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Volumn 43, Issue 3, 2006, Pages 336-341

Pepsin, a reliable marker of gastric aspiration, is frequently detected in tracheal aspirates from premature ventilated neonates: Relationship with feeding and methylxanthine therapy

Author keywords

Gastric aspiration; Gastroesophageal reflux; Methylxanthine; Pepsin; Premature infants

Indexed keywords

AMINOPHYLLINE; CAFFEINE CITRATE; METHYLXANTHINE; PEPSIN A;

EID: 33748532492     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpg.0000232015.56155.03     Document Type: Article
Times cited : (66)

References (43)
  • 1
  • 3
    • 0036142427 scopus 로고    scopus 로고
    • Gastroesophageal reflux and apnea of prematurity: No temporal relationship
    • Peter CS, Sprodowski N, Bohnhorst B, et al. Gastroesophageal reflux and apnea of prematurity: no temporal relationship. Pediatrics 2002;109:8-11.
    • (2002) Pediatrics , vol.109 , pp. 8-11
    • Peter, C.S.1    Sprodowski, N.2    Bohnhorst, B.3
  • 4
    • 0031743726 scopus 로고    scopus 로고
    • Mechanisms of gastroesophageal reflux in healthy premature infants
    • Omari TI, Barnett CP, Snel A, et al. Mechanisms of gastroesophageal reflux in healthy premature infants. J Pediatr 1998;133:650-4.
    • (1998) J Pediatr , vol.133 , pp. 650-654
    • Omari, T.I.1    Barnett, C.P.2    Snel, A.3
  • 5
    • 3342979843 scopus 로고    scopus 로고
    • Paradoxical impact of body positioning on gastroesophageal reflux and gastric emptying in the premature neonate
    • Omari TI, Rommel N, Staunton E, et al. Paradoxical impact of body positioning on gastroesophageal reflux and gastric emptying in the premature neonate. J Pediatr 2004;145:194-200.
    • (2004) J Pediatr , vol.145 , pp. 194-200
    • Omari, T.I.1    Rommel, N.2    Staunton, E.3
  • 6
    • 0036786818 scopus 로고    scopus 로고
    • Mechanisms of gastrooesophageal reflux in preterm and term infants with reflux disease
    • Omari TI, Barnett CP, Benninga MA, et al. Mechanisms of gastrooesophageal reflux in preterm and term infants with reflux disease. Gut 2002;51:475-9.
    • (2002) Gut , vol.51 , pp. 475-479
    • Omari, T.I.1    Barnett, C.P.2    Benninga, M.A.3
  • 7
    • 0021038730 scopus 로고
    • Gastric emptying time in premature and compromised infants
    • Siegel M. Gastric emptying time in premature and compromised infants. J Pediatr Gastroenterol Nutr 1983;2:S136-40.
    • (1983) J Pediatr Gastroenterol Nutr , vol.2
    • Siegel, M.1
  • 8
    • 0032698830 scopus 로고    scopus 로고
    • Prevalence of gastroesophageal reflux in infants with recurrent brief apneic episodes
    • Sheikh S, Stephen TC, Sisson B. Prevalence of gastroesophageal reflux in infants with recurrent brief apneic episodes. Can Respir J 1999;6:401-4.
    • (1999) Can Respir J , vol.6 , pp. 401-404
    • Sheikh, S.1    Stephen, T.C.2    Sisson, B.3
  • 9
    • 0025288902 scopus 로고    scopus 로고
    • The relationship of respiratory complications from gastroesophageal reflux to prematurity in infants
    • Jolley SG, Halpern CT, Sterling CE, et al. The relationship of respiratory complications from gastroesophageal reflux to prematurity in infants. J Pediatr Surg 1999;25:755-7.
