HER2-positive breast cancer brain metastases: Multiple responses to systemic chemotherapy and trastuzumab - A case report

Journal of Neuro-Oncology

Volumn 79, Issue 3, 2006, Pages 289-292

  Church, D N ^a   Bahl, A ^a   Jones, A ^b   Price, Chris G A ^a  

^a BRISTOL HAEMATOLOGY AND ONCOLOGY CENTRE   (United Kingdom)

^b BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

Brain metastases; Breast cancer; C erbB2; Chemotherapy; HER2; Herceptin ; Trastuzumab

Indexed keywords

CAPECITABINE; CARBOPLATIN; CYCLOPHOSPHAMIDE; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; FLUOROURACIL; METHOTREXATE; NAVELBINE; PACLITAXEL; TAMOXIFEN; TRASTUZUMAB;

ADULT; ARTICLE; BRAIN METASTASIS; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER GRADING; CANCER RADIOTHERAPY; CANCER SURVIVAL; CASE REPORT; DOSE RESPONSE; HUMAN; MALE; MASTECTOMY; NUCLEAR MAGNETIC RESONANCE IMAGING;

ADULT; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN NEOPLASMS; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN;

EID: 33748528129     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-006-9139-8     Document Type: Article

References (10)

1. Slamon DJ, Clark GM, Wong SG, et al. (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235:177-182
2. Slamon DJ, Leyland-Jones B, Shak S, et al. (2001) Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344:783-792
3. Bendell JC, Domchek SM, Burstein HJ, et al. (2003) Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer 97:2972-2977
4. Clayton AJ, Danson S, Jolly S, et al. (2004) Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer. Br J Cancer 91:639-643
5. Kirsch DG, Ledezma CJ, Mathews CS, et al. (2005) Survival after brain metastases from breast cancer in the trastuzumab era. J Clin Oncol 23:2114-2116; author reply 2116-2117
6. Pestalozzi BC, Brignoli S (2000) Trastuzumab in CSF. J Clin Oncol 18:2349-2351
7. Stewart DJ, Mikhael NZ, Nair RC, et al. (1988) Platinum concentrations in human autopsy tumor samples. Am J Clin Oncol 11:152-158
8. Rosner D, Nemoto T, Lane WW (1986) Chemotherapy induces regression of brain metastases in breast carcinoma. Cancer 58:832-839
9. Weinstein JD, Toy FJ, Jaffe ME, Goldberg HI (1973) The effect of dexamethasone on brain edema in patients with metastatic brain tumors. Neurology 23:121-129
10. Pegram MD, Konecny GE, O'Callaghan C, et al. (2004) Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer. J Natl Cancer Inst 96:739-749