literature. Ann Emerg Med 1981; 10:364-369.
13. McLeod J, Phillips L. Hypersensitivity and to colchicines. Am. J Rheumat Dis 1947:6:224-229.
14. Gilbert JD, Byard RW. Epithelial cell mitotic arrest - a useful postmortem histologic marker in cases of possible colchicines toxicily. Forensic Sci Int 2002;126:150-152.
15. Byard RW, Stockham PC, Gilbert JD. Vomiting, diarrhea, and sudden death with recent southeast asian travel: fatal colchicine toxicity. For Sci Med Path 2005:1:149-152.
16. Klintschar M, Beham-Schmidt Ch, Radner H, henning G, Roll P. Colchicine poisoning by accidental ingestion of meadow saffron (Colchicum autumnale): pathological and medicolegal aspects. Forensic Sci Int 1999;106:191-200.
17. Clevenger CV, August TF, Shaw LM. Colchicine poisoning: Report of a fatal case with body fluid analysis by GC/MS and histopathologic examination of postmortem tissues. J Anal Tox 1991;15:151-154.
18. McIntyre IM, Ruskiewicz AR, crump AR, Drummer OH. Death following colchicines poisoning. J Forensic Sci 1994;39: 280-286.
19. Deveaux M, hubert N, Demaiiy C. Colchicine poisoning: case report, of two suicides. Forensic Sci Int. 2004;143:219-222.
20. Kinz, P, Jamey C, Tracqui A, Mangin P. Colchicine poisoning: report of a fatal ease and presentation of an HPLC procedure for body fluid and tissue analyses. J Anal Tox 1997:21:70-72.
21. Jones GR, Singer PP, Bannach B. Application of LC-MS analysis to a fatal colchicine fatality. J Anal Tox 2002:26:365-369.
22. Schemnann JM, Terrien N, Urtizberea M, Pierson P, Denis H, Bourre JM. Immunotoxicotherapy: present, status and future trends. J Toxicol Clin Toxicol 1989:27:1-35.