    • (1999) J Pediatr Surg , vol.25 , pp. 755-757
    • Jolley, S.G.1    Halpern, C.T.2    Sterling, C.E.3
  • 10
    • 0018714355 scopus 로고
    • Gastroesophageal reflux causing respiratory distress and apnea in newborn infants
    • Herbst JJ, Minton SD, Book LS. Gastroesophageal reflux causing respiratory distress and apnea in newborn infants. J Pediatr 1979;95:763-8.
    • (1979) J Pediatr , vol.95 , pp. 763-768
    • Herbst, J.J.1    Minton, S.D.2    Book, L.S.3
  • 11
    • 0017118127 scopus 로고
    • Aspiration pneumoni: Incidence of aspiration with endotracheal tubes
    • Spray SB, Zuidema GD, Cameron JL. Aspiration pneumoni: incidence of aspiration with endotracheal tubes. Am J Surg 1976;131:701-3.
    • (1976) Am J Surg , vol.131 , pp. 701-703
    • Spray, S.B.1    Zuidema, G.D.2    Cameron, J.L.3
  • 12
    • 0032996739 scopus 로고    scopus 로고
    • Prevention of tracheal aspiration using the pressure-limited tracheal tube cuff
    • Young PJ, Basson C, Hamilton D, et al. Prevention of tracheal aspiration using the pressure-limited tracheal tube cuff. Anaesthesia 1999;54:559-63.
    • (1999) Anaesthesia , vol.54 , pp. 559-563
    • Young, P.J.1    Basson, C.2    Hamilton, D.3
  • 13
    • 0024114089 scopus 로고
    • Pathophysiology of gastroesophageal reflux and distal esophageal motility in children with gastroesophageal reflux disease
    • Cucchiara S, Staiano A, Di Lorenzo C, et al. Pathophysiology of gastroesophageal reflux and distal esophageal motility in children with gastroesophageal reflux disease. J Pediatr Gastroenterol Nutr 1988;7:830-6.
    • (1988) J Pediatr Gastroenterol Nutr , vol.7 , pp. 830-836
    • Cucchiara, S.1    Staiano, A.2    Di Lorenzo, C.3
  • 14
    • 4444269293 scopus 로고    scopus 로고
    • Progressive, severe lung injury secondary to the interaction of insults in gastric aspiration
    • Knight PR, Davidson BA, Nader ND, et al. Progressive, severe lung injury secondary to the interaction of insults in gastric aspiration. Exp Lung Res 2004;30:535-57.
    • (2004) Exp Lung Res , vol.30 , pp. 535-557
    • Knight, P.R.1    Davidson, B.A.2    Nader, N.D.3
  • 15
    • 0027203529 scopus 로고
    • The pathophysiologic changes following bile aspiration in a porcine lung model
    • Porembka DT, Kier A, Sehlhorst S, et al. The pathophysiologic changes following bile aspiration in a porcine lung model. Chest 1993;104:919-24.
    • (1993) Chest , vol.104 , pp. 919-924
    • Porembka, D.T.1    Kier, A.2    Sehlhorst, S.3
  • 16
    • 0028873866 scopus 로고
    • Aspiration complicating bronchopulmonary dysplasia
    • Radford PJ, Stillwell PC, Blue B, et al. Aspiration complicating bronchopulmonary dysplasia. Chest 1995;107:185-8.
    • (1995) Chest , vol.107 , pp. 185-188
    • Radford, P.J.1    Stillwell, P.C.2    Blue, B.3
  • 17
    • 0034204359 scopus 로고    scopus 로고
    • Gastroesophageal reflux in very low birth weight infants: Association with chronic lung disease and outcomes through 1 year of age
    • Fuloria M, Hiatt D, Dillard RG, et al. Gastroesophageal reflux in very low birth weight infants: association with chronic lung disease and outcomes through 1 year of age. J Perinatol 2000;20:235-9.
