The epithelial cell rests of Malassez - A role in periodontal regeneration?

Journal of Periodontal Research

Volumn 41, Issue 4, 2006, Pages 245-252

  Rincon, J C ^a   Young, W G ^a   Bartold, P M ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Embryology; Epithelial cell rests of Malassez; Periodontal regeneration; Review

Indexed keywords

KERATIN; MEMBRANE PROTEIN; SCLEROPROTEIN;

ANIMAL; BIOSYNTHESIS; CYTOLOGY; EPITHELIUM CELL; HUMAN; METABOLISM; PERIODONTAL LIGAMENT; PHYSIOLOGY; PRENATAL DEVELOPMENT; REGENERATION; REVIEW; TOOTH ROOT;

ANIMALS; EPITHELIAL CELLS; EXTRACELLULAR MATRIX PROTEINS; HUMANS; KERATINS; MEMBRANE PROTEINS; PERIODONTAL LIGAMENT; REGENERATION; TOOTH ROOT;

EID: 33748543627     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2006.00880.x     Document Type: Review

References (95)

1. Serres A. Essai sur L'anatomie et la physiologie den dents ou nouvelle théorie de la dentition. Mequignon-Marvis, Paris. 1817;28.
2. Malassez L. Sur l'existence damas epitheliaux autour de la racine des dents chez l'homme adulte et a l'etat normal (debris epitheliaux paradentaires). Arch Physiol 1885l5:129-148.
3. Mummary JH. Studies and Dental Histology II. The Sheath of Hertwig and the Epithelial Debris. Dental Cosmos 1921;63:1207-1215.
4. Noyes FB, Thomas NG. Dental Histology and Emhriology. Philadelphia: Lea & Febiger, 1921.
5. Orban B. Ist das 'Paradentium' eine 'or- ganische Einheit'. Stomat 1926;24:515-525.
6. Orban B. The epithelial network in the periodontal membrane. J Am Dent Assoc 1952;44:632-625.
7. Reeve C, Wentz F. Epithelial rests in the periodontal ligament. Oral Surg Oral Med Oral Pathol 1962;15:785-793.
8. Reitan K. Behaviour of Malassez epithelial rests during orthodontic tooth movement. Acta Odontol Scand 1961;19:443-468.
9. Wentz FM, Weinmann JP, Schour I. The prevalence, distribution and morphologic changes of the epithelial remnants in the molar region of the rat. J Dent Res 1950;29:3-12.
10. Ten Gate AR. The epithelial cell rests of Malassez and the genesis of the dental cyst. Oral Surg Oral Med Oral Pathol 1972;34:956-964.
11. Black GV. The fibers and glands of the peridental membrane. Dental Cosmos 1899;41:101-122.
12. Simpson HE. The degeneration of the rests of Malassez with age as observed by the Apoxestic Technique. J Periodontol 1965;36:28-31.
13. Spouge JD. The rests of Malassez and chronic marginal periodontitis. J Clin Periodontol 1984;11:340-347.
14. Diekwisch TO. The developmental biology of cementum. Int J Dev Biol 2001;45:695-706.
15. Spouge JD. A new look at the rests of Malassez. A review of their embryological origin, anatomy, and possible role in periodontal health and disease. J Periodontol 1980;51:437-444.
16. Spouge JD. Rests of Malassez and chronic marginal periodontal disease. J Can Dent Assoc 1980;46:712-716.
17. Thurley DC. Development, growth and eruption of permanent incisor teeth in Romney sheep. Res Vet Sci 1985;39:127-138.
18. Grant DB, Bernic S. A possible continuity between epithelial rests and epithelial attachment in miniature swine. J Periodant 1969;40:23-31.
19. Spouge JD. A study of epithelial odontogenic residues in the pig. J Periodontol 1986;57:164-171.
20. Valderhaug J, Zander HA. Relationship of 'epithelial rests of Malassez' to other periodontal structures. Periodontics 1967;5:254-258.
