Adaptive vs. group sequential self-designing trials

Biometrical Journal

Volumn 48, Issue 4, 2006, Pages 710-712

  Mehrotra, Devan V ^a   Fan, Xiaoyin ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Adaptive planning; Early stopping; Group sequential clinical trials; Non inferiority; Repeated confidence intervals; Self designing; Switching to superiority

Indexed keywords

ADAPTIVE PLANNING; CLINICAL TRIAL; CONFIDENCE INTERVAL; EARLY STOPPING; GROUP SEQUENTIAL CLINICAL TRIAL; NON-INFERIORITY; REPEATED CONFIDENCE INTERVAL; SELF-DESIGNING; SEQUENTIAL CLINICAL TRIALS; SWITCHING TO SUPERIORITY;

STATISTICAL METHODS;

EID: 33748543260     PISSN: 03233847     EISSN: 15214036     Source Type: Journal    
DOI: 10.1002/bimj.200610259     Document Type: Review

References (3)

1. Jennison, C., and Turnbull, B. W. (1989). Interim analyses: the repeated confidence interval approach. Journal of the Royal Statistical Society, Series B 51, 305-361.
2. Lan, K. K. G., Reboussin, D. M., and DeMets, D. L. (1994). Information and information fractions for design and sequential monitoring of clinical trials. Communications in Statistics - Theory and Methods 23, 403-420.
3. Tsiatis, A. A. and Mehta, C. (2003). On the inefficiency of the adaptive design for monitoring clinical trials. Statistical methods for comparison to placebo in active-controlled trials. Biometrika 90, 367-378.