    • (2000) J Perinatol , vol.20 , pp. 235-239
    • Fuloria, M.1    Hiatt, D.2    Dillard, R.G.3
  • 18
    • 0035078602 scopus 로고    scopus 로고
    • Simultaneous monitoring of gastric and oesophageal pH reveals limitations of conventional oesophageal pH monitoring in milk-fed infants
    • Mitchell DJ, McClure BG, Tubman TR. Simultaneous monitoring of gastric and oesophageal pH reveals limitations of conventional oesophageal pH monitoring in milk-fed infants. Arch Dis Child 2001;84:273-6.
    • (2001) Arch Dis Child , vol.84 , pp. 273-276
    • Mitchell, D.J.1    McClure, B.G.2    Tubman, T.R.3
  • 19
    • 0035512143 scopus 로고    scopus 로고
    • Can pH monitoring reliably detect gastroesophageal reflux in preterm infants?
    • Grant L, Cochran D. Can pH monitoring reliably detect gastroesophageal reflux in preterm infants? Arch Dis Child Fetal Neonatal Ed 2001;85:F155-7.
    • (2001) Arch Dis Child Fetal Neonatal Ed , vol.85
    • Grant, L.1    Cochran, D.2
  • 20
    • 0020686573 scopus 로고
    • Detection of gastric contents in tracheal fluid of infants by lactose assay
    • Hopper AO, Kwong LK, Stevenson DK, et al. Detection of gastric contents in tracheal fluid of infants by lactose assay. J Pediatr 1983;102:415-8.
    • (1983) J Pediatr , vol.102 , pp. 415-418
    • Hopper, A.O.1    Kwong, L.K.2    Stevenson, D.K.3
  • 21
    • 0032793601 scopus 로고    scopus 로고
    • Lipid-laden macrophages in the tracheal aspirate of ventilated neonates receiving Intralipid: A pilot study
    • Kajetanowicz A, Stinson D, Laybolt KS, et al. Lipid-laden macrophages in the tracheal aspirate of ventilated neonates receiving Intralipid: a pilot study. Pediatr Pulmonol 1999;28:101-8.
    • (1999) Pediatr Pulmonol , vol.28 , pp. 101-108
    • Kajetanowicz, A.1    Stinson, D.2    Laybolt, K.S.3
  • 22
    • 26944443873 scopus 로고    scopus 로고
    • Pepsin-like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts
    • Ward C, Forrest IA, Brownlee IA, et al. Pepsin-like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts. Thorax 2005;60:872-4.
    • (2005) Thorax , vol.60 , pp. 872-874
    • Ward, C.1    Forrest, I.A.2    Brownlee, I.A.3
  • 23
    • 12444317211 scopus 로고    scopus 로고
    • A new pepsin assay to detect pulmonary aspiration of gastric contents among newly intubated patients
    • Ufberg JW, Bushra JS, Patel D, et al. A new pepsin assay to detect pulmonary aspiration of gastric contents among newly intubated patients. Am J Emerg Med 2004;22:612-4.
    • (2004) Am J Emerg Med , vol.22 , pp. 612-614
    • Ufberg, J.W.1    Bushra, J.S.2    Patel, D.3
  • 24
    • 34547147605 scopus 로고    scopus 로고
    • Detection of pepsin and glucose in tracheal secretions as indicators of aspiration in mechanically ventilated children
    • Meert KL, Daphtary KM, Metheny NA. Detection of pepsin and glucose in tracheal secretions as indicators of aspiration in mechanically ventilated children. Pediatr Crit Care Med 2002;3:19-22.
    • (2002) Pediatr Crit Care Med , vol.3 , pp. 19-22
    • Meert, K.L.1    Daphtary, K.M.2    Metheny, N.A.3
  • 26
    • 0022529721 scopus 로고
    • Influence of xanthines on gastroesophageal reflux in infants at risk for sudden infant death syndrome
    • Vandenplas Y, De Wolf D, Sacre L. Influence of xanthines on gastroesophageal reflux in infants at risk for sudden infant death syndrome. Pediatrics 1986;77:807-10.