21. Valderhaug JP, Nylen MU. Function of epithelial rests as suggested by their ultrastructure. J Periodant Res 1966;1:69-78.
22. Hamamoto Y, Nakajima T, Ozawa H. Ultrastructure of epithelial rests of Malassez in human periodontal ligament. Arch Oral Biol 1989;34:179-185.
23. Birek C, Aubin JE, Bhargava U, Brunette DM, Melcher AH. Dome formation by oral epithelia in vitro. In Vitro 1982;18:382-392.
24. Birek P, Wang HM, Brunette DM, Melcher AH. Epithelial rests of Malassez in vitro. Phagocytosis of collagen and the possible role of their lysosomal enzymes in collagen degradation. Lab Invest 1980;43:61-72.
25. Brunette DM. Mechanical stretching increases the number of epithelial cells synthesizing DNA in culture. J Cell Sci 1984;69:35-45.
26. Kanoza RJ, Brunette DM, Purdon AD, Sodek J. Isolation and identification of epithelial-like cells in culture by a collagenase-separation technique. In Vitro 1978;14:746-753.
27. Hamamoto Y, Nakajima T, Ozawa H. Ultrastructural and histochemical study on the morphogenesis of epithelial rests of Malassez. Arch Histol Cytol 1989;52:61-70.
28. Hamamoto Y, Suzuki I, Nakajima T, Ozawa H. Immunocytochemical localization of laminin in the epithelial rests of Malassez of immature rat molars. Arch Oral Biol 1991;36:623-626.
29. Yamasaki A, Pinero GJ. An ultrastructural study of human epithelial rests of Malassez maintained in a differentiated state in vitro. Arch Oral Biol 1989;34:443-451.
30. Beertsen W, Everts V. Autodesmosomes in epithelial cells of rests of Malassez in the incisor and molar periodontal ligament of the mouse. Arch Oral Biol 1979;24:239-241.
31. Wesselink PR, Beertsen W. The prevalence and distribution of rests of Malassez in the mouse molar and their possible role in repair and maintenance of the periodontal ligament. Arch Oral Biol 1993;38:399-403.
32. Berkovitz BK, Whatling R, Barrett AW, Omar SS. The structure of bovine periodontal ligament with special reference to the epithelial cell rests. J Periodontol 1997;68:905-913.
33. Lambrichts I, Creemers J, Van Steenberghe D. Periodontal neural endings intimately relate to epithelial rests of Malassez in humans. A light and electron microscope study. J Anat 1993;182:153-162.
34. Brice GL, Sampson WJ, Sims MR. An ultrastructural evaluation of the relationship between epithelial rests of Malassez and orthodontic root resorption and repair in man. Aust Orthod J 1991;12:90-94.
35. Peters BH, Peters JM, Kuhn C, Zoller J, Franke WW. Maintenance of cell-type-specific cytoskeletal character in epithelial cells out of epithelial context, cytokeratins and other cytoskeletal proteins in the rests of Malassez of the periodontal ligament. Differentiation 1995;59:113-126.
36. Gao Z, Mackenzie IC, Williams DM, Cruchley AT, Leigh I, Lane EB. Patterns of keratin-expression in rests of Malassez and periapical lesions. J Oral Pathol 1988;17:178-185.
37. Gao Z, Mackenzie IC, Pan S, Shi J. Epithelial lining of sinus tracts associated with periapical disease: an immunocyto-chemical study using monoclonal anti bodies to keratins. J Oral Pathol Med 1991;20:228-233.
38. Sculean A, Lioubavina N, Theilade J, Karring T. Absence of Malassez epithelial rests in the regenerated periodontal ligament. A pilot study in the monkey. J Periodont Res 1998;33:310-314.
