Etrurians vs Greeks: May ACE I/D polymorphism still be considered as a marker of susceptibility of SSc?

Clinical and Experimental Rheumatology

Volumn 24, Issue 4, 2006, Pages 432-434

  Guiducci, Serena ^a   Fatini, Cinzia ^a   Georgountzos, Athanassios ^b   Sticchi, Elena ^a   Cinelli, Marina ^a   Kaloudi, Olga ^a   Rogai, Veronica ^a   Melchiorre, Daniela ^a   Pignone, Alberto ^a   Vlachoyannopoulos, Panayiotis ^b   Abbate, Rosanna ^a   Matucci Cerinic, Marco ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

ACE I D polymorphism systemic sclerosis; Genetic background

Indexed keywords

BIOCHEMICAL MARKER; DIPEPTIDYL CARBOXYPEPTIDASE;

ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ETHNIC DIFFERENCE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; GREECE; HUMAN; HUMAN CELL; ITALY; MAJOR CLINICAL STUDY; POPULATION GENETICS; PREVALENCE; PRIORITY JOURNAL; SOUTHERN EUROPE; SYSTEMIC SCLEROSIS;

AMINO ACID SUBSTITUTION; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; GENOTYPE; GREECE; HUMANS; ITALY; MALE; MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC; SCLERODERMA, SYSTEMIC;

EID: 33748557451     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. LEROY EC: Systemic sclerosis: a vascular perspective. Rheum Dise Clin N Am 1996; 22: 675-95
2. MATUCCI CERINIC M, G FIORI GRENBAUM E, SHOENFELD Y: Macrovascular disease in systemic sclerosis. In: Systemic sclerosis, eds: D FURST e P CLEMENTS 2003; 241-8
3. KAHALEH MB: Vascular involvement in systemic sclerosis (SSc). Clin Exp Rheumatol 2004; 22 (Suppl. 33): S19-23.
4. RIGAT B, HUBERT C, CORVOL P SOUBRIER F: PCR detection of the insertion/ deletion polymorphism of the human angiotensin converting enzyme gene (DCPI) (dipeptidyl carboxypeptidase 1). Nucl Acids Res 1992; 20: 1433.
5. RIGAT B, HUBERT C, ALHENC-GELAS F, CAMBIEN F, CORVOL P SOUBRIER F: An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343-6.
6. HAMDI HK, CASTELLON R: A genetic variant of ACE increases cell survival: a new paradigm for biology and disease. Biochem Biophys Res Commun 2004; 318: 187-91.
7. SUEHIRO T, MORITA T, INOUE M, KUMON Y, IKEDA Y, HASHIMOTO K: Increased amount of the angiotensin-converting enzyme (ACE) mRNA originating from the ACE allele with deletion. Hum Genet 2004; 115: 91-6.
8. FATINI C, GENSINI F, STICCHI E et al.: High prevalence of polymorphisms of angiotensin-converting enzyme (I/D) and endothelial nitric oxide synthase (GIu298Asp) in patients with systemic sclerosis. Am J Med 2002; 112: 540-4.
9. MAYER NJ, FORSYTH A, KANTACHUVESIRI S, MULLINS JJ, FLEMING S: Association of the D allele of the angiotensin I converting enzyme polymarphism with malignant vascular injury. J Clin Pathol:Mol Pathol 2002; 55: 29-33.
10. ASSASSI S, TERCERO GM, REVEILLE JD et al.: Polymorphism of the endothelial nitric oxide synthase and angiotensin converting enzyme show no association with systemic sclerosis. Arthritis Rheum 2003; 48 (Suppl.): 313.
11. JOUNG C, KIM S, YUN B et al.: Association of HLA DR1, angiotensin converting enzyme insertion/deletion gene polymorphism with clinical features of systemic sclerosis in Korea. Arthritis Rheum 2003; 48 (Suppl.): 316.
12. ANGOTTI C, BARTOLI F, RIGHI A et al.: Polymorphisms of ACE (I/D) and macrovascular disease in systemic sclerosis. (submitted).
13. STAESSEN JA, GINOCCHIO G, WANG JG et al.: Genetic variability in the renin-angiotensin system: prevalence of alleles and genotypes. J Cardiovasc Risk 1997; 4: 401-22.
14. FATINI C, GUIDUCCI S, ABBATE R, MATUCCI CERINIC M: Vascular injury in Systemic Sclerosis: angiotensin-converting enzyme Insertion/Deletion polymorphism. Curr Rheum Rep 2004; 6: 149-55.
15. KEAVNEY B, McKENZIE C, PARISH S et al.: Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/ deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies on Infarct Survival (ISIS) Collaborators. Lancet 2000; 5: 355, 434-42.