    • (1986) Pediatrics , vol.77 , pp. 807-810
    • Vandenplas, Y.1    De Wolf, D.2    Sacre, L.3
  • 27
    • 0033800118 scopus 로고    scopus 로고
    • Effects of early inhaled beclomethasone therapy on tracheal aspirate inflammatory mediators IL-8 and IL-1ra in ventilated preterm infants at risk for bronchopulmonary dysplasia
    • Gupta GK, Cole CH, Abbasi S, et al. Effects of early inhaled beclomethasone therapy on tracheal aspirate inflammatory mediators IL-8 and IL-1ra in ventilated preterm infants at risk for bronchopulmonary dysplasia. Pediatr Pulmonol 2000;30:275-81.
    • (2000) Pediatr Pulmonol , vol.30 , pp. 275-281
    • Gupta, G.K.1    Cole, C.H.2    Abbasi, S.3
  • 28
    • 0030731406 scopus 로고    scopus 로고
    • Elevation of interleukin-8 and interleukin-6 precedes the influx of neutrophils in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia
    • Munshi UK, Niu JO, Siddiq MM, et al. Elevation of interleukin-8 and interleukin-6 precedes the influx of neutrophils in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia. Pediatr Pulmonol 1997;5:331-6.
    • (1997) Pediatr Pulmonol , vol.5 , pp. 331-336
    • Munshi, U.K.1    Niu, J.O.2    Siddiq, M.M.3
  • 29
    • 0030038943 scopus 로고    scopus 로고
    • Elevated cytokine levels in tracheobronchial aspirate fluids from ventilator treated neonates with BPD
    • Tullus K, Noack GW, Burman LG, et al. Elevated cytokine levels in tracheobronchial aspirate fluids from ventilator treated neonates with BPD. Eur J Pediatr 1996;155:112-6.
    • (1996) Eur J Pediatr , vol.155 , pp. 112-116
    • Tullus, K.1    Noack, G.W.2    Burman, L.G.3
  • 30
    • 0027182864 scopus 로고
    • Scintigraphy versus pH probe for quantification of pediatric gastroesophageal reflux: A study using concurrent multiplexed data and acid feedings
    • Orenstein SR, Klein HA, Rosenthal MS. Scintigraphy versus pH probe for quantification of pediatric gastroesophageal reflux: a study using concurrent multiplexed data and acid feedings. J Nucl Med 1993;34:1228-34.
    • (1993) J Nucl Med , vol.34 , pp. 1228-1234
    • Orenstein, S.R.1    Klein, H.A.2    Rosenthal, M.S.3
  • 31
    • 0036519032 scopus 로고    scopus 로고
    • Pepsin as a marker for pulmonary aspiration
    • Metheny NA, Chang YH, Ye JS, et al. Pepsin as a marker for pulmonary aspiration. Am J Crit Care 2002;11:150-4.
    • (2002) Am J Crit Care , vol.11 , pp. 150-154
    • Metheny, N.A.1    Chang, Y.H.2    Ye, J.S.3
  • 32
    • 33644636494 scopus 로고    scopus 로고
    • Acid and non-acid gastroesophageal reflux in newborns. Preliminary results using intraluminal impedance
    • Lopez Alonzo M, Moya MJ, Cabo JA, et al. Acid and non-acid gastroesophageal reflux in newborns. Preliminary results using intraluminal impedance. Cir Pediatr 2005;18:121-6.
    • (2005) Cir Pediatr , vol.18 , pp. 121-126
    • Lopez Alonzo, M.1    Moya, M.J.2    Cabo, J.A.3
  • 33
    • 0022502604 scopus 로고
    • Radionuclide study of bronchial aspiration in intensive care newborn children
    • Valat C, Demont F, Pegat MA, et al. Radionuclide study of bronchial aspiration in intensive care newborn children. Nucl Med Commun 1986;7:593-8.