39. Fong CD, Hammarstrom L. Expression of amelin and amelogenin in epithelial root sheath remnants of fully formed rat molars. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:218-223.
40. Sculean A, Berakdar M, Pahl S et al. Patterns of cytokeratin expression in monkey and human periodontium following regenerative and conventional periodontal surgery. J Periodont Res 2001;36:260-268.
41. Uitto VJ, Larjava H, Peltonen J, Brunette DM. Expression of fibronectin and integrins in cultured periodontal ligament epithelial cells. J Dent Res 1992;71:1203-1211.
42. Rincon JC, Xiao Y, Young WG, Bartold PM. Production of osteopontin by cultured porcine epithelial cell rests of Malassez. J Periodont Res 2005;40:417-426.
43. Kat PS, Sampson WJ, Wilson DF, Wiebkin OW. Distribution of the epithelial rests of Malassez and their relationship to blood vessels of the periodontal ligament during rat tooth development. Aust Orthod J 2003;19:77-86.
44. Heyeraas KJ, Kvinnsland I, Byers MR, Jacobsen EB. Nerve fibers immunoreactive to protein gene product 9.5, calcitonin gene-related peptide, substance P, and neuropeptide Y in the dental pulp, periodontal ligament, and gingiva in cats. Acta Odontol Scand 1993;31:207-221.
45. Kvinnsland IH, Tadokoro O, Heyeraas KJ, Kozawa Y, Vandevska-Radunovic V. Neuroendocrine cells in Malassez epithelium and gingiva of the cat. Acta Odontol Scand 2000;58:107-112.
46. Tadokoro O, Maeda T, Heyeraas KJ, Vandevska-Radunovic V, Kozawa Y, Hals Kvinnsland I. Merkel-like cells in Malassez epithelium in the periodontal ligament of cats: an immunohistochemical, confocal-laser scanning and immuno electron-microscopic investigation. J Periodont Res 2002;37:456-463.
47. Woodnutt DA. Byers MR. Morphological variation in the tyrosine receptor kinase A- immunoreactive periodontal ligament epithelium of developing and mature rats. Arch Oral Biol 2001;46:163-171.
48. Yamashiro T, Fujiyama K, Fukunaga T, Wang Y, Takano-Yamamoto T. Epithelial rests of Malassez express immunore-activity of TrkA and its distribution is regulated by sensory nerve innervation. J Histochem Cytochem 2000;8:979-984.
49. Beck F, Tucci J, Russell A, Senior PV, Ferguson MW. The expression of the gene coding for parathyroid hormone-related protein (PTHrP) during tooth development in the rat. Cell Tissue Res 1995;280:283-290.
50. Hamamoto Y, Nakajima T, Ozawa H, Uchida T. Production of amelogenin by enamel epithelium of Hertwig's root sheath. Oral Surg Oral Med Oral Pathol Oral Radial Endod 1996;81:703-709.
51. Yoshiba N, Yoshiba K, Aberdam D et al. Expression and localization of laminin-5 subunits in the mouse incisor. Cell Tissue Res 1988;292:143-149.
52. Merrilees MJ, Sodek J, Aubin JE. Effects of cells of epithelial rests of Malassez and endothelial cells on synthesis of glycos-aminoglycans by periodontal ligament fibroblasts in vitro. Dev Biol 1983;97:146-153.
53. Abiko Y, Saitoh M, Inoue T. Shimono M. Kaku T. Laminin localization and gelatinolytic activity of epithelial rest of Malassez grown on titanium. Bull Tokyo Dent Coll 1994;35:55-59.
54. Mouri Y, Shiba H, Mizuno N, Noguchi T, Ogawa T, Kurihara H. Differential gene expression of bone-related proteins in epithelial and fibroblastic cells derived from human periodontal ligament. Cell Biol Int 2003;27:519-524.
55. Hasegawa N, Kawaguchi H, Ogawa T, Uchida T, Kurihara H. Immunohisto-chemical characteristics of epithelial cell rests of Malassez during cementum repair. J Periodont Res 2003;38:51-56.
56. Rincon JC, Xiao Y, Young WG, Bartold PM. Enhanced proliferation, attachment and osteopontin expression of porcine periodontal cells with Emdogain. Arch Oral Biol 2005;50:1047-1054.
57. Mizuno N, Shiba H, Mouri Y et al. Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone related and enamel proteins. Cell Biol Int 2005;29:111-117.
58. Brunette DM, Heersche JN, Purdon AD, Sodek J, Moe HK, Assuras JN. In-vitro cultural parameters and protein and prostaglandin secretion of epithelial cells derived from porcine rests of Malassez. Arch Oral Biol 1979;24:199-203.
59. Liu F, Abiko Y, Nishimura M, Kusano K, Shi S, Kaku T. Expression of inflammatory cytokines and beta-defensin 1 mRNAs in porcine epithelial rests of Malassez in vitro. Med Electron Microsc 2001;34:174-178.
60. Onishi T, Ooshima T, Sobue S et al. Immunohistochemical localization of calbindin D28k during root formation of rat molar teeth. Cell Tissue Res 1999;297:503-512.
61. Guajardo G, Okamoto Y, Gogen H et al. Immunohistochemical localization of epidermal growth factor in cat paradental tissues during tooth movement. Am J Orthod Dentofacial Orthop 2000;118:210-219.
62. Lin LM, Wang SL, Wu-Wang C, Chang KM, Leung C. Detection of epidermal growth factor receptor in inflammatory periapical lesions. Int Endod J 1996;29:179-184.
63. Nordlund L, Hormia M, Saxen L, Thesleff I. Immunohistochemical localization of epidermal growth factor receptors in human gingival epithelia. J Periodont Res 1991;26:333-338.
64. Thesleff I. Epithelial cell rests of Malassez bind epidermal growth factor intensely. J Periodont Res 1987;22:419-421.
65. Salonen J, Uitto VJ, Pan YM, Oda D. Proliferating oral epithelial cells in culture are capable of both extracellular and intracellular degradation of interstitial collagen. Matrix 1991;11:43-55.
66. Uitto VJ, Airola K, Vaalamo M et al. Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation. Am J Pathol 1998;152:1489-1499.
67. Firth JD, Putnins EE, Larjava H, Uitto VJ. Bacterial phospholipase C upregulates matrix metalloproteinase expression by cultured epithelial cells. Infect Immun 1997;65:4931-4936.
68. Nip LH, Uitto VJ, Golub LM. Inhibition of epithelial cell matrix metalloproteinases by tetracyclines. J Periodont Res 1993;28:379-385.
69. Firth JD, Sue ES, Putnins EE, Oda D, Uitto VJ. Chymotrypsin-like enzyme secretion is stimulated in cultured epithelial cells during proliferation and in response to Actinohacillus actinomycetemcomitans. J Periodont Res 1996;31:345-354.
70. Cochran DL, Wozney JM. Biological mediators for periodontal regeneration. Periodontol 2000 1999;19:40-58.
71. Egelberg J. Regeneration and repair of periodontal tissues. J Periodont Res 1987;22:233-242.
72. Melcher AH. On the repair potential of periodontal tissues. J Periodontol 1976;47:256-260.
73. Meyer JR. The regenerative potential of the periodontal ligament. J Prosthet Dent 1986;55:260-265.
74. Pitaru S, McCulloch CA, Narayanan SA. Cellular origins and differentiation control mechanisms during periodontal development and wound healing. J Periodont Res 1994;29:81-94.
75. Bartold PM, Narayanan AS. Biology of Periodontal Connective Tissues. Chicago: Quintessence Publishing, 1998.
76. MacNeil RL, Berry JE, Strayhorn CL, Shigeyama Y, Somerman MJ. Expression of type I and XII collagen during development of the periodontal ligament in the mouse. Arch Oral Biol 1998;43:779-787.