    • (1986) Nucl Med Commun , vol.7 , pp. 593-598
    • Valat, C.1    Demont, F.2    Pegat, M.A.3
  • 34
    • 0003387422 scopus 로고
    • Development of pepsinogens
    • Lebenthal E ed. New York: Raven Press
    • Defize J. Development of pepsinogens. In: Lebenthal E ed. Human Gastrointestinal Development. New York: Raven Press, 1989:299-324.
    • (1989) Human Gastrointestinal Development , pp. 299-324
    • Defize, J.1
  • 35
    • 0016051818 scopus 로고
    • Radioimmunoassay of group I pepsinogens in serum
    • Samloff IM, Liebman WM. Radioimmunoassay of group I pepsinogens in serum. Gastroenterology 1974;66:494-502.
    • (1974) Gastroenterology , vol.66 , pp. 494-502
    • Samloff, I.M.1    Liebman, W.M.2
  • 37
    • 0032706843 scopus 로고    scopus 로고
    • The new BPD: An arrest of lung development
    • Jobe A. The new BPD: an arrest of lung development. Pediatr Res 1999;46:641-3.
    • (1999) Pediatr Res , vol.46 , pp. 641-643
    • Jobe, A.1
  • 38
    • 1642279555 scopus 로고    scopus 로고
    • Detection of pepsin in tracheal secretions after forced small-volume aspirations of gastric juice
    • Metheny NA, Dahms TE, Chang YH, et al. Detection of pepsin in tracheal secretions after forced small-volume aspirations of gastric juice. JPEN J Parenter Enteral Nutr 2004;28:79-84.
    • (2004) JPEN J Parenter Enteral Nutr , vol.28 , pp. 79-84
    • Metheny, N.A.1    Dahms, T.E.2    Chang, Y.H.3
  • 39
    • 0015430496 scopus 로고
    • Caffeine and the lower esophageal sphincter
    • Dennish GW, Castell DO. Caffeine and the lower esophageal sphincter. Am J Dig Dis 1972;17:993-6.
    • (1972) Am J Dig Dis , vol.17 , pp. 993-996
    • Dennish, G.W.1    Castell, D.O.2
  • 40
    • 0016803341 scopus 로고
    • Gastric acid secretion and loweresophageal-sphincter pressure in response to coffee and caffeine
    • Cohen S, Booth GH Jr. Gastric acid secretion and loweresophageal- sphincter pressure in response to coffee and caffeine. N Engl J Med 1975;293:897-9.
    • (1975) N Engl J Med , vol.293 , pp. 897-899
    • Cohen, S.1    Booth Jr., G.H.2
  • 41
    • 0033985571 scopus 로고    scopus 로고
    • Bronchoalveolar lavage in children. ERS Task Force on bronchoalveolar lavage in children
    • European Respiratory Society.
    • de Blic J, Midulla F, Barbato A, et al. Bronchoalveolar lavage in children. ERS Task Force on bronchoalveolar lavage in children. European Respiratory Society. Eur Respir J 2000;15:217-31.
    • (2000) Eur Respir J , vol.15 , pp. 217-231
    • De Blic, J.1    Midulla, F.2    Barbato, A.3
  • 42
    • 0026722638 scopus 로고
    • Gastric secretion in infants. Application to the study of sudden infant death syndrome and apparently life-threatening events
    • Mouterde O, Dacher JN, Basuyau JP, et al. Gastric secretion in infants. Application to the study of sudden infant death syndrome and apparently life-threatening events. Biol Neonate 1992;62:15-22.
    • (1992) Biol Neonate , vol.62 , pp. 15-22
    • Mouterde, O.1    Dacher, J.N.2    Basuyau, J.P.3
  • 43
    • 0033847916 scopus 로고    scopus 로고
    • Indicators of postpyloric feeding tube placement in children
    • Gharpure V, Meert KL, Sarnaik AP, et al. Indicators of postpyloric feeding tube placement in children. Crit Care Med 2000;28:2962-6.
    • (2000) Crit Care Med , vol.28 , pp. 2962-2966
    • Gharpure, V.1    Meert, K.L.2    Sarnaik, A.P.3


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