77. Macneil RL, Sheng N, Strayhorn C, Fisher LW, Somerman MJ. Bone sialoprotein is localized to the root surface during cementogenesis. J Bone Miner Res 1994;9:1597-1606.
78. MacNeil RL, Berry J, D'Errico J, Strayhorn C, Piotrowski B, Somerman MJ. Role of two mineral-associated adhesion molecules, osteopontin and bone sialo-protein, during cementogenesis. Connect Tissue Res 1995;33:1-7.
79. McKee MD, Nanci A. Osteopontin at mineralized tissue interfaces in bone, teeth, and osseointegrated implants: ultrastructural distribution and implications for mineralized tissue formation, turnover, and repair. Microsc Res Tech 1996;33:141-164.
80. Bosshardt DD, Nanci A. Hertwig's epithelial root sheath, enamel matrix proteins, and initiation of cementogenesis in porcine teeth. J Clin Periodontol 2004;31:184-192.
81. Bosshardt DD, Selvig KA. Dental cementum: the dynamic tissue covering of the root. Periodontol 2000 1997;13:41-75.
82. Bosshardt DD. Zalzal S, McKee MD, Nanci A. Developmental appearance and distribution of bone sialoprotein and osteopontin in human and rat cementum. Anat Rec 1998;250:13-33.
83. Lekic P, Sodek J, McCulloch CA. Osteopontin and bone sialoprotein expression in regenerating rat periodontal ligament and alveolar bone. Anat Rec 1996;244:50-58.
84. Ivanovski S, Li H, Haase HR, Bartold PM. Expression of bone associated macromolecules by gingival and periodontal ligament fibroblasts. J Periodont Res 2001;36:131-141.
85. Giachelli CM, Liaw L, Murry CE, Schwartz SM, Almeida M. Osteopontin expression in cardiovascular diseases. Ann NY Acad Sci 1995;760:109-126.
86. Hunter OK, Goldberg HA. Modulation of crystal formation by bone phosphoproteins: role of glutamic acid-rich sequences in the nucleation of hydroxyapatite by bone sialoprotein. Biochem J 1994;302:175-179.
87. Denhardt DT, Lopez CA, Rollo EE, Hwang SM, An XR, Walther SE. Osteopontin-induced modifications of cellular functions. Ann N Y Acad Sci 1995;760:127-142.
88. Feng B, Rollo EE, Denhardt DT. Osteopontin (OPN) may facilitate metastasis by protecting cells from macrophage NO-mediated cytotoxicity: evidence from cell lines down-regulated for OPN expression by a targeted ribozyme. Clin Exp Metastasis 1995;13:453-462.
89. Hunter GK, Kyle CL, Goldberg HA. Modulation of crystal formation by bone phosphoproteins: structural specificity of the osteopontin-mediated inhibition of hydroxyapatite formation. Biochem J 1994;300:723-728.
90. Saygin NE, Giannobile WV, Somerman MJ. Molecular and cell biology of cementum. Perlodontol 2000 2000;24:73-98.
91. Löe H, Waerhaug J. Experimental replantation of teeth in dogs and monkeys. Arch Oral Biol 1961;3:176-184.
92. Inoue T, Enokiya Y, Hashimoto S, Fukumashi K, Shimono M. Homeostatic factors in periodontal ligament after wound healing. Effects of Malassezis epithelial rests. Jpn J Oral Biol 1993;37:58-69.
93. Shimono M, Ishikawa T, Ishikawa H et al. Regulatory mechanisms of periodontal regeneration. Microsc Res Tech 2003;60:491-502.
94. Karring T. Regenerative periodontal therapy. J Int Acad Periodontol 2000;2:101-109.
95. Andreasen JO, Andreasen FM. Concussion and subluxation. In: Andreason JO, Andreason, FM, eds. Essentials of Traumatic Injuries to the Teeth. Copenhagen: Munskgaard, 1990: 77.